Bücher von Ehab Mohamed

Diabetes mellitus is a complex of metabolic disease characterized by hyperglycemia , diminished insulin production, impaired insulin action , or a combination of both resulting in the inability of glucose to be transported from the blood stream into the tissues, which in turn results in high blood glucose levels and excretion of glucose in the urine, The cell functions involved in the action of insulin receptor binding enzyme and transporter activities are controlled by membrane properties . Fatty acids composition of membrane phospholipids are affected by the composition of the dietary fat .Changes in the fatty acids composition of erythrocyte membrane , which are easily accessible cells, reflects changes in that of membrane phospholipids of less accessible tissues . The fatty acids composition of cell membrane can influence membrane associated phenomena such as the interaction between insulin and its receptors. Thus it is from interest to study the relationship between cell membrane phospholipids fractions and their role in insulin action, also to study the role of omega-3 fatty acids in reducing oxidative stress in diabetic rats.

The structure, function, and composition of the basement membrane of glomerular capillaries of the mammalian kidney have been extensively studied, in light of the membrane''s frequent involvement in renal diseases. A novel mathematical model, based on the Fiber Matrix Theory, was developed to describe the dynamics of permselectivity of the glomerular capillary barrier using mainly its hemodynamic and morphometric variables. The glomerular basement membrane was represented as a homogeneous 3D meshwork of fibers of uniform length (L¿), radius (R¿), and packing density (N¿v) and characterized by a local Darcy permeability. The model was appropriate for simulating in vivo fractional clearance data of neutral test macromolecules from an experimental rat model. We believe that the L¿ and R¿ best-fit numerical values, characterizing a glomerular basement membrane geometrical arrangement, may represent diagnostic measures for renal function in health and disease. That is, these parameters may signify new insights for the diagnosis of some human nephropathies and possibly may explain the beneficial effects and/or sites of action of some pharmacological modifiers.