Bücher von Cheorl-Ho Kim

This book describes general glycobiology in emphasizing the structures, biosynthesis, glycosylation and distribution of the glycans and xenogenic glycoantigens in eukaryotic cells of mammals including mouse, swine, chimpanzee and human. In the middle, I have focused on topics in xenotransplantation glycobiology and expand descriptions of allogenic and xenoantigenic transplantation to open the dawn in insights into the origin of life. One of the biological diversity, named species diversity, is a phenomenon environmentally adapted from the evolutionary process for long period. The distinct structures of glycans discriminate each organism and are the essential molecular basis of the discrimination and difference between the organisms, giving an incompatibility between the different species. Diversity and variations in carbohydrate chain structures between family, species, kingdoms and domains mark the global pattern and signs of immune self- and non-self recognition. In human, diversity in ABH blood group antigens is observed in human family and this type pattern distinguishes individuals from a pan-family to non-dividable unit of the family. Blood transfusion and organ transplantation are impossible even in the allogenic cross between humans if carbohydrates are ignored. This explains how and how human beings are a lonely existence. ABH-related antibodies induce hemolysis or hyperacute or allograft rejection due to incompatible graft property even between the same species. The incompatibility is an immunologic rejection when the recipient host receives the tissues or organs from the different species of donors, as well-known in pig-to-human xenotransplantation. The immunologic incompatibility between the donor pigs and the recipient human are based on the evolutionary distance between pigs and humans. This distance allows a xenograft rejection between the 2 mammals. Modification or deletion of the specific gene locus for immune rejection on genome of donor animalsdisrupts the immunological recognition ligands of the donor organs, consequently preventing the immune rejection of the human recipient and xenograft rejection. This book helps undergraduate and graduate students, researcher and professors who are involved in the glycobiology and xenoantigenic biology with recent advances in the xenotransplantation basic and clinic.

This book presents the latest knowledge and the most recent research results on glycobiology of innate immunology. Innate immunity is the crucial part of the immunological defense system that exerts their distinct functions through binding to certain functional glycoproteins. They play a role in various human diseases and also function against microbial invaders and self-associated molecular patterns. Co-regulated expression of glycan-binding is associated with many biological components such as cellular oncotransformation, phenotype change, neuronal or embryonic development, regulation of cell division, cell-cell interaction, cell attachment, adhesion, and motility, and intracellular signaling via protein-carbohydrate or carbohydrate-carbohydrate interactions.This book opens by providing the key background on glycans in innate immunity and its mechanisms behind the Dendritic cell interactions during infection and inflammation are examined in depth, and the concluding chapter is devoted to signaling tumor immunotherapy. Up-to-date information is then presented on all aspects of glycan structure-recognizing signaling. The book should assist in the further development of new strategies against emerging infectious agents and intractable diseases.

This book presents the latest knowledge and the most recent research results on glycobiology of innate immunology. Innate immunity is the crucial part of the immunological defense system that exerts their distinct functions through binding to certain functional glycoproteins. They play a role in various human diseases and also function against microbial invaders and self-associated molecular patterns. Co-regulated expression of glycan-binding is associated with many biological components such as cellular oncotransformation, phenotype change, neuronal or embryonic development, regulation of cell division, cell¿cell interaction, cell attachment, adhesion, and motility, and intracellular signaling via protein¿carbohydrate or carbohydrate¿carbohydrate interactions.This book opens by providing the key background on glycans in innate immunity and its mechanisms behind the Dendritic cell interactions during infection and inflammation are examined in depth, and the concluding chapteris devoted to signaling tumor immunotherapy. Up-to-date information is then presented on all aspects of glycan structure-recognizing signaling. The book should assist in the further development of new strategies against emerging infectious agents and intractable diseases.

The latest advances from leading experts in this vital field of medical endeavor comprise the core value of this book, which focuses on the molecular biology of carbohydrate antigens, including sialic acids, which function as xenoantigenic determinants in humans.