Bücher von Savita Dhongade-Desai

L'irradiazione a microonde ha guadagnato popolarità nell'ultimo decennio come potente strumento per la sintesi rapida ed efficiente di una varietà di composti con una maggiore velocità di reazione e un migliore campo di prodotti nella sintesi chimica e nella formazione di una varietà di legami carbonio-eteroatomo. La frazione chinazolina è un elemento costitutivo di circa 150 alcaloidi e farmaci presenti in natura. I sistemi di anelli chinazolinici hanno un ruolo di primo piano nella chimica medicinale e possiedono attività biologiche quali antimalariche, anticonvulsivanti, antibatteriche, antidiabetiche e antitumorali. Il lavoro è una continuazione della serie di sette libri: Pirimidine, Quinazoline, Pirimidine fuse con anelli eterociclici, Novel Pyrazoles part I e Novel Pyrazoles part II, Triazolo Pyrimidines e Thiazolo Pyrimidines. Il libro intitolato "Triazolo Quinazolines: Synthesis and Biological Prediction Study" comprende una rassegna completa delle reazioni MW e la sintesi, la caratterizzazione e lo studio di previsione biologica dei derivati triazolo-quinazolinici. I contenuti del libro sono molto importanti per i ricercatori di chimica organica sintetica, eterociclica, farmaceutica e medicinale.

Die Mikrowellenbestrahlung hat in den letzten zehn Jahren an Popularität gewonnen, da sie ein leistungsfähiges Werkzeug für die schnelle und effiziente Synthese einer Vielzahl von Verbindungen mit erhöhter Reaktionsgeschwindigkeit und verbessertem Produktfeld bei der chemischen Synthese und der Bildung einer Vielzahl von Kohlenstoff-Heteroatom-Bindungen darstellt. Der Chinazolinrest ist ein Baustein für etwa 150 natürlich vorkommende Alkaloide und Arzneimittel. Chinazolin-Ringsysteme spielen in der medizinischen Chemie eine herausragende Rolle und besitzen biologische Wirkungen wie Malariamittel, Antikonvulsiva, antibakterielle Mittel, Antidiabetika und Krebsmedikamente. Die Arbeit ist eine Fortsetzung unserer Arbeit aus der Serie von sieben Büchern, nämlich Pyrimidine, Quinazoline, Pyrimidine fusioniert mit heterozyklischen Ringen, Novel Pyrazoles part I und Novel Pyrazoles part II, Triazolo Pyrimidine und Thiazolo Pyrimidine. Das Buch mit dem Titel "Triazolo Quinazolines: Synthesis and Biological Prediction Study" enthält eine umfassende Übersicht über MW-Reaktionen und die Synthese, Charakterisierung und biologische Vorhersage von Triazolo-Chinazolin-Derivaten. Der Inhalt der Bücher ist für die Forscher der synthetischen organischen, heterozyklischen, pharmazeutischen und medizinischen Chemie von großer Bedeutung.

L'irradiation par micro-ondes a gagné en popularité au cours de la dernière décennie en tant qu'outil puissant pour la synthèse rapide et efficace d'une variété de composés avec une vitesse de réaction accrue et un champ de produits amélioré dans la synthèse chimique et la formation d'une variété de liaisons carbone-hétéroatomes. La fraction quinazoline est un élément constitutif d'environ 150 alcaloïdes et médicaments naturels. Les systèmes d'anneaux quinazolines ont une caractéristique importante en chimie médicinale et possèdent des activités biologiques telles que l'antipaludisme, l'anticonvulsivant, l'antibactérien, l'antidiabétique et l'anticancéreux. Ce travail s'inscrit dans la continuité de la série de sept livres, à savoir Pyrimidines, Quinazolines, Pyrimidines fusionnées avec des anneaux hétérocycliques, Novel Pyrazoles part I et Novel Pyrazoles part II, Triazolo Pyrimidines et Thiazolo Pyrimidines. Le livre intitulé "Triazolo Quinazolines : Synthesis and Biological Prediction Study" comprend un examen complet des réactions MW et de la synthèse, de la caractérisation et de l'étude de la prédiction biologique des dérivés de la triazolo quinazoline. Le contenu de ces ouvrages est très important pour les chercheurs en chimie organique synthétique, hétérocyclique, pharmaceutique et médicinale.

La irradiación con microondas ha ganado popularidad en la última década como una poderosa herramienta para la síntesis rápida y eficiente de una variedad de compuestos con una velocidad de reacción mejorada y un mejor campo de productos en síntesis química y formación de una variedad de enlaces carbono-heteroátomo. La fracción de quinazolina es el componente básico de unos 150 alcaloides y fármacos naturales. Los sistemas de anillos de quinazolina ocupan un lugar destacado en la química medicinal y poseen actividades biológicas como antimaláricos, anticonvulsivos, antibacterianos, antidiabéticos y anticancerígenos. Este trabajo es la continuación de nuestra serie de siete libros: Pirimidinas, Quinazolinas, Pirimidinas fusionadas con anillos heterocíclicos, Nuevos pirazoles parte I y Nuevos pirazoles parte II, Triazolo pirimidinas y Tiazolo pirimidinas. El libro titulado "Triazolo Quinazolines: Synthesis and Biological Prediction Study" incluye una revisión exhaustiva de las reacciones de MW y el estudio de síntesis, caracterización y predicción biológica de los derivados de triazolo quinazolina. El contenido de los libros es de gran importancia para los investigadores de química sintética orgánica, heterocíclica, farmacéutica y medicinal.

A irradiação por micro-ondas ganhou popularidade na última década como uma ferramenta poderosa para a síntese rápida e eficiente de uma variedade de compostos com maior velocidade de reação e melhor campo de produtos na síntese química e formação de uma variedade de ligações carbono-heteroátomo. A porção quinazolina é um bloco de construção para cerca de 150 alcalóides e fármacos naturais. Os sistemas de anéis de quinazolina têm uma caraterística proeminente na química medicinal e possuem actividades biológicas tais como antimalárica, anticonvulsiva, antibacteriana, antidiabética e anticancerígena. A obra é uma continuação do nosso trabalho da série de sete livros, nomeadamente Pirimidinas, Quinazolinas, Pirimidinas fundidas com anéis heterocíclicos, Novos Pirazóis parte I e Novos Pirazóis parte II, Triazolo Pirimidinas e Tiazolo Pirimidinas. O livro intitulado "Triazolo Quinazolines: Synthesis and Biological Prediction Study" inclui uma revisão exaustiva das reacções de MW e a síntese, caraterização e estudo de previsão biológica de derivados de triazolo quinazolina. O conteúdo dos livros é altamente significativo para os investigadores de química orgânica sintética, heterocíclica, farmacêutica e medicinal.

I derivati di 1, 3, 5-ossadiazina mostrano attività acricida, antibatterica, cardiovascolare, miticida e nematocida, insetticida, regolatrice della crescita delle piante e anticonvulsivante. Inoltre, le ossadiazine sono intermedi vantaggiosi nella sintesi di prodromi di tenidap o antibiotici ¿-lattamici, carbapenemi e penematici. L'indoxacarb, un insetticida a base di ossadiazina, blocca i canali del sodio dei neuroni degli insetti. Il promettente potenziale soddisfacente delle ossadiazine ci ha incoraggiato a sintetizzare nuovi derivati di diverse 1,3,5-ossadiazine. Il lavoro è stato una continuazione della serie di dieci libri come Pirimidine, Quinazoline, Pirimidine fuse con anelli eterociclici, Novel Pyrazoles part I, Novel Pyrazoles part II e Triazolo Pyrimidines, Thiazolo pyrimidines, Triazolo Quinazolines, Thiadiazines e Triazines. Il presente libro, intitolato "Oxadiazines: synthesis and biological prediction study" (Ossadiazine: sintesi e studio di previsione biologica), comprende una breve rassegna della letteratura sul significato medicinale, gli approcci sintetici e le applicazioni delle ossadiazine. Il capitolo 2 comprende la sintesi, la caratterizzazione e lo studio di previsione biologica dei derivati dell'ossadiazinano-4-tione.

Les dérivés de la 1, 3, 5-Oxadiazine présentent des activités acricides, antibactériennes, cardiovasculaires, miticides et nématocides, insecticides, régulatrices de la croissance des plantes et anticonvulsives. En outre, les oxadiazines sont des intermédiaires avantageux dans la synthèse de prodrogues de tenidap ou d'antibiotiques ¿-lactamines, de carbapénèmes et de pénèmes. L'indoxacarbe, un insecticide à base d'oxadiazine, bloque les canaux sodiques neuronaux des insectes. Le potentiel satisfaisant et prometteur des oxadiazines nous a encouragés à synthétiser de nouveaux dérivés de plusieurs 1,3,5-oxadiazines. Ce travail s'inscrit dans la continuité des dix livres intitulés Pyrimidines, Quinazolines, Pyrimidines fusionnées avec des anneaux hétérocycliques, Novel Pyrazoles part I, Novel Pyrazoles part II et Triazolo Pyrimidines, Thiazolo pyrimidines, Triazolo Quinazolines, Thiadiazines et Triazines. Le présent ouvrage, intitulé "Oxadiazines : synthesis and biological prediction study" (Oxadiazines : synthèse et étude de prédiction biologique), comprend une brève étude de la littérature sur l'importance médicinale, les approches synthétiques et les applications des oxadiazines. Le chapitre 2 comprend la synthèse, la caractérisation et l'étude de prédiction biologique des dérivés de l'oxadiazinane-4-thione.

Los derivados de 1, 3, 5-oxadiazina presentan actividades acaricida, antibacteriana, cardiovascular, acaricida y nematocida, insecticida, reguladora del crecimiento vegetal y anticonvulsiva. Además, las oxadiazinas son intermedios ventajosos en la síntesis de profármacos tenidap o antibióticos ¿-lactámicos, carbapenems y penems. Se ha comunicado que el Indoxacarb, un insecticida a base de oxadiazina, bloquea los canales de sodio neuronales de los insectos. El prometedor potencial satisfactorio de las oxadiazinas nos animó a sintetizar nuevos derivados de varias 1,3,5-oxadiazinas. El trabajo ha sido una continuación de nuestro trabajo de la serie de diez libros como Pyrimidines, Quinazolines, Pyrimidines fused with heterocyclic rings, Novel Pyrazoles part I, Novel Pyrazoles part II and Triazolo Pyrimidines, Thiazolo pyrimidines , Triazolo Quinazolines, Thiadiazines and Triazines. El presente libro titulado "Oxadiazines: synthesis and biological prediction study" (Oxadiazinas: síntesis y estudio de predicción biológica) comprende un breve estudio de la bibliografía sobre la importancia medicinal, los enfoques sintéticos y las aplicaciones de las oxadiazinas. El capítulo 2 comprende la síntesis, caracterización y estudio de predicción biológica de derivados de oxadiazinano-4-tiona.

Os derivados de 1, 3, 5-Oxadiazina apresentam actividades acricidas, antibacterianas, cardiovasculares, miticidas e nematocidas, insecticidas, reguladoras do crescimento das plantas, e anticonvulsivas. Além disso, as oxadiazinas são intermediários vantajosos na síntese de tenidap prodrugs ou ¿-lactam antibióticos, carbapenems e penems. Transmite-se que o Indoxacarb, um insecticida de oxadiazina, bloqueia os canais neuronais de sódio dos insectos. O potencial de satisfação promissor das oxadiazinas encorajou-nos a sintetizar novos derivados de várias 1,3,5-oxadiazinas. O trabalho tem sido uma continuação do nosso trabalho da série de dez livros como Pyrimidines, Quinazolines, Pyrimidines fundidas com anéis heterocíclicos, Novel Pyrazoles parte I, Novel Pyrazoles parte II e Triazolo Pyrimidines, Thiazolo pyrimidines , Triazolo Quinazolines, Thiadiazines e Triazines. O presente livro intitulado "Oxadiazinas: estudo de síntese e previsão biológica", que inclui um breve levantamento da literatura tomada para significado medicinal, Abordagens Sintéticas e Aplicações das oxadiazinas. O capítulo-2 compreende o Estudo de Síntese, Caracterização e Predição Biológica dos derivados de Oxadiazinano-4-ioneiros.

1,3,5-Oxadiazin-Derivate zeigen akzidale, antibakterielle, kardiovaskuläre, mitizide und nematozide, insektizide, pflanzenwachstumsregulierende und krampflösende Wirkungen. Darüber hinaus sind Oxadiazine vorteilhafte Zwischenprodukte bei der Synthese von Tenidap-Prodrugs oder ¿-Lactam-Antibiotika, Carbapenemen und Penemen. Es wird berichtet, dass Indoxacarb, ein Oxadiazin-Insektizid, die neuronalen Natriumkanäle von Insekten blockiert. Das vielversprechende und zufriedenstellende Potenzial der Oxadiazine hat uns dazu ermutigt, neue Derivate verschiedener 1,3,5-Oxadiazine zu synthetisieren. Die Arbeit war eine Fortsetzung unserer Arbeit aus der Serie von zehn Büchern wie Pyrimidine, Quinazoline, Pyrimidine fusioniert mit heterozyklischen Ringen, Novel Pyrazoles part I, Novel Pyrazoles part II und Triazolo Pyrimidine, Thiazolo Pyrimidine, Triazolo Quinazoline, Thiadiazine und Triazine. Das vorliegende Buch mit dem Titel "Oxadiazine: Synthese und biologische Vorhersagestudie" enthält einen kurzen Überblick über die Literatur zur medizinischen Bedeutung, synthetische Ansätze und Anwendungen von Oxadiazinen. Kapitel 2 umfasst die Synthese, Charakterisierung und biologische Vorhersagestudie von Oxadiazinan-4-thion-Derivaten.

Pyrazoles represent one of the most active classes of compounds possessing wide Spectrum of biological activities, hence have a long history of applications in agrochemicals and pharmaceutical industry as herbicides and active pharmaceuticals. Microwave irradiation as an unconventional energy source offers reduced chemical reaction times from hours to minutes, reduced side reactions, increased yield and improved reproducibility. Multi-component reactions under microwave irradiation often create complete and complex molecular products in a single synthetic step. The work has been a continuation of our work from the series of three books comprising of synthesis and QSAR study of Pyrimidine derivatives, Pyrimidines fused with heterocyclic rings and Quinazolines. This fourth book entitled "Novel Pyrazole derivatives: Part I: Literature Survey of Pyrazoles and Microwave Assisted Organic Synthesis¿ comprises of the literature Survey of pyrazoles and that of Microwave Assisted Organic Synthesis. The content in the books is highly significant for the researchers and students of synthetic organic, heterocyclic, pharmaceutical & medicinal chemistry.

Pyrazoles represent one of the most active classes of compounds possessing wide Spectrum of biological activities. Microwave irradiation as an unconventional energy source offers reduced chemical reaction times, reduced side reactions, increased yield and improved reproducibility. Multi-component reactions under microwave irradiation often create complete and complex molecular products in a single synthetic step. The present work has been a continuation of our work from the series of four books comprising of synthesis and QSAR study of Pyrimidine derivatives, Pyrimidines fused with heterocyclic rings, Quinazolines and Novel Pyrazole derivatives: Part I. The Present book entitled as "Novel Pyrazole derivatives: Part II: Synthesis and Biological Prediction Study¿ comprises of Chapters 1 to 5 which describe in detail the synthesis, characterization and biological prediction study of bipyrazolyl derivatives, pyrazolyl thiazines, pyrazol-1-yl-thiazolidin-4-one, pyrazolyl amino pyrazoles, pyrazolo pyrazoles respectively. The content in the books is highly significant for the researchers and students of synthetic organic, heterocyclic, pharmaceutical & medicinal chemistry.

Pyrimidine and its derivatives exhibiting pharmacological and therapeutic properties such as anti-inflammatory, antiviral, antibacterial, antitumor, calcium channel antagonist, antihypertensive and anticancer activities etc have attracted interest in medicinal chemistry. MCRs are of increasing importance in organic and medicinal chemistry, in times where a premium is put on speed, diversity and efficiency in the drug discovery process. MCRs are of increasing importance in organic and medicinal chemistry in times where a premium is put on speed, diversity, and efficiency in the drug discovery process. The work has been a continuation of our work from the series of five books namely Pyrimidines, Quinazolines, Pyrimidines fused with heterocyclic rings, Novel Pyrazoles part I and Novel Pyrazoles part II. The book entitled ¿TriazoloPyrimidines: Synthesis and Biological Prediction Study¿ comprises of the literature Survey of Multicomponent Reactions (MCR) and the Synthesis, Characterization and Biological Prediction Study of Triazolo Pyrimidine Derivatives. The content in the books is highly significant for the researchers and students of synthetic heterocyclic pharmaceutical Chemistry

Thiadiazines are six-membered heterocyclic compounds with two nitrogens and one sulphur atom. Diverse biological effects are associated with thiadiazines bearing hetero atoms at 1,2,4 or 1,3,4 positions. The work has been a continuation of our work from the series of eight books as Pyrimidines, Quinazolines, Pyrimidines fused with heterocyclic rings, Novel Pyrazoles part I, Novel Pyrazoles part II and Triazolo Pyrimidines, Thiazolo pyrimidines and Triazolo Quinazolines. The present book entitled ¿Thiadiazines: synthesis and biological prediction study¿ includes a brief survey of the literature taken for medicinal significance and Synthetic Approaches and Applications of thiadiazines and the Synthesis, Characterization and Biological Prediction Study of thiadiazin-2-yl-thiazolidin-4-one derivatives.

1,2,4-Triazines and their derivatives have been widely studied in terms of their synthetic methodologies and reactivity, since some of these derivatives were reported to have promising biological activities as muscle relaxant, hypoglycemic, blood pressure depressant, anti-diabetic properties, anti-tumor, anti-bacterial, hormone antagonists, anti-leukemic, anti-inflammatory, neuro protective, antimalarial, anticancer, antifungal, anticonvulsant, antibacterial, antiviral, herbicidal, sea water algicidal, fungicidal, insecticidal and pesticidals. The work has been a continuation of our work from the series of nine books as Pyrimidines, Quinazolines, Pyrimidines fused with heterocyclic rings, Novel Pyrazoles part I, Novel Pyrazoles part II and Triazolo Pyrimidines, Thiazolo pyrimidines , Triazolo Quinazolines and Thiadiazines. The present book entitled ¿Triazines: Synthesis and Biological Prediction Study¿ includes a brief survey of the literature taken for medicinal Significance, Synthetic Approaches and Applications of triazines and the Synthesis, Characterization and Biological Prediction Study of 3-thioxo-1,2,4-triazin-5-one Derivatives.

Microwave irradiation has gained popularity in the past decade as a powerful tool for rapid and efficient synthesis of a variety of compounds with enhanced reaction rate and improved product field in chemical synthesis and formation of a variety of carbon-heteroatom bonds. The quinazoline moiety is a building block for about 150 naturally occurring alkaloids and drugs. Quinazoline ring systems have a prominent feature in medicinal chemistry and possess biological activities such as antimalarial, anticonvulsant, antibacterial, antidiabetic, and anticancer. The work has been a continuation of our work from the series of seven books namely Pyrimidines, Quinazolines, Pyrimidines fused with heterocyclic rings, Novel Pyrazoles part I and Novel Pyrazoles part II, Triazolo Pyrimidines and Thiazolo Pyrimidines. The book entitled ¿Triazolo Quinazolines: Synthesis and Biological Prediction Study¿ includes a comprehensive review of MW reactions and the Synthesis, Characterization and Biological Prediction Study of Triazolo Quinazoline Derivatives. The content in the books is highly significant for the researchers of synthetic organic, heterocyclic, pharmaceutical & medicinal chemistry.

Pyrimidine and its derivatives reside a distinctive and exclusive position in human existence with great biological and medicinal significance such as anti-inflammatory, antiviral, antibacterial, antitumor, calcium channel antagonist, antihypertensive and anticancer activities. Trusting in mind a variety of biomedical uses and pharmacological profile, various 1,2,4-triazolo pyrimidines, thiazolo[3,2-a]pyrimidines and substituted quinazolinone were prepared and screened for their biological actions after their biological prediction studies. The work has been a continuation of our work from the series of six books namely Pyrimidines, Quinazolines, Pyrimidines fused with heterocyclic rings, Novel Pyrazoles part I and Novel Pyrazoles part II and Triazolo Pyrimidines. The book entitled ¿Thiazolo Pyrimidines : Synthesis and Biological Prediction Study¿ comprises of the literature Survey of Pyrimidnes and the Synthesis, Characterization and Biological Prediction Study of Thiazolo Pyrimidine Derivatives. The content in the books is highly significant for the researchers and students of synthetic organic, heterocyclic, pharmaceutical & medicinal chemistry.

Pyranochromen-2-ones are the class of chromen-2-ones which contain a pyran ring fused with that of chromen-2-one. Pyranochromen-2-ones and their analogues are a large class of compounds that have attracted the interest due to their biological activities and have shown few medical uses as pharmaceuticals, such as in the treatment of lymphedema. They also have ability to increase plasma antithrombin levels. The work has been a continuation of our work from the series of thirteen books as Pyrimidines, Quinazolines, Pyrimidines fused with heterocyclic rings, Novel Pyrazoles part I, Novel Pyrazoles part II ,Triazolo-Pyrimidines, Thiazolo-pyrimidines, Triazolo-Quinazolines, Triazines, Thiadiazines, Oxadiazines, Chromenes and Pyrano Pyrimidines. The present book entitled ¿Pyrano Chromenes: Significance and Strategies for synthesis¿ has a brief survey of the literature taken for Pyrano Chromenes, Introduction to Heterocyclic Organic Chemistry followed by DBN as catalyst. Chapter-4 describes application of malononitrile for the synthesis of pyrano[3,2-c]chromene-3-carbonitrile derivatives.

Pyrimidines fused with pyran ring are called pyranopyrimidines. The fusion is necessarily at the 4, 5 or 5, 6 carbon atoms from the pyrimidine ring. The pyranopyrimidine derivatives have immense importance in synthesis as well as in biological chemistry. Various pyrano pyrimidines are present in alkaloids, carbohydrates, polyether antibiotics and natural products. The pyrano pyrimidines possess several antimicrobial, antifungal and potent in-vitro antibacterial activities. The work has been a continuation of our work from the series of twelve books as Pyrimidines, Quinazolines, Pyrimidines fused with heterocyclic rings, Novel Pyrazoles part I, Novel Pyrazoles part II and Triazolo-Pyrimidines, Thiazolo-pyrimidines, Triazolo-Quinazolines, Triazines, Thiadiazines, Oxadiazines and Chromenes. The present book entitled ¿Pyrano Pyrimidines: Significance and Strategies for synthesis¿ has a brief survey of the literature taken for pyrano pyrimidines, microwaves in organic chemistry, synthetic applications of malononitriles and PSSA as catalyst. Chapter-5 describes Applications of malononitrile for the synthesis of pyrano[2,3-d] pyrimidine-6-carbonitrile derivatives.

Chromene or Benzopyran is an important class of organic compounds which have attracted much attention due to their pharmacological importance, such as use in thermoplastic resins, anticorrosive and antifertility treatment, estrogenic agents and in angina pectoris. The 2H-1-benzopyrans are considered to be antidepressant, antianexial, analgesic, antioxidant, hupoglycemic, antihypertensive, and antitumor agents. The work has been a continuation of our work from the series of eleven books as Pyrimidines, Quinazolines, Pyrimidines fused with heterocyclic rings, Novel Pyrazoles part I, Novel Pyrazoles part II and Triazolo-Pyrimidines, Thiazolo-Pyrimidines, Triazolo-Quinazolines, Triazines, Thiadiazines and Oxadiazines. The present book entitled ¿Chromenes: Significance and Strategies for synthesis¿ has a brief survey of the literature taken for Chromenes, Introduction to Nitriles followed by Synthetic applications of ethyl cyanoacetate and Ionic liquids as catalyst. Chapter 5 describes application of ethyl cyanoacetate for the synthesis of tetrahydro-4H-chromene-3-carboxylic acid ethyl ester derivatives.

1, 3, 5-Oxadiazine derivatives display acricidal, antibacterial, cardiovascular, miticidal and nematocidal, insecticidal, plant growth regulating, and anticonvulsive activities. In addition, oxadiazines are advantageous intermediates in the synthesis of tenidap prodrugs or ¿-lactam antibiotics, carbapenems and penems. It is conveyed that Indoxacarb, an oxadiazine insecticide blocks insect neuronal sodium channels. The promising satisfying potential of oxadiazines encouraged us to synthesize novel derivatives of several 1,3,5-oxadiazines. The work has been a continuation of our work from the series of ten books as Pyrimidines, Quinazolines, Pyrimidines fused with heterocyclic rings, Novel Pyrazoles part I, Novel Pyrazoles part II and Triazolo Pyrimidines, Thiazolo pyrimidines , Triazolo Quinazolines, Thiadiazines and Triazines. The present book entitled ¿Oxadiazines: synthesis and biological prediction study¿ which comprises a brief survey of the literature taken for medicinal significance , Synthetic Approaches and Applications of oxadiazines. Chapter-2 comprises the Synthesis, Characterization and Biological Prediction Study of Oxadiazinane-4-thione derivatives.