Bücher von Shweta Rastogi

There is a need to develop new methods to synthesize nanoparticles. Interest in these products has led to concerns about the environmental safety of their production; Objective: Currently, nanoparticle production is often expensive and uses chemicals that have an impact on the environment and requires the development of ¿greener¿ protocols. Here, we describe the synthesis of gold nanoparticles (AuNPs) using plant extracts, an alternative, effective, inexpensive and environmentally friendly method to create nanoparticle geometries. Method: phytochemicals present in the aqueous leaf extract act as powerful reducing agents. Produced AuNPs can be used in transmission electron microscopy (TEM), scanning electron microscopy (SEM), atomic force microscopy (AFM), X-ray diffraction (XRD), ultraviolet visible spectroscopy, energy dispersive X-ray (EDX) and Thermogravimetric Analysis (TGA); Results and Conclusion: The prepared nanoparticles have been shown to be biocompatible and exhibit no bacterial or antiviral activity, so they are considered safe for many applications in nano medicine.

Quinazolines are well known for their pharmaceutical importance as antibacterials, antitumours, antiparkinson and also show blood platelet antiaggregating activities. The Niementowski reaction is the explored for the synthesis of 3- substituted-4(3H)quinazolinones for which anthranilic acid, formic acid and aromatic or heteroaromatic amines are irradiated using ¿neat reaction technology¿ under microwaves without any solvent. This proved to be a high yielding protocol. Further study of 4(3H)quinazolinones as another possible Niementowski reaction is done by irradiating neat reactants, anthranilic acid, aromatic or aliphatic carboxylic acids and aromatic or heteroaromatic amines in microwaves to afford 2,3-disubstituted- 4(3H)quinazolinones within few minutes of irradiation.