Bücher von Sourav De

This book gathers extended versions of papers presented at DoSIER 2021 (the 2021 Third Doctoral Symposium on Intelligence Enabled Research, held at Cooch Behar Government Engineering College, West Bengal, India, during November 12-13, 2021). The papers address the rapidly expanding research area of computational intelligence, which, no longer limited to specific computational fields, has since made inroads in signal processing, smart manufacturing, predictive control, robot navigation, smart cities, and sensor design, to name but a few. Presenting chapters written by experts active in these areas, the book offers a valuable reference guide for researchers and industrial practitioners alike and inspires future studies.

In the recent past tetralone have aroused great interest in the field of drug discovery owing to their wide applications as analgesic, antidepressant, antifungal and antibacterial. It is an ubiquitous structural feature of many alkaloid natural products and viable drug candidates. Pharmacological effect of potential drugs depends sensitively on the stereochemistry and ring conformation especially in the case of 4 substituted tetralone. Antidepressants are drugs which can elevate mood in depressive illness. Practically all depressants affect monoaminergic transmission in the brain. Tricyclic antidepressants (TCAs) are a group of drugs used to treat affective, or ¿mood¿, disorders. Mood disorders are associated with reduced levels of monoamines in the brain. TCA binding to 5-HT and noradrenaline re-uptake transporters prevents the re-uptake of these monoamines from the synaptic cleft and their subsequent degradation. This re-uptake blockade leads to the accumulation of 5-HT and noradrenaline in the synaptic cleft and the concentration returns to within the normal range