Bücher von SRDJAN M VLAJKOVIC

The sense of hearing is vulnerable to environmental challenges, such as exposure tonoise. More than 1.5 billion people experience some decline in hearing ability during theirlifetime, of whom at least 430 million will be affected by disabling hearing loss. If notidentified and addressed in a timely way, hearing loss can severely reduce the quality oflife at various stages. Some causes of hearing loss can be prevented, for example fromoccupational or leisure noise. The World Health Organization estimates that more than 1billion young people put themselves at risk of permanent hearing loss by listening to loudmusic over long periods of time. Mitigating such risks through public health action isessential to reduce the impact of hearing loss in the community. The etiology ofsensorineural hearing loss is complex and multifactorial, arising from congenital andacquired causes. This book highlights the diverse range of approaches to sensorineuralhearing loss, from designing new animal models of age-related hearing loss, to the use ofmicroRNAs as biomarkers of cochlear injury and drug repurposing for the therapy of agerelatedand noise-induced hearing loss. Further investigation into the underlyingmolecular mechanisms of sensorineural hearing loss and the integration of the noveldrug, cell, and gene therapy strategies into controlled clinical studies will permitsignificant advances in a field where there are currently many unmet needs.