This book gathers multidisciplinary articles that present advances of our understanding of diseases and the effective treatment of patients. The authors share recent clinical and experimental research findings, highlighting poorly understood areas with uncertain treatment outcomes, such as giant-cell bone tumors and their propensity to metastasize to the lungs; subterranean rehabilitation in pulmonary disorders; male reproductive hormone regulation during physical exercise in hyperbaric, hyperoxic environments, like underwater diving; and amelioration of cognitive decline owing to increased cerebral blood transit time after internal carotid artery stenting. Other topics include new concepts and innovations in the treatment of diabetes in pregnancy, and leg ulcers in chronic venous insufficiency, as well as molecular research on the toxic effects of oxidative stress, impaired cell autophagy, and experimental conditions resembling air pollution.Featuring the latest interdisciplinary advances in biomedicine, this book is a valuable resource for medical professionals, both academics and practitioners, and all allied health-care workers.
This book provides a comprehensive view of metabolomics, from the basic concepts, through sample preparation and analytical methodologies, to data interpretation and applications in medicine.
This book contains the refereed contributions from the 43rd annual meeting of ISOTT. The annual meetings of ISOTT bring together scientists from various fields (medicine, physiology, mathematics, biology, chemistry, physics, engineering, etc.) in a unique international forum.
This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing.
Due to continuous technical developments and new insights into the high complexity of neurological diseases, there is an increasing need for the application of proteomic technologies which can yield potential biomarker readouts for improved clinical management as well as for the development of new drugs by struggling pharmaceutical companies.
The aim of the Protein Reviews is to serve as a publication vehicle for review articles that focus on crucial current vigorous aspects of protein structure, function, evolution and genetics. The volumes will appear online before they are published in a printed book. Articles are selected according to their importance to the understanding of biological systems, their relevance to the unravelling of issues associated with health and disease or their impact on scientific or technological advances and developments. The chapters in volume 18 are authored by experts in the field. They deal with aspects of structure and/or biological activity of selected proteins. The chapters review current research of the following topics: the Mechanism of channel gating and regulation of the activity of calcium-activated chloride channel ANO1, Structure and function of the two-component cytotoxins of Staphylococcus aureus, Membrane Fusion and Infection involving the influenza virus hemagglutinin, The impact of arrhythmogenic mutations through the structural determination of the L-type voltage-gated calcium channel, Discussion of some open questions pertaining to histone post-translational modifications and nucleosome organization in transcriptional regulation, Regulation of the extracellular SERPINA5 (protein C inhibitor) penetration through cellular membranes, Coding of Class I and II aminoacyl-tRNA synthetases, Nephrin phosphorylation in diabetes and chronic kidney injury, The structure-forming juncture in oxidative protein folding and the events in the ER, The polyspecificity of anti-lipid antibodies and its relevance to the development of autoimmunity. This volume is intended for research scientists, clinicians, physicians and graduate students in the fields of biochemistry, cell biology, molecular biology, immunology and genetics.
This book summarizes the latest advances in pain research. All the chapters were contributed by speakers from Asian Pain Symposium (APS) on Acute and Chronic Pain, which was held in Taipei in 2017.
The companion title, Cell & Molecular Biology of Prostate Cancer, covers classic and modern cell and molecular biology as well as genetics, epigenetics, mitochondrial dysfunctions and apoptosis, cancer stem cells, angiogenesis, progression to metastasis, and treatment strategies including clinical trials related to prostate cancer.
Following the Third Alcohol and Cancer Conference, this volume compiles the most up-to-date research on the role of alcohol consumption in carcinogenesis, from epidemiology to pathology metabolism and stem cells.
This book covers the new Omics area, Metallomics. As Metallomics is intrinsically a transdisciplinary area, this book is authored by experts in the field on such diverse topics as Environmental, Nuclear, and Human Metallomics. Within these topics metals play important role, as being part of biomolecules, controlling different biochemical process, being signaling agents, being catalyst of biochemical reactions, among others. This volume demonstrates the importance of more investigation about metals and their interactions with biomolecules. As the knowledge in this field is growing and growing daily, then new challenges concerning studies involving Metallomics is appearing, such as comparative metallomics, speciation metallomics, real-time metallomics, new predictions of metals in biomolecules, metalloprotein databank expansion, interactions between metalloprotein-metalloprotein, among others.
Section two, Preclinical and Translational Science, will discuss cardiac ECM technologies in the clinical pipeline including approaches to ECM as a therapeutic, animal models of cardiac research, tracking and imaging methods of cardiac ECM, and cGMP manufacturing and regulatory considerations for ECM based therapeutics.
Clinical investigation plays an essential role in the differential diagnosis, biomarker development, and therapy and cure of diseases. The book presents a bench-to-bed approach, with broad empirical coverage by experienced practitioners. The articles include topics like cytokine receptors in lung cancer, conduciveness of oxidative stress to carcinogenesis, safety and effectiveness of surgical correction of deformed chest, diagnostic and treatment regimens in inflammation-ridden obstructive lung conditions, alterations in growth hormone secretion leading to disorders of growth and metabolism, microbiota transplantation in pediatric patients, and the promising markers of renal epithelial injury. Yet another issue concerns the restructuring of chronic pain management by establishing the community-based specialized pain clinics. The book aims to disseminate and deliberate on the latest interdisciplinary medical knowledge to enhance clinical outcomes. Being a blend of clinical investigation and practice the book is addressed to physicians, scientists, and allied health care professionals.
Using both epidemiological and model organism approaches, we have gained new insights into the physiological and molecular aspects of aging, which has led to significant advancements in potential anti-aging strategies.
This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy.
Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions.This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature¿s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the sixth volume of a continuing series.
This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease.
This book provides a comprehensive overview of the latest research on the molecular players in the tumor microenvironment, including Cathepsin D, galectins, iron, oxygen, Phospholipase D1, leptin, extracellular vesicles, and more.
Amy Zarzeczny The future of stem cell research and its clinical translation in Canada: Exploring questions of governance and policy options. Ali Mobasheri Future cell and gene therapy for osteoarthritis (OA): potential for using mammalian protein production platforms, irradiated and transfected protein packaging cell lines for over-production of therapeutic proteins and growth factors Babak Arjmand Bagher Larijani Motahareh Sheikh Hosseini Moloud Payab Kambiz Gilany Parisa Goodarzi Peyvand Parhizkar Roudsari Mobina Amanollahi Baharvand; Negin sadat Hoseini Mohammadi The Horizon of Gene Therapy in Modern Medicine: Advances and Challenges. Neslihan Meric, Gulen Guney Esken, Fatih Kocabas Developments in Artificial Platelet and Erythroid Transfusion Products. Ali Golchin, Forough Shams, Farshid Karami Advancing mesenchymal stem cell therapy with CRISPR/Cas9 for clinical trial studies. Tunc AKKOC Mesenchymal Stem Cells in Asthma. Toka A. Ahmed, Sara M. Ahmed, Zaynab El-Gammal,Shaimaa Shouman, Ashrakat Ahmed, Ragaa Mansour, and Nagwa El-Badri Oocyte Aging: the Role of Cellular and Environmental Factors and Impact on Female Fertility. Esra Aydemir Çoban, Didem Tecimel, Fikrettin Şahin, Ayşen Aslı Hızlı Deniz Targeting Cancer Metabolism and Cell Cycle by Plant-derived Compounds. Safa AYDIN, Derya SAĞRAÇ, Fikrettin ŞAHİN DIFFERENTIATION POTENTIAL OF MESENCHYMAL STEM CELLS INTO PANCREATIC β-CELLS. Ezgi Avşar Abdik, Ayşen Aslı Hızlı Deniz, Hüseyin Abdik, Safa Aydın, Fikrettin Şahin, Pakize Neslihan Taşlı Zooming in across the Skin: A Macro-to-Molecular Panorama.
In collaboration with the Breast Cancer Research Foundation (BCRF), this timely volume provides a comprehensive review on all areas of breast cancer survivorship research, highlighting research that is underway or in development.
The book discusses new concepts and findings in the field of pulmonary function. Pulmonary function goes far beyond spirometry. Chapters contribute to the latest thinking on molecular mechanisms underpinning pulmonary function, on patient care and attempt to keep up-to-date with current clinical and research progress.
The chapters of this book deal with the preventable drivers of poor respiratory health, the role of health information technology, the improvement in health care delivery and the integration of respiratory health and behavioral health services.
This unique publication explores diverse themes relating to thrombosis and embolism, from basic research at cell and molecular level to the actual care, prevention, and treatment of diverse categories of patients suffering from such diseases.
Nearly 30 years ago, a number of scientists working on the Enteric Nervous System (ENS) gathered at Flinders University, in Adelaide, Australia to discuss the advances and future of their research. It was a friendly and stimulating meeting, attended by most of the major players, in what was to become the discipline of ΓÇÿNeurogastroenterology''.In 2014, the main Australasian Neuroscience Society meeting was held in Adelaide, Australia, providing the perfect opportunity to recreate a follow-up ENS meeting. As such, the ΓÇÿENS II 2014 meetingΓÇÖ aimed to identify how far the field of enteric neuroscience had developed, where the future was heading, and what technological advances had been made to address current and future unresolved questions. 30 speakers from around the world were invited to give talks and revisit the original expectations, the advances made since, and the future directions of ENS research. These discussions included three generations of investigators from 7 different countries. This publication represents the majority of proceedings from the ΓÇÿThe Enteric Nervous System II 2014ΓÇÖ conference, which was held on February 1st - 2nd 2014 at the National Wine Centre of Australia, Adelaide. This meeting was an Official satellite meeting of the 34th Annual Meeting of Australasian Neuroscience Society, which was also held in Adelaide. The 20 contributions contained within this submission are from international researchers in the field of the ENS, who reviewed the advances made since the first meeting in the early 1980s and summarizes the present and future perspectives of neuro-gastroenterology. Some colleagues could not attend but did send greetings and their messages are included in these proceedings.
This Series will provide microbiologists, hygienists, epidemiologists and infectious diseases specialists with well-chosen contributed volumes containing updated information in the areas of basic and applied microbiology involving relevant issues for public health, including bacterial, fungal and parasitic infections, zoonoses and anthropozoonoses, environmental and food microbiology.The increasing threat of the multidrug-resistant microorganisms and the related host immune response, the new strategies for the treatment of biofilm-based, acute and chronic microbial infections, as well as the development of new vaccines and more efficacious antimicrobial drugs to prevent and treat human and animal infections will be also reviewed in this series in the light of the most recent achievements in these fields.Special attention will be devoted to the fast diffusion worldwide of the new findings of the most advanced translational researches carried out in the different fields of microbiological sciences, with the aim to promote a prompt validation and transfer at clinical level of the most promising experimental results.
Good health and medical care in childhood and adolescence are essential for the ability to neutralize health threats later in life and to extend longevity.
Lung ventilation is driven by a complex neural regulatory network, and apart from conditions typically observed during a disease state, it is sensitive to functional dysregulation.
The Advances in Microbiology, Infectious Diseases and Public Health Series will provide microbiologists, hygienists, epidemiologists and infectious diseases specialists with well-chosen contributed volumes containing updated information in the areas of basic and applied microbiology involving relevant issues for public health, including bacterial, fungal and parasitic infections, zoonoses and anthropozoonoses, environmental and food microbiology.The increasing threat of the multidrug-resistant microorganisms and the related host immune response, the new strategies for the treatment of biofilm-based, acute and chronic microbial infections, as well as the development of new vaccines and more efficacious antimicrobial drugs to prevent and treat human and animal infections will be also reviewed in this series in the light of the most recent achievements in these fields.Special attention will be devoted to the fast diffusion worldwide of the new findings of the most advanced translational researches carried out in the different fields of microbiological sciences, with the aim to promote a prompt validation and transfer at clinical level of the most promising experimental results.
This book centers on gene therapy and gene transfer approaches to prevent or treat chronic virus infections. Gene therapy applications for virus infections have been discussed since the early 1990's.
The chapters in this topical volume of Advances in Microbiology, Infectious Diseases and Public Health present exciting, insightful observations on emerging viral infections like influenza, Middle East respiratory syndrome, or mosquito-transmitted diseases, as well as the potential of social media in preventing and fighting infectious diseases.
Diseases of the respiratory system often cause multisystem dysfunction and morbidity.
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