Bücher der Reihe Advances in Experimental Medicine and Biology

This volume covers recent progress in breast cancer research. It explores breast cancer, the factors that make it lethal and current research progress, including stem cells, microRNAs, epigenetics, genomics and some novel signaling pathways .

This second edition of the book on Store-operated Ca2+ Entry Pathways has been updated with the newest discoveries that emerged in the field within the last five years.

There are many principles and applications of recombinant antibodies for infectious diseases.

There are several types of damage that can be found in the male gamete. The purpose of this book is to provide a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects.

The cannabinoid system plays a central role in a wide variety of physiological functions that touch upon cardiovascular, gastrointestinal, immune, and nervous systems.

The book focuses on protein allostery in drug discovery. Allosteric regulation, 'the second secret of life', fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery-as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and networks, characteristics of allosteric proteins, modulators, and sites, development of computational and experimental methods to predict allosteric sites, small-molecule allosteric modulators of protein kinases and G-protein coupled receptors, engineering allostery, and the underlying role of allostery in precise medicine. Comprehensive understanding of protein allostery is expected to guide the rational design of allosteric drugs for the treatment of human diseases. The book would be useful for scientists and students in the field of protein science and Pharmacology etc.

This volume is the first-ever complete treatise on polymyxins and presents the most comprehensive and up-to-date reviews of all major research and clinical topics from chemistry, microbiology, pharmacology, clinical use, to drug discovery. All chapters were written by internationally leading researchers and clinicians in the field.It is our wish that readers discover the importance of polymyxin structure in relation to the mechanisms of activity, resistance and toxicity. We emphasized that reliable analytic methods for polymyxins are critical when investigating their pharmacokinetics (PK) and pharmacodynamics (PD). The complicated dose definitions and different pharmacopoeial standards have already compromised the safe use of polymyxins in patients. Therefore, informed by the latest pharmacological information, scientifically-based dosing recommendations have been proposed for intravenous polymyxins. Considering the PK/PD limitations and potential development of resistance, polymyxin combinations are encouraged; however, the current literature has not shown definite microbiological benefits, possibly because most clinical studies to date overlooked key PK/PD principles. Nephrotoxicity is the major dose-limiting factor and it is imperative to elucidate the mechanisms and develop novel approaches to minimize polymyxin-associated toxicities. In addition, the anti-endotoxin effect of polymyxins supports their clinical use to treat Gram-negative sepsis. Fortunately, the discovery of new-generation polymyxins with wider therapeutic windows has benefited from the latest achievements in polymyxin research.This book provides extensive pharmacological information on polymyxins to infectious diseases clinicians, pharmacists, clinical microbiologists, antimicrobial pharmacologists, and pharmaceutical scientists, and is an essential read for those who aim to develop novel polymyxins and improve their clinical use as a last-line defense against Gram-negative 'superbugs'.

This book introduces readers to the biology of leukemia stem cells (LSCs) and emphasizes the necessity and importance of targeting LSCs in the treatment of hematopoietic malignancies.

This book focuses on advances in our understanding of the regulatory mechanisms of brain iron uptake, iron homeostasis and iron metabolism in the pathophysiology and pharmacology of CNS disease models.

The book elucidates the mechanism of assembly of these materials and characterisation of their mechanical and physico-chemical properties which inspires readers not only to exploit the potential applications of nanomaterials, but also to understand their potential risks and benefits.

This edited book explores the use of technology to enable us to visualise the life sciences in a more meaningful and engaging way. It will enable those interested in visualisation techniques to gain a better understanding of the applications that can be used in visualisation, imaging and analysis, education, engagement and training.The reader will be able to explore the utilisation of technologies from a number of fields to enable an engaging and meaningful visual representation of the biomedical sciences. This use of technology-enhanced learning will be of benefit for the learner, trainer and faculty, in patient care and the wider field of education and engagement.This second volume on Biomedical Visualisation will explore the use of a variety of visualisation techniques to enhance our understanding of how to visualise the body, its processes and apply it to a real world context. It is divided into three broad categories - Education; Craniofacial Anatomy and Applications and finally Visual Perception and Data Visualization.In the first four chapters, it provides a detailed account of the history of the development of 3D resources for visualisation. Following on from this will be three major case studies which examine a variety of educational perspectives in the creation of resources. One centres around neuropsychiatric education, one is based on gaming technology and its application in a university biology curriculum, and the last of these chapters examines how ultrasound can be used in the modern day anatomical curriculum.The next three chapters focus on a complex area of anatomy, and helps to create an engaging resource of materials focussed on craniofacial anatomy and applications. The first of these chapters examines how skulls can be digitised in the creation of an educational and training package, with excellent hints and tips. The second of these chapters has a real-world application related to forensic anatomy which examines skulls and soft tissue landmarks in the creation of a database for Cretan skulls, comparing it to international populations. The last three chapters present technical perspetives on visual perception and visualisation. By detailing visual perception, visual analytics and examination of multi-modal, multi-parametric data, these chapters help to understand the true scientific meaning of visualisation.The work presented here can be accessed by a wide range of users from faculty and students involved in the design and development of these processes, to those developing tools and techniques to enable visualisation in the sciences.

In this book, renowned scientists describe how cholesterol interacts with various proteins. In the second part of the book, examples of cholesterol binding sites and consequences of specific cholesterol recognition for protein function are presented for G protein-coupled receptors, ion channels and cholesterol-transporting proteins.

When taken as a whole, alongside its companion volumes Stem Cells Heterogeneity - Novel Concepts, and Stem Cells Heterogeneity in Different Organs, these three books present a comprehensive reference on stem cell heterogeneity in various tissues and current and future applications for regenerative medicine.

This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies' development and progression, and (2) the therapeutic strategies that are currently being explored to stop or delay disease progression. Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington's disease (HD); spinal-bulbar muscular atrophy (SBMA); and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17).The genetic basis of polyQ disorders is well established and described, and despite important advances that have opened up the possibility of generating genetic models of the disease, the mechanisms that cause neuronal degeneration are still largely unknown and there is currently no treatment available for these disorders. Further, it is believed that the different polyQ may share some mechanisms and pathways contributing to neurodegeneration and disease progression.

Part1 summarizes the ZIC family in animal evolution and development and presents an overall picture of the ZIC family gene structure in eumetazoan animals, providing an evolutionary hypothesis and reviewing the studies on the role of ZIC family proteins in developmental processes for each animal model.

This edited book explores the use of technology to enable us to visualise the life sciences in a more meaningful and engaging way. It will enable those interested in visualisation techniques to gain a better understanding of the applications that can be used in visualisation, imaging and analysis, education, engagement and training.The reader will be able to explore the utilisation of technologies from a number of fields to enable an engaging and meaningful visual representation of the biomedical sciences, with a focus in this volume related to anatomy, and clinically applied scenarios.The first six chapters have an anatomical focus examining digital technologies and applications to enhance education. The first examines the history and development of ultrasound, applications in an educational setting, and as a point-of-care ultrasound at the bedside. The second chapter presents a transferable workflow methodology in creating an interactive educational and training package to enhance understanding of the circadian rhythm. The third chapter reviews tools and technologies, which can be used to enhance off-campus learning, and the current range of visualisation technologies like virtual, augmented and mixed reality systems. Chapter four discusses how scanning methodologies like CT imagery, can make stereoscopic models. The fifth chapter describes a novel way to reconstruct 3D anatomy from imaging datasets and how to build statistical 3D shape models, described in a clinical context and applied to diagnostic disease scoring. The sixth chapter looks at interactive visualisations of atlases in the creation of a virtual resource, for providing next generation interfaces.The seventh and eight chapters discuss neurofeedback for mental health education and interactive visual data analysis (applied to irritable bowel disease) respectively.The final two chapters examine current immersive technologies ¿virtual and augmented reality, with the last chapter detailing virtual reality in patients with dementia.This book is accessible to a wide range of users from faculty and students, developers and computing experts, the wider public audience. It is hoped this will aid understanding of the variety of technologies which can be used to enhance understanding of clinical conditions using modern day methodologies.

This edited book is a compilation of findings on the molecular and cellular toxicity of nanoparticles (NPs) in animal cell, human cells, invertebrates.

The book is divided into eight parts, which respectively address: Taurine and Metabolism, Taurine and Nutrition, Taurine and Organ Dysfunction, Taurine and Heart Health, Taurine and Anti-cancer, Taurine and Anti-oxidation / Anti-microbial, Taurine and Neuroprotection, and Taurine and Anti-inflammatory.

The eukaryotic gene expression pathway involves a number of interlinked steps, with messenger RNA (mRNA) being the key intermediate. Although eukaryotic cells have evolved elaborate mRNA quality control mechanisms that ensure the fidelity of gene expression, some defects are not detected, thus affecting mRNA metabolism.

Numerous molecules participate in immune recognition, inhibition and activation, and these important immune molecules can be roughly divided into cell surface receptors, intracellular receptors and intracellular signaling molecules.

Hereditary tyrosinemia type 1 (HT1), the most severe inborn error of the tyrosine degradation pathway, is due to a deficiency in fumarylacetoacetate hydrolase (FAH).

The 2nd World Congress on Genetics, Geriatrics and Neurodegenerative Disease Research (GeNeDis 2016), will focus on recent advances in geriatrics and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments and will provide an international focum for the latest scientific discoveries, medical practices, and care initiatives. Advances information technologies will be discussed along with their implications for various research, implementation, and policy concerns. In addition, the conference will address European and global issues in the funding of long-term care and medico-social policies regarding elderly people.GeNeDis 2016 takes place in Sparta, Greece, 20-23 October, 2016. This volume focuses on thesessions that address neurodegenerative diseases.

Although much is known about the mechanisms that maintain genome integrity, little is known about the applications of this knowledge to combat human disease.

Finally the volume covers the examination of the potential mechanisms involved in controlling periconception period. From the early days of discovery about the basics of the fertilization process, scientists have known that early events happening during conception play a major part in the creation of new offspring.

A comprehensive overview of the many factors that can influence brain plasticity throughout the lifespan. Addresses perinatal plasticity, functional state plasticity, injury-induced plasticity, and stressor-induced plasticity.

The main goal of this book is to form a high-quality platform in which well-known and emerging pioneering basic, translational and clinical scientists can present their latest, exciting findings in the studies of redox signaling in the pulmonary vasculature.

This book presents descriptive overviews of gene editing strategies across multiple species while also offering in-depth insight on complex cases of application in the field of tissue engineering and regenerative medicine.

This is the first book compiling current research on the gut-bone signaling axis and its implications in the pathophysiology of GI and bone diseases.