Bücher der Reihe Advances in Anatomy, Embryology and Cell Biology

To exemplify this, he formulated a universal and purely formal law of growth in mathematical terms making the comment: "I now suggest that the body form follows immediately from germinal growth and can be derived from the given germinal form according to the laws of growth.

Though more than 300 years have elapsed since the first description of the peculiar course of the spinal accessory (XI) nerve by Willis (1664), the crucial problems concerning what is known as accessory field of musculature and its innervation are still unsolved and a matter of controversy.

Emphasis is particularly placed on the organization of subsections of the Golgi apparatus and the questions of how Golgi subsections may be related to functional subcompartments of the Golgi system.

Histological observations of human embryos hitherto have been carried out using paraffin sections of 5 to 10 m thickness, stained with the H-E method or simply with carmine. The thinness of sections and clearness of staining reveal the histological details of this embryo very accurately.

Rhythmic changes in physiology and behaviour within a 24 h period occur in living organisms on earth to meet the challenges associated with the daily changes in the external environment.

As a draining and secretory system, the nasolacrimal ducts play a role in tear transport and non-specific immune defense. In this book recent advances about the nasolacrimal ducts have been summarized and discussed in context with nasolacrimal duct pathophysiology.

Based on their 'neurochemical coding', morphology, location and origin, three sensory receptor end organs are currently morphologically well-characterised: smooth muscle-associated airway receptors (SMARs), neuroepithelial bodies (NEBs) and visceral pleura receptors (VPRs).

This book describes the structures of Metallothionein (MT) family members and the cellular functions of MT-1, MT-2 and MT-4 isoforms, as well as provides insights into divergent biological roles of MT-3.

This volume of Advances Anatomy Embryology and Cell Biology focuses on the emerging field of bio-image informatics, presenting novel and exciting ways of handling and interpreting large image data sets.

Over the last decades, acrosomal exocytosis (also called the ¿acrosome reaction¿) has been recognized as playing an essential role in fertilization. Secretion of this granule is an absolute requirement for physiological fertilization. In recent years, the study of mammalian acrosomal exocytosis has yielded some major advances that challenge the long-held, general paradigms in the field. Principally, the idea that sperm must be acrosome-intact to bind to the zona pellucida of unfertilized eggs, based largely on in vitro fertilization studies of mouse oocytes denuded of the cumulus oophorus, has been overturned by experiments using state-of-the-art imaging of cumulus-intact oocytes and fertilization experiments where eggs were reinseminated by acrosome-reacted sperm recovered from the perivitelline space of zygotes. From a molecular point of view, acrosome exocytosis is a synchronized and tightly regulated process mediated by molecular mechanisms that are homologous to those reportedin neuroendocrinal cell secretions. The authors provide a broader perspective, focusing on a limited number of important topics that are essential for understanding the molecular mechanisms governing this step in the fertilization process. They also discuss molecular aspects such as the signaling pathways leading to exocytosis, including the participation of ion channels, lipids, the fusion machinery proteins and the actin cytoskeleton as well as cellular aspects such as the site of acrosomal exocytosis and the use of gene-manipulated animals to study this process.

This book elucidates the mechanisms involved in biological membrane functions. It describes the new modalities and characterization for basic in vitro as well as computer models of biological membranes.

International experts from the field including several members of the EU-AIMS initiative launched by the European Union to develop novel treatments for ASD have contributed chapters on several topics covering all crucial aspects of translational ASD research with a special emphasis on ASD model systems including stem cells and animals.

Herpes viruses maintain themselves within hosts in a latent state resulting in virus persistence for years - usually for the life span of the hosts.

Five leaders in the field of mammalian preimplantation embryo development provide their own perspectives on key molecular and cellular processes that mediate lineage formation during the first week of life. The first cell-fate decision involves the formation of the pluripotent inner cell mass (ICM) and extraembryonic trophectoderm (TE).

This volume provides a comprehensive and updated review of perineuronal satellite cells in sensory ganglia. However, some years ago research findings suggested that satellite cells play a role in the development and maintenance of neuropathic pain. As a result, satellite cells are now considered as possible targets for neuropathic pain treatment.

This book presents an overview of a new group of progenitor stem cells. From here, some of these progenitor cells enter the aorta, are distributed through the vascular system and become the embryonal stem cells (reserve cells) in many peripheral tissues.

This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology is focused on mitochondrial inheritance in humans and both vertebrate and invertrebate animals including Drosophila, C.

This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology focuses on the need for and use of animal models when studying endometriosis.

This new volume of the book series Advances in Anatomy, Embryology and Cell Biology provides a complete and exhaustive overview of the morphofunctional organization of the mammalian carotid body, a polymodal chemosensory organ responsible for the maintenance of blood gas homeostasis. The authors review the state of the art of the neurochemical anatomy of carotid body¿s cell populations with a special reference to their structural and neurochemical plasticity. The essential role of this organ in the generation, progression and maintenance of cardiorespiratory and metabolic diseases in humans and other mammals is presented. Finally, the book summarizes current knowledge on the stem cell niche in the mammalian carotid body and discusses its contribution to replacement cell therapy and other potential applications in translational research. This book represents an essential reading for physiologists, anatomists, cell, and developmental biologists, as wellas physicians, veterinarians, and biomedical researchers.