Bücher von Ton J. Cleophas

IBM (international business machines) has published in its SPSS statistical software 2022 update a very important novel regression method entitled Kernel Ridge Regression (KRR). It is an extension of the currently available regression methods, and is suitable for pattern recognition in high dimensional data, particularly, when alternative methods fail. Its theoretical advantages are plenty and include thekernel trick for reduced arithmetic complexity,estimation of uncertainty by Gaussians unlike histograms,corrected data-overfit by ridge regularization,availability of 8 alternative kernel density models for datafit.A very exciting and wide array of preliminary KRR research has already been published by major disciplines (like studies in quantum mechanics and nuclear physics, studies of molecular affinity / dynamics, atomisation energy studies, but also forecasting economics studies, IoT (internet of things) studies for e-networks, plant stress response studies, big data streaming studies, etc). In contrast, it is virtually unused in clinical research. This edition is the first textbook and tutorial of kernel ridge regressions for medical and healthcare students as well as recollection / update bench, and help desk for professionals. Each chapter can be studied as a standalone, and, using, real as well as hypothesized data, it tests the performance of the novel methodology against traditional regression analyses. Step by step analyses of over 20 data files stored at Supplementary Files at Springer Interlink are included for self-assessment. We should add that the authors are well qualified in their field. Professor Zwinderman is past-president of the International Society of Biostatistics (2012-2015) and Professor Cleophas is past-president of the American College of Angiology (2000-2002). From their expertise they should be able to make adequate selections of modern KRR methods for the benefit of physicians, students, and investigators. The authors have been working and publishing together for 24 years and their research can be characterized as a continued effort to demonstrate that clinical data analysis is not mathematics but rather a discipline at the interface of biology and mathematics.

Machine learning is a novel discipline concerned with the analysis of large and multiple variables data. It involves computationally intensive methods, like factor analysis, cluster analysis, and discriminant analysis. It is currently mainly the domain of computer scientists, and is already commonly used in social sciences, marketing research, operational research and applied sciences. It is virtually unused in clinical research. This is probably due to the traditional belief of clinicians in clinical trials where multiple variables are equally balanced by the randomization process and are not further taken into account. In contrast, modern computer data files often involve hundreds of variables like genes and other laboratory values, and computationally intensive methods are required. This book was written as a hand-hold presentation accessible to clinicians, and as a must-read publication for those new to the methods.

The current textbook has been written as a help to medical / health professionals and students for the study of modern Bayesian statistics, where posterior and prior odds have been replaced with posterior and prior likelihood distributions.

Step by step statistics for self-assessments are includedThe authors conclude, that machine learning is often more informative, and provides better sensitivities of testing than traditional analytic methods do

In contrast, the adverse effect "increased calorie intake" occurs with "increased exercise", and this adverse effect is very dependent on the main outcome "weight loss".

The current textbook has been written as a help to medical / health professionals and students for the study of modern Bayesian statistics, where posterior and prior odds have been replaced with posterior and prior likelihood distributions.

The current edition is the first textbook in the field of meta-analysis entirely written by two clinical scientists, and it consists of many data examples and step by step analyses, mostly from the authors' own clinical research.

Adequate health and health care will, however, soon be impossible without proper data supervision from modern machine learning methodologies like cluster models, neural networks and other data mining methodologies.Each chapter starts with purposes and scientific questions.

Third, the authors felt that the chapter texts needed some improvements for better readability: chapters have now been classified according the outcome data helpful for choosing your analysis rapidly, a schematic overview of data, and explanatory graphs have been added.

This book covers all relevant pocket calculator statistical methods, making it an ideal resource for those who wish to understand statistics but have no time for complex mathematics. It helps facilitate data analysis by detailing pocket calculator methods.

Unique features of the book involve the following. 1.This book is the third volume of a three volume series of cookbooks entitled "Machine Learning in Medicine - Cookbooks One, Two, and Three".

Offering sequenced guidance for non-specialists on how to reap the benefits of machine learning in medicine and healthcare, this text harnesses the power of cutting-edge computing to maximize the accessibility and analytic value of stored data and records.

This timely guide explains how to derive the most benefit from automatically mining the vast, and growing, quantities of information in medical databases. It lays out the fruits of the authors' expertise in a condensed, easily consulted format.

This book contains all statistical tests relevant for starters on SPSS. Each test is explained using a data example from clinical practice along with the main tables of results with an accompanying text with interpretations of the results and hints.

This second of a two-volume work includes coverage of various clustering models, support vector machines, Bayesian networks, discrete wavelet analysis, genetic programming, association rule learning, anomaly detection and correspondence analysis.

This book presents the latest developments in the field of clinical data analysis. It emphasizes non-classical but increasingly frequently used methods such as equivalence testing, interaction assessment and analysis of genetic data.

This book covers all relevant pocket calculator statistical methods, making it an ideal resource for those who wish to understand statistics but have no time for complex mathematics. It helps facilitate data analysis by detailing pocket calculator methods.

It is important for anyone who is involved in clinical research: clinicians, pharmacists, biochemists, statisticians, nurses, sponsors, etc., and anyone who is involved in applying results of research to patients, i.e.

The first part of this title contained all statistical tests relevant to starting clinical investigations, and included tests for continuous and binary data, power, sample size, multiple testing, variability, confounding, interaction, and reliability.

The book has been produced with the same size and frontpage as the textbook "Statistics Applied To Clinical Trials" by the same authors and edited by same publishers ( 2nd Edition, DordrechtiBostonlLondon, 2002), and can be applied together with the current self-assessment book or separately.

The first part of this title contained all statistical tests that are relevant for starters on SPSS, and included standard parametric and non-parametric tests for continuous and binary variables, regression methods, trend tests, and reliability and validity assessments of diagnostic tests.