Bücher der Reihe Biological and Medical Physics, Biomedical Engineering

Intended for undergraduate courses in biophysics, biological physics, physiology, medical physics, and biomedical engineering, this is an introduction to statistical physics with examples and problems from the medical and biological sciences.

Escherichia coli, commonly referred to as E. Scientists and engineers, not trained in microbiology, and who would like to learn more about living machines, can see it as a unique example. This cross-disciplinary monograph covers more than thirty years of research and is accessible to graduate students and scientists alike.

In addition to surveying the latest developments in our understanding of the respiratory system, this book on a topic boosted by recent advances in imaging and computational fluid dynamics disentangles the complexities and includes guidelines on best practice.

This book covering the basics and the state-of-the-art of cryobiology and its applications emphasizes the underlying physical phenomena. It includes a comprehensive glossary and appendices for deeper exploration into special issues.

This book demonstrates the applications of synchrotron radiation in certain aspects of cell microbiology, specifically non-destructive elemental analyses, chemical-state analyses and imaging (distribution) of the elements within a cell.

As well as its didactic presentation of the field, this volume covers the commercial applications of biomimetics, detailing all of the most important effects and covering a number of examples including roughness-induced superomniphobic surfaces.

Membrane Biophysics is tailored for readers who want to understand biological processes by applying both simple observations and scientific analysis. The text explores the causes and effects of membrane processes, and will eventually open new doors for pharmaceutical approaches to related diseases.

A reissue of a classic book, intended for undergraduate courses in biophysics, biological physics, physiology, medical physics, and biomedical engineering. The book can be used as a supplement to standard introductory physics courses, as well as for medical schools, medical physics courses, and biology departments.

This book introduces and reviews all of the currently available methods being used for computational electroencephalogram (EEG) analysis, from the fundamentals through to the state-of-the-art. The aim of the book is to help biomedical engineers and medical doctors who use EEG to better understand the methods and applications of computational EEG analysis from a single, well-organized resource.Following a brief introduction to the principles of EEG and acquisition techniques, the book is divided into two main sections. The first of these covers analysis methods, beginning with preprocessing, and then describing EEG spectral analysis, event-related potential analysis, source imaging and multimodal neuroimaging, and functional connectivity analysis. The following section covers application of EEG analysis to specific fields, including the diagnosis of psychiatric diseases and neurological disorders, brain-computer interfacing, and social neuroscience.Aimed at practicing medical specialists, engineers, researchers and advanced students, the book features contributions from world-renowned biomedical engineers working across a broad spectrum of computational EEG analysis techniques and EEG applications.

This book is the first to be entirely devoted to the challenging art of handling membrane proteins out of their natural environment, a key process in biological and pharmaceutical research, but one plagued with difficulties and pitfalls. Written by one of the foremost experts in the field, Membrane Proteins in Aqueous Solutions is accessible to any member of a membrane biology laboratory. After presenting the structure, functions, dynamics, synthesis, natural environment and lipid interactions of membrane proteins, the author discusses the principles of extracting them with detergents, the mechanisms of detergent-induced destabilization, countermeasures, and recent progress in developing detergents with weaker denaturing properties. Non-conventional alternatives to detergents, including bicelles, nanodiscs, amphipathic peptides, fluorinated surfactants and amphipols, are described, and their relative advantages and drawbacks are compared. The synthesis and solution properties of the various types of amphipols are presented, as well as the formation and properties of membrane protein/amphipol complexes and the transfer of amphipol-trapped proteins to detergents, nanodiscs, lipidic mesophases, or living cells. The final chapters of the book deal with applications: membrane protein in vitro folding and cell-free expression, solution studies, NMR, crystallography, electron microscopy, mass spectrometry, amphipol-mediated immobilization of membrane proteins, and biomedical applications.Important features of the book include introductory sections describing foundations as well as the state-of-the-art for each of the biophysical techniques discussed, and topical tables which organize a widely dispersed literature. Boxes and annexes throughout the book explain technical aspects, and twelve detailed experimental protocols, ranging from in vitro folding of membrane proteins to single-particle electron cryomicroscopy, have been contributed by and commented on by experienced users.Membrane Proteins in Aqueous Solutions offers a concise, accessible introduction to membrane protein biochemistry and biophysics, as well as comprehensive coverage of the properties and uses of conventional and non-conventional surfactants. It will be useful both in basic and applied research laboratories and as a teaching aid for students, instructors, researchers, and professionals within the field.

In addition to considering the problems of biomedical cell diagnostics, and modeling the scattering of laser irradiation of blood cells for biological structures (dermis, epidermis, vascular plexus), it presents an analytic theory based on solving the wave equation for the electromagnetic field.

This book begins with the basic terms and definitions and takes a student, step by step, through all areas of medical physics. Students will find An Introduction to Medical Physics to be an indispensible resource in preparations for further graduate studies in the field.

This book describes radionanomedicine as an integrated medicine using exogenous and endogenous This book describes radionanomedicine as an integrated approach that uses exogenous and endogenous nanomaterials for in vivo and human applications.

This book is devoted to the physical and mathematical modeling of the formation of complexes of protein molecules.

At last, the molecular identity of two important channels in the mitochondrial inner membrane, the mitochondrial calcium uniporter and the mitochondrial permeability transition pore have been established.

Aspects covered include the detection of injuries in sports medicine, the assessment of sports performance due to the existing link between physical fitness and thermoregulation and the analysis of heat transfer for sports garments and sports equipment.

This book deals with the new method of laser-driven acceleration for application to radiation biophysics and medicine. It provides multidisciplinary contributions from world leading scientist in order to assess the state of the art of innovative tools for radiation biology research and medical applications of ionizing radiation.

Microwave breast imaging is based on a contrast in the dielectric properties of breast tissue that exists at microwave frequencies. The book begins by considering the anatomy and dielectric properties of the breast, contrasting historical and recent studies.

This book presents the advances in super-resolution microscopy in physics and biomedical optics for nanoscale imaging.

This book addresses how proteins and RNA interact to carry out biological functions such as protein synthesis, regulation of gene expression, genome defense, liquid phase separation and more.The topics addressed in this volume will appeal to researchers in biophysics, biochemistry and structural biology.

This book surveys the most recent advances in physics-inspired cell movement models. This synergetic, cross-disciplinary effort to increase the fidelity of computational algorithms will lead to a better understanding of the complex biomechanics of cell movement, and stimulate progress in research on related active matter systems, from suspensions of bacteria and synthetic swimmers to cell tissues and cytoskeleton.Cell motility and collective motion are among the most important themes in biology and statistical physics of out-of-equilibrium systems, and crucial for morphogenesis, wound healing, and immune response in eukaryotic organisms. It is also relevant for the development of effective treatment strategies for diseases such as cancer, and for the design of bioactive surfaces for cell sorting and manipulation. Substrate-based cell motility is, however, a very complex process as regulatory pathways and physical force generation mechanisms are intertwined. To understand the interplay between adhesion, force generation and motility, an abundance of computational models have been proposed in recent years, from finite element to immerse interface methods and phase field approaches.This book is primarily written for physicists, mathematical biologists and biomedical engineers working in this rapidly expanding field, and can serve as supplementary reading for advanced graduate courses in biophysics and mathematical biology. The e-book incorporates experimental and computer animations illustrating various aspects of cell movement.

This book highlights important techniques for cellular imaging and covers the basics and applications of electron tomography and related techniques.

This new edition presents an authoritative account of the current state of brain biomechanics research for engineers, scientists and medical professionals. Since the first edition in 2011, this topic has unquestionably entered into the mainstream of biomechanical research. The book brings together leading scientists in the diverse fields of anatomy, neuroimaging, image-guided neurosurgery, brain injury, solid and fluid mechanics, mathematical modelling and computer simulation to paint an inclusive picture of the rapidly evolving field.Covering topics from brain anatomy and imaging to sophisticated methods of modeling brain injury and neurosurgery (including the most recent applications of biomechanics to treat epilepsy), to the cutting edge methods in analyzing cerebrospinal fluid and blood flow, this book is the comprehensive reference in the field. Experienced researchers as well as students will find this book useful.

This book updates and expands on various aspects of the vasculature¿s microenvironment and how these regulate differentiation and assembly. Discussed in this new edition are efforts to capitalize on combing engineering techniques, to study and manipulate various biophysical cues, including: endothelial cell- pericyte interactions (Davis), mechanical forces to regulate vascularization in three-dimensional constructs (Levenberg), how matrix properties and oxygen tension regulate vascular fate and assembly (Gerecht), biophysical cues in relation to vascular aging (Ferreira), 3D printing of complex vascularized tissue (Hibino), the harnessing of biophysical cues for therapeutic vasculature interfacing with the damaged brain (Segura) and finally, the infarcted heart (Grayson). This second edition of Biophysical Regulation of Vascular Differentiation and Assembly provides an interdisciplinary view of vasculature regulation thru various biophysical cues and presents recent advances in measuring and controlling such parameters. This book will be of interest to biologists, biophysicists and engineers who work with vascular differentiation and assembly.

In addition to considering the problems of biomedical cell diagnostics, and modeling the scattering of laser irradiation of blood cells for biological structures (dermis, epidermis, vascular plexus), it presents an analytic theory based on solving the wave equation for the electromagnetic field.

This book is devoted to the physical and mathematical modeling of the formation of complexes of protein molecules.

This book introduces the latest optical coherence tomography (OCT) imaging and computerized automatic image analysis techniques, and their applications in the diagnosis and treatment of retinal diseases. Discussing the basic principles and the clinical applications of OCT imaging, OCT image preprocessing, as well as the automatic detection and quantitative analysis of retinal anatomy and pathology, it includes a wealth of clinical OCT images, and state-of-the-art research that applies novel image processing, pattern recognition and machine learning methods to real clinical data. It is a valuable resource for researchers in both medical image processing and ophthalmic imaging.

This book introduces and reviews all of the currently available methods being used for computational electroencephalogram (EEG) analysis, from the fundamentals through to the state-of-the-art. The aim of the book is to help biomedical engineers and medical doctors who use EEG to better understand the methods and applications of computational EEG analysis from a single, well-organized resource.Following a brief introduction to the principles of EEG and acquisition techniques, the book is divided into two main sections. The first of these covers analysis methods, beginning with preprocessing, and then describing EEG spectral analysis, event-related potential analysis, source imaging and multimodal neuroimaging, and functional connectivity analysis. The following section covers application of EEG analysis to specific fields, including the diagnosis of psychiatric diseases and neurological disorders, brain-computer interfacing, and social neuroscience.Aimed at practicing medical specialists, engineers, researchers and advanced students, the book features contributions from world-renowned biomedical engineers working across a broad spectrum of computational EEG analysis techniques and EEG applications.

Electric biosignals are considered, starting with the biosignal formation path to biosignal propagation in the body and finally to the biosignal sensing path and the recording of the signal.

This book is the first to be entirely devoted to the challenging art of handling membrane proteins out of their natural environment, a key process in biological and pharmaceutical research, but one plagued with difficulties and pitfalls. Written by one of the foremost experts in the field, Membrane Proteins in Aqueous Solutions is accessible to any member of a membrane biology laboratory. After presenting the structure, functions, dynamics, synthesis, natural environment and lipid interactions of membrane proteins, the author discusses the principles of extracting them with detergents, the mechanisms of detergent-induced destabilization, countermeasures, and recent progress in developing detergents with weaker denaturing properties. Non-conventional alternatives to detergents, including bicelles, nanodiscs, amphipathic peptides, fluorinated surfactants and amphipols, are described, and their relative advantages and drawbacks are compared. The synthesis and solution properties of the various types of amphipols are presented, as well as the formation and properties of membrane protein/amphipol complexes and the transfer of amphipol-trapped proteins to detergents, nanodiscs, lipidic mesophases, or living cells. The final chapters of the book deal with applications: membrane protein in vitro folding and cell-free expression, solution studies, NMR, crystallography, electron microscopy, mass spectrometry, amphipol-mediated immobilization of membrane proteins, and biomedical applications.Important features of the book include introductory sections describing foundations as well as the state-of-the-art for each of the biophysical techniques discussed, and topical tables which organize a widely dispersed literature. Boxes and annexes throughout the book explain technical aspects, and twelve detailed experimental protocols, ranging from in vitro folding of membrane proteins to single-particle electron cryomicroscopy, have been contributed by and commented on by experienced users.Membrane Proteins in Aqueous Solutions offers a concise, accessible introduction to membrane protein biochemistry and biophysics, as well as comprehensive coverage of the properties and uses of conventional and non-conventional surfactants. It will be useful both in basic and applied research laboratories and as a teaching aid for students, instructors, researchers, and professionals within the field.