Bücher der Reihe Chromatographic Science Series

This important, new reference provides the first , up-to-date, and comprehensive treatmentof the various liquid chromatography (LC) instrumentation for Therapeutic DrugMonitoring (TDM) and toxicology drug assays and reviews the clinical pharmacologyof major classes of drugs and their LC analyses

Focusing on recent developments in microfluidic lab-on-a-chip technologies, this book offers an overview of the limitations and breakthroughs of this technology over the years. The author emphasizes analytical applications of microfluidic technology and offers in-depth coverage of micromachining methods, microfluidic operations, chemical separat

This book serves as a comprehensive source of information and training on the state-of-the-art pesticide residues methods performed with aid of HPLC and aids the readers in avoiding the many pitfalls that are possible during work with the HPLC mode

An up-to-date reference that presents the most important information about each area of chemometrics used in chromatography, demonstrating its effective use when applied to a chromatographic separation.

This book provides a comprehensive source of knowledge of new sorbent materials, presenting fundamental principles for their syntheses, and adsorption properties. It presents advanced techniques employed to create specialized sorbents with a wide range of functions, which can be used to enhance the separation and/or purification of useful bioact

Xenobiotics are chemical compounds foreign to a given biological system. This reference will help the analyst develop effective and validated analytical strategies for the analysis of hundreds of different xenobiotics on hundreds of different sample types, quickly, accurately and at acceptable cost.

An up-to-date reference that presents the most important information about each area of chemometrics used in chromatography, demonstrating its effective use when applied to a chromatographic separation.

This is the first book that comprehensively and systematically describes the new technology of hydrophilic interaction liquid chromatography (HILIC). Hydrophilic interaction chromatography is a separation technique suitable for polar and hydrophilic compounds and orthogonal to reversed phase liquid chromatography. From small organic molecules to proteins, the text explores the many applications of HILIC in the analytical field. Winner of the President''s Award for Excellence, the author explains how HILIC can significantly improve analytical throughput by shortening sample preparation procedure, which is one of the bottlenecks for drug discovery and development in the pharmaceutical industry.

This book focuses on a relatively new approach to chemical analysis in general, and to separation science in particular. It is the first book to systemically cover the theoretical background, techniques, instrumentation, and practical applications of planar chromatography ¿ mass spectrometry as a hyphenated tool of analytical chemistry. It also examines the high and as-yet unexploited potential of planar chromatography¿mass spectrometry for analytical use in scientific investigations and promotes its expanded use in academia and industry.

Discusses a model for the propagation of a finite concentration zone in a chromatographic column for the case of a single component sample, and explores operating conditions of ion-exchange chromatography for the production of albumin from bovine serum and plasma.

Presents practical information on the application of capillary electrophoresis (CE) to protein analysis, with an emphasis on developing and optimizing CE techniques in the laboratory. This title includes separation methods bases on mass, charge, isoelectric point, molecular sieving, and affinity interactions.

This is the first book that comprehensively and systematically describes the new technology of hydrophilic interaction liquid chromatography (HILIC). Hydrophilic interaction chromatography is a separation technique suitable for polar and hydrophilic compounds and orthogonal to reversed phase liquid chromatography. From small organic molecules to proteins, the text explores the many applications of HILIC in the analytical field. Winner of the President's Award for Excellence, the author explains how HILIC can significantly improve analytical throughput by shortening sample preparation procedure, which is one of the bottlenecks for drug discovery and development in the pharmaceutical industry.

This volume is the first book to give a complete description of the techniques, materials, and instrumentation of column HPLC and its application to essentially all primary and secondary plant metabolites. It describes the techniques and instrumentation of HPLC analysis, such as HPLC/nuclear magnetic resonance spectrometry, HPLC with photodiode array detection, and HPLC chiral analysis. It explores the application of HPLC to primary and secondary plant metabolites and discusses how HPLC is used for analyzing herbal drugs and dietary supplements.

This book provides a detailed description of technical elements of a microbore column liquid chromatograph suitable for use in trace analysis. It presents examples of analyses, especially from the spheres of biochemistry, pharmacology, and environmental analytical chemistry.

Considers three fundamental aspects of molecular interactions important in chromatography, taking care not to duplicate information readily available in other references. Surveys the basic factors involved in complex formation, which governs the retention mechanism and selectivity in either donor or

This book discusses flow perturbation method, namely, the stopped-flow technique and the reversed-flow technique. It is directed to those who need an accurate method for the determination of a certain physicochemical quantity and to researchers working on the development of gas chromatography.

Covering advancements in separation technique, this book presents concepts including monolithic columns, bonded stationary phases, micro-HPLC, two-dimensional comprehensive liquid chromatography, and capillary electromigration techniques. It covers areas of HPLC application, including chiral pharmaceutical, food, and forensic analysis.

This book gives the pertinent information on the high pressure liquid chromatography (HPLC) analyses of all the compounds of interest in nucleic acid metabolism. It aids chromatographers, biochemists, biomedical researchers, and chemists by giving information on applications of HPLC technique.

This book describes new gel permeation chromatography/liquid chromatography applications and techniques that will provide polymer scientists and practitioners with insight into the development of new polymers and plastics and improvement of existing materials.

This book describes the various aspects of microbore column chromatography. It provides readers with an in-depth understanding of the supercritical fluid chromatography and microbore high-performance liquid chromatography.

This book informs the reader about the practical methods, possibilities, and limits of template chromatography. It shows the various techniques for immobilization of nucleic acids fragments, polynucleotides, and nucleic acids by which the desired separation of materials can be achieved.

This book covers the principles, kinetics, and applications of derivatization reactions in liquid chromatography. It emphasizes detection-oriented derivatization procedures that can be used to enhance to detectability of a wide variety of solutes using absorbance and fluorescence detection.

This book summarizes all the important aspects of multidimensional separations, providing information on gas, liquid and thin-layer chromatography, as well as the techniques and applications of supercritical fluid chromatography in the multidimensional mode.

The first book to focus entirely on reactions for analyte detection and characterization,Reaction Detection in Liquid Chromatography depicts off- and on-line, pre- and postcolumnapproaches that have been successfully used for many classes of compounds, bothorganic and inorganic, in high performance liquid chromatography

This book documents the principles of operation, the advantages and drawbacks, and the potential future of currently available liquid chromatographic detectors. In offering a snapshot of the current technology, it provides clear explanations and possible new horizons for both beginners and experts.

This book covers a range of topics of interest to those involved in the fractionation and characterization of polymeric substances. It deals with problems that are encountered in modern gel permeation chromatography with dual detection when calculating average molecular weights.

Shows how to choose the most effective techniques for assessing the toxicity of chemicals in both food and the environment. This title examines a range of volatile compounds from toxic aldehydes and pesticides to micotoxins and dioxins.

Focuses on the various aspects of the microfluidic lab-on-a-chip technologies and offers an overview of the available technology, its limitations and its breakthroughs over the years. This work emphasizes analytical applications of microfluidic technology and offers coverage of micromachining methods, microfluidic operations and injection methods.

Explains to chromatographers that gas-liquid chromatography, a development of gas chromatography, is itself just a limited case of gas-liquid-solid chromatography.

Presenting a constructive evaluation of the most significant developments in liquid chromatography - mass spectrometry (LC-MS) and its uses for quantitative bioanalysis and characterization for a diverse range of disciplines, this title offers coverage of the technological developments and applications.