Bücher von Bapu Thorat

As per the New Education Policy (NEP ¿ 2020), Syllabus of the First-year Chemistry of Dr. BAMU, Chh. Sambhajinagar get changed from 2022-23. It includes four papers (two in each semester) ¿ Inorganic, Organic, Physical and Applied Chemistry covering different topics of Basic and Applied Chemistry. This book covers all syllabus of B.Sc. I of Dr. BAMU with assignments. The Inorganic section covers various topics including basic theories of atomic structure and quantum numbers, chemical and molecular bondings & structures on the basis of ionic bonding, covalent bonding, hybridization, VSEPR theory, MOT. Organic chemistry papers cover topics including - the fundamentals of organic reaction mechanism; isomerization & stereochemistry; properties, synthesis and reactions of benzenes, alkyl & aryl halides, alcohols & phenols. Chemical Energetics ¿ Thermodynamics and thermochemistry, chemical equilibrium, gaseous state and chemical kinetics are included in the physical chemistry paper. Some new and applied chemistry topics such as Basic principles of Chromatography ¿ Paper and TLC, properties and synthesis of some essential drugs, properties and types of different glass, etc.

Heteroatoms constitute a very common fragment of a number of active pharmaceutical ingredients as well as excipients; from the point of view of significance, it is all the same if these are isosterically/bioisosterically replaced carbons/carbon substructures in aliphatic structures or real heterocycles. Many heterocyclic scaffolds can be considered as privilege structures including aromatic skeletons. Most frequently, nitrogen heterocycles or various positional combinations of nitrogen atoms, sulphur, and oxygen in five- or six-membered rings/fused rings can be found. There are a number of novel pathways found for their synthesis including homogenous or heterogenous catalytic system. According to statistics, more than 85% of all biologically-active chemical entities contain a heterocycle. This fact reflects the central role of heterocycles in modern drug design therefore their synthesis is important.

In this book series of General Chemistry, my aim is to provide a handy books that addresses the requirements of chemistry courses of students at university level and bring together those areas of chemistry that traditionally have been taught apart from one another. In this part, I have been covered the basic topics of electrochemistry, phase diagrams, transition metals, coordination chemistry and chemistry of carboxylic and sulphonic acids with examples that support to understand the concepts. I have been always grateful to Google and Authers & Publishers who provides online books and other exciting writing materials.

Multicomponent synthesis has attracted great attention due to its selectivity, synthetic convergency and atom economy in the area of drug discovery, material science and synthetic chemistry. The most common MCRs are - Mannich Reaction, Hantzsch Reaction, Biginelli Reaction, Ugi Reaction, Strecker Reaction, Passerini Reaction, Prins Reaction, Gewald Reaction. The pyrimidine derivatives such as cytosine, uracil and thymine are present in DNA and RNA which was synthesised by Biginelli Reaction. A multicomponent reaction of an aldehyde, ¿-keto ester, and urea in the presence of Bronsted acid, Lewis acid or Lewisbase catalysts forming dihydropyrimidine. In Biginelli chemistry Lewis acids halides, triflates and other salts of Li, Bi, Fe, Cu, Zn, Ru, Rh, W, Mo, Mg, Co, Ni, Sb, Yb, La, Zr, Ce, Sm, Sc, V, Cd, Al, Ag, Nd, Ca, I, B, Sr, Si, Nd, Nb, K, Na, Ga, Pb, Sn etc. (sometimes even repeatedly in different journals) have been employed to achieve excellent yields and reduce reaction time. Zinc chloride was an important Lewis acid catalyst while calcium chloride is used as Lewis acid or Lewis base catalyst depending on the role ion as catalyst.

The world is facing the problem of tuberculosis. In accounts for approximately one third of the global incidence of TB (Goble Tuberculosis Report, 2018, World Health Organization). Each year, 1.8 million new cases (the global incidence is 6.4 million), which lead to 1.3 million deaths (range, 1.2¿1.4 million) among HIV-negative people, and there were an additional 300 000 deaths from TB (range, 266 000¿335 000) among HIV-positive people, although the prevalence of HIV among new cases in India is just 3-4 percent compared with global average of 9 percent. Although the existing method of curing is very effective against TB, the length of treatment, the toxicity and the potential for drug-drug interactions are factors that highlight the need for new anti-TB drugs. New drugs are urgently needed because TB remains a global health priority, as around nine million new cases are estimated each year with almost two million fatalities. The libraries of different substituted synthetic and natural molecules were scanned against this cell wall proteins, DNA, enzymes by using different computational programs, studying their SAR properties and other molecular structural based properties.