Bücher der Reihe Current Cancer Research

Cancer is fundamentally a disease of abnormal cell proliferation: Cancer cells multiply when and where they should not.

Cancer gene therapy is a novel therapy that targets the underlying genetic defects in the cancer cell. Progress in this field has been rapid and gene therapy promises to further extend personalized cancer treatment. In this volume leading experts have contributed their experience in developing gene therapies for a variety of cancers.

With the explosion of information on autophagy in cancer, this is an opportune time to speed the efforts to translate our current knowledge about autophagy regulation into better understanding of its role in cancer.

This volume will provide a contemporary account of advances in chemical carcinogenesis. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens.

Cancer is fundamentally a disease of abnormal cell proliferation: Cancer cells multiply when and where they should not.

Cancer gene therapy is a novel therapy that targets the underlying genetic defects in the cancer cell. Progress in this field has been rapid and gene therapy promises to further extend personalized cancer treatment. In this volume leading experts have contributed their experience in developing gene therapies for a variety of cancers.

Molecular Determinants of Radiation Response includes chapters by expert authors who detail the present understanding of key DNA damage response pathways and proteins.

Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980's with its identification as an effector of phorbol esters, natural products with tumor promoting activity.

This volume will provide a contemporary account of advances in chemical carcinogenesis. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens.

Chapters on epigenetic mechanisms, nuclear receptors, cell surface antigens, the hypoxic leukemia microenvironment, stem cells and leukemia metabolism provide insights into leukemia cell vulnerabilities.

This book examines evolving paradigms in antigen presentation, dendritic cell biology, innate response and immunosuppressive mechanisms and strategies for manipulation of the immune system to treat neuroblastoma, leukemia, melanoma, lung cancer and more.

With the explosion of information on autophagy in cancer, this is an opportune time to speed the efforts to translate our current knowledge about autophagy regulation into better understanding of its role in cancer.

This proposed volume will provide a comprehensive view of Burkitt's Lymphoma from the diagnosis to potential animal models for this disease and include a view from physicians who have a up close view of the patients in populations where the disease is rampant.