Bücher der Reihe Advances in Experimental Medicine and Biology

This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies¿ development and progression, and (2) the therapeutic strategies that are currently being explored to stop or delay disease progression. Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington¿s disease (HD); spinal¿bulbar muscular atrophy (SBMA); and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17).The genetic basis of polyQ disorders is well established and described, and despite important advances that have opened up the possibility of generating genetic models of the disease, the mechanisms that cause neuronal degeneration are still largely unknown and there is currently no treatment available for these disorders. Further, it is believed that the different polyQ may share some mechanisms and pathways contributing to neurodegeneration and disease progression.

Formation of transmembrane pores is a very effective way of killing cells. This book describes how several of the important pore forming toxin families achieve membrane bi- ing and which structural elements are used for formation of transmembrane pores.

Cancer patients have benefitted greatly from recent advances in the drugs, dose regimens, and combinations used to treat their primary tumor and for the treatment or prevention of spread of their disease. With the increase in survival rates, there has emerged a new awareness of these chronic adverse effects.

The respective MIP isoforms that facilitate the transport of these metalloids include members from several clades of the phylogenetic tree, suggesting that metalloid transport is an ancient function within this family of channel proteins.

In his 1894 book, Materials for the Study of Variation, William Bateson coined the term Homoeosis with the following prose: The case of the modification of the antenna of an insect into a foot, of the eye of a Crustacean into an antenna, of a petal into a stamen, and the like, are examples of the same kind.

This book will contain the proceedings of the XIV International Symposium on Retinal Degeneration (RD2010), held July 13-17, 2010, in Mont-Tremblant, Quebec, Canada. and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy.

He titled his Nobel Lecture "Immunological Recognition of Self" emphasizing the central argument of immunological tolerance in "How does the vertebrate organism recognize self from nonself in this the immunological sense-and how did the capacity evolve." The concept of self is linked to the concept of biological self identity.

This edited book is a compilation of findings on the molecular and cellular toxicity of nanoparticles (NPs) in animal cell, human cells, invertebrates.

This volume has a strong focus on homo-oligomerization, which is surprisingly common. However, protein function is so often linked to both homo- and hetero-oligomerization and many heterologous interactions likely evolved from homologous interaction, so this volume also covers many aspects of hetero-oligomerization.

There are many principles and applications of recombinant antibodies for infectious diseases.

Hot Topics in Infection and Immunity IX

This meeting was the fourth in a series, and assembled a team of scientists working on mechanisms by which the innate immune system of the host senses pathogens, the cellular and signaling networks that orchestrate the innate response and antigen presentation and adaptive immunity.

This volume describes chemical approaches to assess ion channel structure, function and pharmacology.

This book will contain a series of solicited chapters that concern with the molecular machines required by viruses to perform various essential functions of virus life cycle.

An increasing number of workers from different fields have turned to insects, fish, worms and other model hosts as facile, ethically expedient, relatively simple, and inexpensive hosts to model a variety of human infectious diseases and to study host responses and innate immunity.

The Second International Conference on the Effects of Noise on Aquatic Life will take place in Ireland August 15-20, 2010. The Second conference will place strong emphasis on recent research results, the sharing of ideas, discussion of experimental approaches, and analysis of regulatory issues.

The International Society for Systems Biology (ISSB) is a society aimed at advancing world-wide systems biology research by providing a forum for scientific discussions and various academic services. The ISSB helps coordinate researchers to form alliances for meeting the unique needs of multidisciplinary and international systems biology research.

Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation.

The aim of this book is to summarize our understanding on the insect nicotinic acetylcholine receptors. We need to be precise in identifying the subunit composition of native insect nicotinic receptor subtypes, their functional properties and physiological roles.

This book attempts to analyze the latest discoveries in sphingolipid biology and how the alteration of their metabolism leads to altered signaling events and to the development of pathobiological disorders, such as cancer, cardiovascular diseases, asthma, diabetes, inflammation and infectious diseases.

This book is a collection of articles written by prominent scientists who gathered in the city of Recife, Brazil, 23-27 October 2010, celebrating the 10th International Symposium on Yersinia.

Book covers course with topics in infectious diseases in children and is intended for Pediatric Infectious disease clinical researchers, trainees, trainers, and all those who manage the research of children with infections and the children themselves.

Biological systems are an emerging discipline that may provide integrative tools by assembling the hierarchy of interactions among genes, proteins and molecular networks involved in sensory systems. The aim of this volume is to provide a picture, as complete as possible, of the current state of knowledge of sensory systems in nature.

These challenges have prompted an intensive search for new prophylactic and therapeutic strategies in order to prevent infants from acquiring HIV infection through breastfeeding. In this book, expert HIV researchers critically review every aspect of this highly evolving and topical subject.

When Foord and his colleagues discovered that a single transmembrane protein called Receptor Activity Modifying Proteins (RAMPs) could modulate the surface expression of GPCRs of the calcitonin family, it widely opened the field of receptor life cycle.

Scientists interested in the regulation and modulation of components of the immune system found a whole variety of NAbs to cytokines with regulatory and protective functions and NAbs that modulate, e.g., dendritic cells, regulatory T cells, B cells and granulocytes.

This book addresses the role of tandem repeat polymorphisms (TRPs) in genetic plasticity, evolution, development, biological processes, neural diversity, brain function, dysfunction and disease.

Conversely, medical doctors who want to update their knowledge of NPC biology will benefit from chapters on viral and cellular oncogenesis and various aspects of host-tumor interactions.