Bücher der Reihe Contemporary Neuroscience

The idea for this book has evolved from our desire to present a conceptual approach to the study of neurotransmitters in epilepsy.

One volume in a two-part series, covering the physiological and metabolic interactions between neurons and glia across the phylogenetic groups. New insights into neuron-glia relationships result from this comparative approach.

This part of the brain has been of continuing interest to me, from my days as a postgraduate student in the mid-1960s to the present time, because so many ideas about central auditory organization and function have developed from studies of this region.

More recently I have developed a rather more specific interest in the role of zinc, particularly in relation to the dominance of zinc metalloenzymes in the processes of DNA replication and repair, and its possible significance for human pathology.

Recent evidence, however, suggests that channels, pumps, and ionic exchangers are involved in CNS ischemia and ischemic stroke, but the potential contribution of these channels for curing stroke is far less understood than for many other normal and pathological conditions.

Prominent experimentalists critically review the animal models widely used in developing powerful new therapies for central nervous system diseases.

Distinguished researchers review the latest scientific understanding of spinal cord injury (SCI), focusing on the mechanisms causing paralysis after spinal cord trauma, the molecular determinants of neural regeneration, and methods for improving damaged function.

In Neuroprotective Signal Transduction prominent researchers and clinicians focus on how inter- and intracellular signaling mechanisms prevent the degeneration and death of neurons occurring in both acute and chronic neurodegenerative disorders.

In this book, leading-edge investigators offer effective strategies to improve current antidepressive therapies and suggest molecular, biological, and genetic approaches that will lead to the development of novel antidepressants.

This text covers such topics as: somatotopic organization of the striatum and its relevance to neural transplantation; evaluation of patients with Parkinson's disease; the Lund Transplant Program (Parkinson's disease and MPTP patients); and the Paris Program.

One volume in a two-part series, covering the physiological and metabolic interactions between neurons and glia across the phylogenetic groups. New insights into neuron-glia relationships result from this comparative approach.

Neurotherapeutics: Emerging Strategies reflects the complex ity of the nervous system, but the overriding message is hope for new and better drugs to treat those diseases that rob us of ourselves.

Twelve review articles by leading experts critically summarize the state of knowledge concerning molecular, anatomical, physiological and behavioural aspects of NPY and its congeners.

Psychopharmacology may be defined as the study of the effects of drugs on behavior. Numerous excelIent texts and review articles are available that serve to outline recent progress in psychopharmacology (particularly the Handbook of Psychopharmacology series, edited by L.

This text is a treatise drawing together and critically examining the current explosion of experimental and clinical research on the metabolism, nutrition, pharmacology, toxicology, pathology, neuropsychology, and developmental neurobiology of trace elements.

Research into the processes of tolerance and sensitization has escalated at a substantial rate in recent years, presumably because of the fundamental importance of understanding the long-term, as opposed simply to the initial, acute effects of drugs.

The even more colo- ful "book of life" metaphor gave the promise that reading that book would lead to a veritable outpouring of new cures for diseases, hundreds of new drug targets, and a brave new world of medicine.

This work reviews the progress that has been made in strategies for testing possible mechanisms for neuronal cell death resulting in an understanding of the molecular epidemiology of dementia.

A distinguished international panel of authors define our current understanding of neuronal damage after ischemia and critically review the significant recent developments and progress in cerebrovascular accident (CVA) drug trials, both in animal models and in the clinical setting.

Prominent experimentalists critically review the animal models widely used in developing powerful new therapies for central nervous system diseases.

A distinguished panel of internationally recognized neuroscientists comprehensively review the involvement of and changes in glial cells both during the normal aging process and in the major disorders of old age.

In Neurobiology of Aggression: Understanding and Preventing Violence, leading experts in the fields of the neurobiology, neurochemistry, genetics, and behavioral and cultural aspects of aggression and violence provide a comprehensive collection of review articles on one of the most important cross-disciplinary issues of our time.

A distinguished international panel of authors define our current understanding of neuronal damage after ischemia and critically review the significant recent developments and progress in cerebrovascular accident (CVA) drug trials, both in animal models and in the clinical setting.

In Motor Activity and Movement Disorders thirteen state-of-the-art articles explicate forefront research methodologies for measuring and interpreting motor activity in animals, as well as their applications to preclinical and clinical research involving motor disorders.

This book, covering many key aspects of autonomic nervous system maturation, was suggested by the success of a symposium on the developing autonomic nervous system held at the Spring 1982 meeting of the Federation of American Scientists for Experi- mental Biology (Federation Proceedings 1983, 42, 1609).

There is also increased coverage of the animal models used in the study of neuroinflammatory mechanisms, of the new imaging methods that allow the noninvasive evaluation of microglial activation in human neurodegernerative disorders, and of the role of neuroinflammation in amyloid-dependent neuronal lysis.

There is also increased coverage of the animal models used in the study of neuroinflammatory mechanisms, of the new imaging methods that allow the noninvasive evaluation of microglial activation in human neurodegernerative disorders, and of the role of neuroinflammation in amyloid-dependent neuronal lysis.

Their discussion of the fundamental biology of NSCs illustrates the signaling pathways that regulate stem cell division and differentiation, and defines the methods of NSC expansion and propagation, neuromorphogenesis, the factors determining cell fate both in vitro and in situ, and the induction of self-reparative processes within the brain.