Bücher der Reihe Advances in Experimental Medicine and Biology

Other issues pertain to quality of life, disease preventive measures, and the move toward personal health care in chronic sufferers from multiple conditions in later life. The book is addressed to researchers and practitioners, and allied health care professionals engaged in effective patient care and therapy.

Pulmonary diseases are the major cause of human morbidity, taxing the health care system due to disease prevalence, chronicity, and social and fiscal costs. Inflammation also is an essential component of non-communicable lung diseases, including asthma and respiratory allergies, and smoking-related or granulomatous diseases.

The book recognizes that throughout the scientific, medical, and economic communities, new tests incorporating biomarkers are needed to improve the diagnosis of patients suffering from metabolic disorders.

Each volume brings together some of the most pre-eminent scientists working on cancer biology, cancer treatment, cancer diagnosis, cancer prevention and regenerative medicine to share information on currently ongoing work which will help shape future therapies.

This book focuses on recent advances regarding clinical conditions and ailments whose mechanisms remain unclear, limiting our ability to treat them.The respective chapters address a range of multidisciplinary topics related to timely or emergent research areas, such as osteoporosis in postmenopausal women, the optimal surgical procedures for vertebral compression fractures, novel rehabilitative approaches in pelvic muscle training in case of urinary incontinence, and a rational approach to balneotherapy not only for the skin but also other organ systems disorders. Alterations in the endocrine function during strenuous physical activity at high altitude ¿ a multi-stressor environment comprising hypobaric hypoxia, exercise, and nutritional changes ¿ are presented as well. Other articles provide evidence-based insights into the diagnosis, mechanisms, and clinical course of respiratory infections in children such as bronchiolitis, pneumonia, and influenza. Finally, the pros and cons of e-health are discussed; a rapidly growing area based on the use of information and communication technology to streamline the flow of health information and patient-healthcare provider connections.The content is a well-structured blend of research and practical aspects, as well as updates on cutting-edge developments. All these essential topics are presented in a format suitable for medical professionals engaged in day-to-day patient care and therapy, as well as researchers, academics, and physiotherapists.

This book addresses several burning issues concerning diseases involving the lungs and respiratory tract. It discusses the epidemiology, mechanisms, prevention, and diagnosis of chest conditions such as chronic obstructive pulmonary disease, sleep apnea and respiratory infections.

Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components of the tumor during cancer development.

In turn, this will lead to new therapeutic strategies as well as drug development projects by the pharmaceutical industry.This book presents a series of reviews describing studies that have resulted in identification of new potential drug targets for age-related disorders.

A variety of topics are covered, including metabolism in the tumor microenvironment, stellate cells and endothelial progenitors in the tumor microenvironment, as well as the effects of HIV, viral hepatitis, and inflammation in the tumor microenvironment, and more.

This book shares the experimental findings and views in current multidisciplinary medical science combining both basic and applied research aimed at resolving problematic health issues.

The book's goal is to promote the restoration and maintenance of good health, disease prophylaxis, and improved patient management by integrating research into clinical work and findings on improving care.

Presents a discussion of the biological effects produced following the metabolism of xenobiotic chemicals to chemically reactive metabolites. This volume covers structure-activity relationships, advances in the chemistry of reactive metabolites, and the generation and activity of reactive oxygen species with special emphasis on nitric oxide.

During the past decade a significant international research effort has been directed towards understanding the composition and regulation of the preocular tear film.

The aim of the Protein Reviews is to serve as a publication vehicle for review articles that focus on crucial current vigorous aspects of protein structure, function, evolution and genetics. Volume 17 of Protein Reviews is the beginning of a new publication format. The volumes will appear online before they are published in a printed book. Articles will be selected according to their importance to the understanding of biological systems, their relevance to the unravelling of issues associated with health and disease or their impact on scientific or technological advances and developments. The chapters in this volume are authored by experts in the field. They deal with aspects of structure and biological activity of selected proteins. Specific chapters deal with the aggregation of FET proteins (FUS, EWSR1, TAF15) as a pathological change in amyotrophic lateral sclerosis, structural changes fundamental to gating of the cystic fibrosis transmembrane conductance regulator anion channel pore, the dual roles for epithelial splicing regulatory proteins 1 (ESRP1) and 2 (ESRP2) in cancer progression, controlling autolysis during flagella insertion in Gram-negative bacteria, the regulation of skeletal muscle myoblast differentiation and the proliferation by pannexins, hyaluronidase and chondroitinase, factors that control mitotic spindle elongation, how secreted phospholipase A2 type IIA (sPLA2-IIA) activates integrins in an allosteric manner, the simple and unique allosteric machinery of Thermus caldophilus lactate dehydrogenase, and the reduction of chemically stable multibonds: Nitrogenase-like biosynthesis of tetrapyrroles. This volume is intended for research scientists, clinicians, physicians, and graduate students in fields of biochemistry, cell biology, molecular biology microbiology, immunology and genetics.

Population-based clinical, epidemiological, and multicenter investigations are presented to provide a comprehensive update on prevalent respiratory problems; Chapters are relevant to the broad readership as they examine health care quality, effectiveness of therapeutic strategies, the patient quality of life, and other relevant health issues.

This new edition highlights the numerous advances made in the field of microbial endocrinology over the last five years. With new chapters on the microbiome and its relation to neurochemicals, this new edition brings this important volume up to date.

It often targets the respiratory tract and entwines with respiratory ailments, which makes it difficult to discern the cause-effect linkage. Chapters give insight into the innovations concerning modern pulmonary function tests, discuss pharmacological paradigms, and tackle the overlapping infectious aspects and clinical symptoms and markers.

This book consists of 3 volumes: Basic Science (Volume 1), Clinical Science (Volume 2) and Technology and Methodology (Volume 3).

This book is a collection of articles written by prominent scientists who gathered in the city of Recife, Brazil, 23-27 October 2010, celebrating the 10th International Symposium on Yersinia.

This collection of contributions on the subject of the neural mechanisms of sensorimotor control resulted from a conference held in Cairns, Australia, September 3-6, 2001. It was also decided to assign a whole section to muscle mechanics, a subject that is often left out altogether from conferences on motor control.

Following on the Aegean Conference on Complement Therapeutics, this book offers expert focus on contemporary and emerging aspects of complement-mediated disease pathogenesis and the development of therapeutics that modulate this system in a beneficial manner.

Today we can diagnose abnormalities in ten thousand genes and within a short period of time we will be able to screen through our genome and discover potential abnormalities in our proto-oncogenes, tumour suppressor genes, differentiating genes, apoptotic genes and pro-inflammatory genes.

This book represents the proceedings from a conference that took place in Dallas in the spring of 1999 which was entitled "Pediatric Gender Assignment - A Critical Reappraisal".

Quality is a composite term encompassing many characteristics of foods. Obviously deterioration of quality may lead to changes in the attributes that characterize the food in its fresh or freshly processed state. In this book, a cursory account of quality attributes of fresh and processed foods is provided.

The International Hypoxia Symposium convenes biannually to bring together international experts from many fields to explore the state of the art in normal and pathophysiological responses to hypoxia.

Given the very limited capacity of regeneration in the brain, protecting neurons that are on the brink of death is a major challenge for basic and clinical neuroscience, with implications for a broad spectrum of acute and chronic neurological and psychiatric diseases.

The quality of infant feeding is of major importance for child health development and well being, and breast feeding is the natural form of supplying food to the infant. This book includes proceedings of the 9th International Conference of the International Society for Research in Human Milk and Lactation (ISRHML).

Marks the culmination of research on the transplantation of dopaminergic neurons in the striatum of the weaver mouse, a neurological mutant characterized by genetically-determined degeneration of midbrain dopamine neurons. This book reviews structural and functional aspects of intrastriatal mesencephalic neuron grafting into the weaver model.

This volume is ideal for individuals interested in taking an in-depth look at how cytokines and chemokines participate in autoimmune disorders, and how cytokines and chemokines can be used as targets for therapeutic intervention.

The sections of the book focus on various topics: - Structure and function of dipeptidyl aminopeptidases, - DPP IV-like proteins, - Immune mechanisms and immune disorders, - Cancer and angiogenesis, - Diabetes and metabolism, - Therapeutic implications.