Bücher der Reihe Advances in Experimental Medicine and Biology

The detailed biological functions of these cytoplasmic structures are still being uncovered and the idea for this book is to provide the history of the discovery and the major work from different laboratories that has led to the characterization and elucidation of the structure and function of these new multiple subcellular structures.

This volume represents a collection of topics on the "novel" functions of complement, patho-physiology, protein structures, design of complement inhibitors, and complement assays discussed during the conference.

Such studies are shedding new light on the pathogenetic mechanism of complement-related diseases such as autoimmune diseases and inflammatory tissue damage as well as defining new areas of high interest such as the developmental biology of complement.

This book illustrates the intimate relationship between alveolar macrophages and Mycobacterium tuberculosis (M.tb.), and the former's role in both innate and adaptive immunity against M.tb. It explores a novel approach to designing a new tuberculosis vaccine.

This book details our progress in understanding the receptor and intracellular signaling mechanisms utilized by semaphorins. The comprehensive overview of semaphorin biology and signaling presented in this book allows one to compare semaphorin functions between different biological systems.

Interest in the chemistry, biochemistry, and safety of acrylamide is running high. These proceedings contain presentations by experts from eight countries on the chemistry, analysis, metabolism, pharmacology, and toxicology of the compound.

Early Life Origins of Health and Disease is a new book which presents and discusses the many factors that may have impact on normal development. Finally, new and emerging evidence for other areas of human health and disease such a motor control and mental health is critically reviewed for the first time.

In contrast, lipid A has been tested in over 300,000 individuals in various vaccines trials, including therapeutic cancer vaccines.Clearly most of the work needed to develop lipid A as effective anti-cancer agents and/or as vaccine adjuvant lies ahead in the near future.

Health problems such as hypertension, tendency to diabetes, obesity, blood lipids, vascular disease, bone health, behaviour and learning and longevity may be 'imprinted' during early life. This process is defined as 'programming' whereby a nutritional stimulus operating at a critical, sensitive period of pre and postnatal life imprints permanent effects on the structure, physiology and metabolism.For this reason, academics and industry set-up the EC supported Scientific Workshop -Early Nutrition and its Later Consequences: New Opportunities. The prime objective of the Workshop was to generate a sound exchange of the latest scientific developments within the field of early nutrition to look for opportunities for new preventive health concepts. Further, a closer look was taken at the development of food applications which could provide (future) mothers and infants with improved nutrition that will ultimately lead to better future health. The Workshop was organised by the Dept. of Pediatrics, University of Munich, Germany in collaboration with the Danone Institutes and the Infant Nutrition Cluster, a collaboration of three large research projects funded by the EU.

This book offers an updated review of the physiology of the carotid body chemoreceptors. It provides the trends in the field as it contains results in the topics that are at the frontiers of future developments in O2-sensing in chemoreceptor cells.

Kisspeptin has been shown to be both necessary and sufficient for activation of the reproductive axis, during puberty and later in adulthood. This places kisspeptin neurons in a unique position to be key nodal points and conduits for conveying numerous endogenous and exogenous signals to the reproductive axis.

Proceedings of an international workshop held in Hamburg, Germany, May 19-23, 1996

Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs.

Proceedings of the Ninth International Conference on Lymphocyte Activation and Immune Regulation held on February 8-10, 2002 in Newport Beach, California, U.S.A

Advances in biochemistry, cell biology, genome-wide mutagenesis - coupled with molecular technology, including gene microarray and transgenic and knock-out animals - have been instrumental in understanding the cellular processes and molecular pathways of self-tolerance and autoimmune diseases.

Scientists and clinicians attending the last "New Directions in Antiviral Therapy" conference in late 1994 could hardly have predicted the revolution in the management of patients with HIV infection that has occurred since.

Proceedings of an American Chemical Society symposium held in San Francisco, California, April 14 - 18, 1997

Proceedings of a satellite meeting of the European Human Genetic Society held in Sestri Levante, Italy, May 21-25, 1997

The present volume collects 75 papers which were presented during the yth symposium, thus providing a comprehensive view of the state of the art ofCoronavirology. New sequence data about as yet poorly studied coronaviruses - canine coronavirus CCY and porcine epidemic diarrhoea virus PEDY - are presented.

The control and normal regulation of the immune system at the cellular-molecular interface and the great majority of antigens asso ciated with immune disorders are attributed to protein molecules.

The Fifth International Symposium on Human Purine and Pyrimidine Metabolism was held in San Diego, California (U.

Major contributions to the knowledge of normal purine metabolism in man have derived from the study of inborn errors in patients with purine disorders, specifically complete and partial hypoxanthine-guanine phosphoribosyltransferase deficiency.

These two volumes, entitled "Purine Metabolism in Man IV" con tain the paper presented at the "IV. Knowledge derived from the study of purine metabolism in relation to lymphocyte function, for instance, has opened up new possibilities for immunomodulation and leukaemia chemotherapy, with eventual conse quences for other types of cancer.

This book seeks to emphasize the importance of molecular technology in the study of neurogenetic mechanisms and to explore the possible relationships between specific cell cell interactions and regulated gene expression in the develop ing nervous ~stem.