Bücher der Reihe Colloquium Series on Protein Activation and Cancer

Provides an overview of angiogenesis processes and discusses the importance of VEGF-C and VEGF-D precursors processing by the proprotein convertases during the activation of VEGFR-2 and VEGFR-3 receptors and the mediation of their functions during angiogenesis, lymphangiogenesis, and tumorigenesis.

Provides an overall review of all non-peptide PCSK inhibitors so far reported in the literature along with those identified recently for the first time and not yet published. The potential implications of these molecules as biochemical, therapeutical, or clinical agents is also discussed.

Proprotein convertases (PCs) are a family of proteases including PC1, PC2, Furin, PC4, PACE4, PC5, and PC7. This title discusses a number of previous and recent findings on the PCs features, their implication in the regulation of multiple cellular functions that impact on the invasive/metastatic potential of cancer cells, and their clinical relevance in cancer patients.