Bücher von Daniel Sorensen

This book provides an introduction to computer-based methods for the analysis of genomic data. Breakthroughs in molecular and computational biology have contributed to the emergence of vast data sets, where millions of genetic markers for each individual are coupled with medical records, generating an unparalleled resource for linking human genetic variation to human biology and disease. Similar developments have taken place in animal and plant breeding, where genetic marker information is combined with production traits. An important task for the statistical geneticist is to adapt, construct and implement models that can extract information from these large-scale data. An initial step is to understand the methodology that underlies the probability models and to learn the modern computer-intensive methods required for fitting these models. The objective of this book, suitable for readers who wish to develop analytic skills to perform genomic research, is to provide guidance to take this first step.This book is addressed to numerate biologists who typically lack the formal mathematical background of the professional statistician. For this reason, considerably more detail in explanations and derivations is offered. It is written in a concise style and examples are used profusely. A large proportion of the examples involve programming with the open-source package R. The R code needed to solve the exercises is provided. The MarkDown interface allows the students to implement the code on their own computer, contributing to a better understanding of the underlying theory.Part I presents methods of inference based on likelihood and Bayesian methods, including computational techniques for fitting likelihood and Bayesian models. Part II discusses prediction for continuous and binary data using both frequentist and Bayesian approaches. Some of the models used for prediction are also used for gene discovery. The challenge is to find promising genes without incurring a large proportion of false positive results. Therefore, Part II includes a detour on False Discovery Rate assuming frequentist and Bayesian perspectives. The last chapter of Part II provides an overview of a selected number of non-parametric methods. Part III consists of exercises and their solutions.Daniel Sorensen holds PhD and DSc degrees from the University of Edinburgh and is an elected Fellow of the American Statistical Association. He was professor of Statistical Genetics at Aarhus University where, at present, he is professor emeritus.

global automotive industry currently undergoing substantial changes the way firms compete. Driving forces behind these changes globalized markets, technologies, more demanding customers. structures are evolving within the automotive companies, there increased evidence of the importance of we- functioning networks order to gain a competitive advantage. The benchmarks for the automotive companies the demands for higher product quality, more efficiency bringing products to markets, a reduction of time to market. above changes present the starting point for the research by Daniel which deals with the product development process, particular within the automobile industry. It a subject, which to now hasn't been satisfactorily treated. Daniel sets out to explain value the engineering product development paradigms of point- set-based concurrent engineering from a holistic viewpoint. First of all, identifies select capabilities based empirical studies of best practice current automotive product development, particular at Toyota Motor Corporation. This a pronounced understanding of why different product engineering systems able to yield a competitive advantage the market. Second of all, applies a real option valuation model to these capabilities within a financial economics framework order to quantify from the viewpoint of shareholders the value of poi- concurrent engineering respectively. In this way, automotive firms are given a powerful tool, which enables them to identify the optimal amount of innovation to build into the product development process. Finally, Daniel establishes five clear principles of product development, which give significant direction for automotive executives designing controlling the product development process optimally uncertain dynamic environment.

This book provides the foundations of likelihood, Bayesian and MCMC methods in the context of genetic analysis of quantitative traits. Effort has been made to relate biological to statistical parameters throughout, and extensive examples are included to illustrate the arguments.