Bücher der Reihe Colloquium der Gesellschaft fur Biologische Chemie in Mosbach Baden

HERBERT FISCHER Max-Planck-Institut fur Immunbiologie, Freiburg-Zahringen With 3 Figures Ladies and Gentlemen: On behalf of the organizers of the 22nd Mosbach Colloquium, Msrs.

It has been known for a long time that such linkage occurs between the chromosomes of bacteriophages and plasmids on the one hand and the chromosome of the bacterial host on the other. A different kind of bacteriophage integration is shown by bacteriophage Mu, which is much less specific in its choice of an integration site than A.

In this volume are printed all the papers presented - with two regret ted exceptions - but not the sometimes lively discussion, which clari fied and pruned here and there.

Protein engineering has had considerable impact on basic and applied research in biochemistry and molecular biology. Protein engineering, perhaps more than any other methods of protein analysis and peptide synthesis, has shown that proteins are organic molecules governed by the universal laws of chemistry and physics.

Molecular biology has dissected the functional domains of the motor proteins involved and provided material required for biochemical studies as well as structure analysis by X-ray diffraction and NMR.

Provided here is an easily accessible introduction to themechanisms of DNA replication, regulation and thebiochemistry of cell cycle control.

The present volume contains 17 lectures of the 41 st Mosbach Colloquium of the Gesellschaft fiir Biologische Chemie, held from April 5-7, 1990 on the topic "The Molecular Basis of Bacterial Metabolism".

Recent years have seen tremendous progress in the field of hormone action and consequent signal transduction. The 40th Colloquium Mosbach was devoted to the discussion of results concerning the molecular process of hormone action, especially the processes following hormone binding to the corresponding receptors.

The avail ability of new genetic and immunological techniques, especially recom binant DNA methods and monoclonal antibody technology, has provided powerful tools for unravelling the genetic, biochemical and immunologi cal basis of viral and microbial pathogenesis.

This volume represents the proceedings of the 24th Mos bach Colloquium on "Regulation of Transcription and Trans lation in Eukaryotes" which was held April 26-28, 1973, in Mosbach, Germany, under the auspices of the Gesellschaft fiir Biologische Chemie.

It is two years since a general meeting of the Gesellschaft fur Biologische Chemie first requested us to organize the 21 st Mosbach Colloquium on mammalian reproduction, and one year since we received final authorization to do so.

Understanding the biological role of the diverse oligosaccharides of glycoproteins and glycolipids has been a major challenge in cell biology. Further, glycoproteins of the cell membrane play a major role in cell adhesion, hormone function, antibody action and signal mediation.

Enzymes perform the executive role in growth, energy conversion, and repair of a living organism. The physical ba sis of rate-enhancement is understood in principle and further exploit ed in the design of small organic receptor molecules as model enzymes. Session 2 emphasizes the dynamic aspects of enzyme substrate inter action.

Eukaryotic cells contain a plurality of organelles distinguished by their specific membranes and contents. The assembly of prokaryotic membranes and the membrane of an animal virus were also discussed, since these simpler systems might shed light on the biogenesis of organelles in eukaryotes.

The cells of the immune system generate a large variety of binding sites which differ in their binding specificities and can therefore react specifically with a large variety of ligands. the binding of antigen and possible reactions occurring in the antibody molecule upon antigen binding.

The scope of the 20th Mosbach Colloquium may be best illustrated by the following notes sent to the speakers when the colloquium was organized. 2) At this colloquium we want to contribute illustrations of the useful application of inhibitors to biological problems.

The 35th N:osbach Colloquium "The Impact of Gene Transfer Techniques in Eukaryotic CeU Biology" brought together a number of speakers interested in various aspects of cellular and developmental biology and over 600 other scientists, who listened to the lectures and participated in the lively discussions.