Bücher von Srinivasa Rao Yarguntla

Six formulations of modified pulsincap of Indomethacin were developed by using various grades and ratios by using Hydroxy propyl methyl cellulose K-100M, CCS as rate controlling polymers. Magnesium sterate and talc are the other components used. Blends were evaluated for various parameters such as bulk density, tapped density,angle of repose, Hausners ratio, Carr¿s index. Capsules were evaluated for their physical appearance,drug content, % weight variation and Invitro drug release. All the physico chemical properties are with in the acceptable limits. Based on the results, formulation F6 containing HPMC-K100M in the concentration double the drug¿s concentration was identified as an ideal and better formulation among all formulations. In-vitro release of an optimized formulation of Indomethacin (f6) was found to be 96.05% in 4hrs. Based on the regression coefficient (R2 ) values of various plots, the optimized formulation was found to follow First-order release model and mechanism of drug release was non-fickian type of diffusion based on ¿n¿ value of Korsemeyer-Peppas model.

The main aim of the present investigation was to formulate and characterize a ¿-cyclodextrin loaded indomethacin mouth dissolving film to bypass the first pass metabolism Indomethacin is a non-steroidal anti-inflammatory agent (NSAIA) with anti-inflammatory, analgesic, antipyretic activity. Its pharmacological effect is thought to be mediated through inhibition of the enzyme cyclooxygenase (COX), the enzyme responsible for catalyses the rate-limiting step in prostaglandin synthesis via the arachidonic acid pathway. indomethacin- ¿ cyclodextrin loaded mouth dissolving film prepared by solvent evaporation technique with various hydrophilic polymers like hydroxyl Propyl methyl cellulose (HPMC) 15cps, HPMC K100M, SLS(sodium lauryl sulphate), and PEG 400 & PEG 600.The formulated mouth dissolving film were evaluated for their physiochemical parameters like weight variation, thickness, folding endurance, drug content, moisture content and moisture absorption. In vitro drug release was carried out by dissolution apparatus. All these mouth dissolving film were shows >70% of drug released within half an hour and obeyed first order release kinetics.

All the formulations were prepared by direct compression method. The prepared tablets of all the formulations were evaluated for physical characters, assay, in¿vitro drug release, swelling index, hardness and friability. The main aim was to optimize the formulation for 1-12 hours in¿vitro release. Optimized formulation F9 containing chitosan and xanthan gum in 1:1 ratio shows better drug release up to 12hours was consider as the best product with respect to in-vitro drug release for 12 hours release action and improved site¿specific action. The results showed that the drug release rate was decreased as the viscosity of the polymer was increased. The drug release kinetics was performed for the optimized formulation and it shows zero order with super case II transport drug release.