Bücher der Reihe Basic Life Sciences

Chromosomes, being well-defined structures that are easily vis ible under the optical microscope, readily lend themselves to in tense physical and biochemical study. One of the most important stages in chromosome research was the development, in radiation biology, of radiolabeling the chromosome with tritiated thymidine.

The Symposium on Organ and Species Specificity in Chemical Carcinogenesis was held March 1981 in Raleigh, North Carolina. We badly need an adequate data base on human organs, human tissues, human cells, human subcellular preparations, and human body fluids.

Omenn Dean, School of Public Health and Community Medicine University of Washington Seattle, Washington 98195 On behalf of the University of Washington , the City of Seattle, the Steering Committee, and the sponsoring agencies, corporations, and organ izations, I welcome you.

Such processes repre sent one natural mechanism by which Man can augment soil N for agronomic purposes without using fossil fuel to synthesize and distribute N fertilizer. Thus nitrification, denitrification, and utilization of soil N by plants are processes that must be con sidered if one is to conserve N captured by N2 fixation.

It has been nearly 35 years since the peacetime Biology Division of Oak Ridge National Laboratory was started, born of rather inauspicious conditions. Although good biological work had been done at Oak Ridge during the war to protect the workers and the results of this work were quite excellent, very few installations remained.

This book is concerned with the genetic consequences of nu cleotide pool imbalance. This book grew out of a Conference on "Genetic Consequences of Nu cleotide Pool Imbalance" which was held at the National Institute of Environmental Health Sciences on May 9-11, 1983.

The program was chosen to explore what is currently known about the underlying causes, the origins, and the extent of the prob lem of human aneuploidy, and whether exposure to environmental agents is assodated with an increased incidence of aneuploidy in humans.

The analysis of intra-group correlations between LS and BW at representative intervals yields no consistent support for the hypothesis that lower BW is associated with longer LS. However, when BW at absolute ages were correlated with LS, support for the positive relationship between BW and LS was not as forthcoming.

Based on a conference held in Cleveland, Ohio, September 28--30, 1988

Proceedings based on an American Chemical Society symposium held in Los Angeles, California, September 25--28, 1988, and an ACS symposium held in Toronto, Canada, June 5--8, 1988

Proceedings of an International Workshop held at the Massachusetts Institute of Technology, in Cambridge, Massachusetts, March 29-31, 1989

How far can we ignore human variability in risk assessment? The aim of our meeting was to bring together experts from the fields of human epidemiology, toxicology, aging, genetics, carcino genesis and teratology, and to provide a forum in which we might assimi late knowledge of human heterogeneity as a coherent whole.

These are the same chemicals that are in use throughout the develop ing world, although the quantities of the different types that are used may vary from country to country, and from region to region within countries.

Omenn Dean, School of Public Health and Community Medicine University of Washington Seattle, Washington 98195 On behalf of the University of Washington , the City of Seattle, the Steering Committee, and the sponsoring agencies, corporations, and organ izations, I welcome you.

The Eleventh International Latin American Symposium is an important mile stone reflecting the rapid development of basic biochemistry in Latin America.

We knew that light was an important factor for cell recovery, so all our experiments were done in dim light, with the plated-out cells being covered with dark cloth.

With the encouragement of members of the Ford Foundation staff and the National Academy of Sciences, the idea for a symposium on the broad approach to the problem of nutrition was developed by Dr. Moises Behar, the second director of INCAP, 1961-1974, Dr. Nevin Scrimshaw, fIrst director of INCAP, 1949-1961, and members of the INCAP staff.

The present volume includes the large majority of papers given at the symposium entitled "Fundamental Approaches to Plant and Animal Improvement," held at Cali, Colombia, in November, 1972.

The approach used in this Symposium together with the one held four months earlier in Brookhaven on ;'Genetic Engineering for Nitrogen Fixation" gives an interesting picture of the present status of nitrogen fixation from two diverse approaches.

Our present concepts ofthe regulation of enzyme activity in the cell have been largely based on the extensive body of work which has been carried out with micro-organisms.

This 1988 special workshop, interspersed between the biannual international symposia, represents an effort to seek ideas and advice on the clinical a~pects of BNCT, from all those diverse groups with a national commitment to this project.

Even though most of our understand ing about the factors that contribute to a successful tagging experiment has been accumulated from a limited number of experiments using different transposable elements in different genetic backgrounds, it is still possible to draw some conclusions regarding the best experimental strategies for gene tagging.

Not many years ago most discussion of mutation induction by physical and chemical agents concentrated on the initial lesions induced in the DNA with the implicit assumption that once the lesions were made they were converted almost automatically to mutations by relatively simple processes associated with DNA replication.