Bücher von Sandeep

The Future of Medicine: Identifying and Validating Therapeutic Targets in Drug DevelopmentDrug development is a complex and multi-faceted process that can take decades and billions of dollars to invest. At the heart of this process is the identification and validation of therapeutic targets, that is, biological molecules such as proteins, nucleic acids, or metabolites that play a critical role in the disease process and have the potential for therapeutic intervention.Target DiscoveryTherapeutic targets can be discovered in a number of ways, including:· Disease biology research: Researchers conduct basic and clinical research to understand the causes and effects of disease. This research can identify pathways that play a critical role in disease progression and can serve as targets for therapeutic intervention.· Genomics and proteomics: Through large-scale analysis of genetic and protein data, researchers can identify new targets. For example, genes or proteins associated with disease can be identified and evaluated as potential therapeutic targets.Target ValidationOnce a potential therapeutic target has been identified, it must be validated to ensure that it is a viable target for intervention. This validation process typically involves a number of steps, including:· In vitro studies: In vitro studies are conducted to assess the effect of a drug or other therapeutic agent on the target in a controlled laboratory setting.· In vivo studies: In vivo studies are conducted to assess the effect of a drug or other therapeutic agent on the target in a living organism.

This book presents a comprehensive analysis of diverse aspects of geohazards. The growing vulnerability and exposure to failures in risk reduction and policy-making increases the severity of geohazard impacts by many folds. Therefore, detailed geohazard analysis, modelling and forecasting are needed to reduce the impacts of extreme events.An interdisciplinary approach to hazard mitigation provides an advanced tool for risk reduction. The book thus summarizes recent modelling and analysis techniques for hazard assessment and risk mitigation. Topics discussed in the book are hazard and risk associated with earthquakes, vulnerability assessment for landslides and avalanches, the assessment of tsunami risk in coastal regions, the implementation of early warning systems to prevent catastrophic consequences, climate change risk modelling and risk communication. The convergent approach with the aspects of natural, engineering, and social sciences attracts a vast audienceworking to advance disaster science. This book also significantly facilitates the acquisition of policy-relevant knowledge for risk reduction, which is beneficial to the general public.

HOMOEOPATHIC ARROWS-4To make homoeopathic prescription more sure & confident.To reach the core & soul of the remedy & sick.