Bücher der Reihe Colloquium Series on Integrated Systems Physiology: From Molecule to Function to Disease

Reviews the essential role of the lateral hypothalamic area (LHA) for the control of body weight, from its historical description as a "feeding centre" to the current view of this LHA as a cellularly heterogeneous hub that regulates multiple aspects of physiology to influence body weight. The authors also evaluate how specific LHA populations coordinate certain metabolic cues and behaviours.

Proper vascular development in the placenta is fundamental to ensuring a healthy fetus and successful pregnancy. This book provides an up-to-date summary and synthesis of knowledge regarding placental vascular biology and discusses the relevance of this vascular bed to the functions of the human placenta.

Provides medical and graduate students, medical and surgical residents, and subspecialty fellows a comprehensive summary of digestive system physiology and addresses the pathophysiological processes that underlie some GI diseases. The textual approach proceeds by organ, allowing the reader to track the food bolus through the GI tract.

Provides an overview of the history of the discovery (and re-discovery) of the components of the lymphatic system, lymphatic anatomy, physiological functions of lymphatics, molecular features of the lymphatic system, and clinical perspectives involving lymphatics which may be of interest to scientists, clinicians, patients, and the public.

Pulmonary hypertension is a life-threatening disease with no known cure. This volume provides a concise yet comprehensive review of the current knowledge about the pathophysiology of pulmonary hypertension (PH). The underlying signaling mechanisms involved in pulmonary vascular remodeling and the exaggerated vascular contractility are discussed in depth.

Focuses on the structural, biochemical, and diverse functional properties of the endothelial luminal membrane glycocalyx, an organelle which constitutes the endothelial cell "membrane". This volume provides the newcomer with a broad, basic, and brief perspective of the luminal endothelial vascular membrane, and for the more established investigator, a basic overview and integrated perspective.

Discusses the sympathetic neural response to heat stress, how the sympathetic nervous system coordinates the successful integrative physiological response to orthostasis, and what happens when it encounters both challenges simultaneously. The book includes overviews of mechanisms of thermoregulation and blood pressure regulation in humans.

The kidney is innervated with efferent sympathetic nerve fibres reaching the renal vasculature, the tubules, the juxtaglomerular granular cells, and the renal pelvic wall. The renal sensory nerves are mainly found in the renal pelvic wall. The volume discusses neural control of renal function.