Bücher der Reihe Current Topics in Microbiology and Immunology

HIV-1 inhibitor resistance is discussed in detail, and critical assessments as to what will be required of future antiretrovirals in order to halt viral replication, reduce viral resistance, and alter the state of viral latency are presented.

This volume examines all facets of the complex biology of Immunoglobulin E (IgE) antibodies, which play an essential role in the pathophysiology of allergic diseases and immunity to parasites.

This volume reviews the current state of research concerning bacterial virulence factors and the infection biology of Helicobacter pylori, which is the leading cause of peptic ulcers and gastric cancer worldwide.

Streptococci are Gram-positive bacteria that cause a wide spectrum of diseases, such as pharyngitis, necrotizing fasciitis and streptococcal toxic shock syndrome, as well as rheumatic fever and rheumatic heart disease as sequelae.

This volume examines all facets of the complex biology of Immunoglobulin E (IgE) antibodies, which play an essential role in the pathophysiology of allergic diseases and immunity to parasites.

One Health is an emerging concept that aims to bring together human, animal, and environmental health. In the 19th and early 20th centuries this was not the case-then researchers like Louis Pasteur and Robert Koch and physicians like William Osler and Rudolph Virchow crossed the boundaries between animal and human health.

Streptococci are Gram-positive bacteria that cause a wide spectrum of diseases, such as pharyngitis, necrotizing fasciitis and streptococcal toxic shock syndrome, as well as rheumatic fever and rheumatic heart disease as sequelae.

One Health is an emerging concept that aims to bring together human, animal, and environmental health. In the 19th and early 20th centuries this was not the case-then researchers like Louis Pasteur and Robert Koch and physicians like William Osler and Rudolph Virchow crossed the boundaries between animal and human health.

Human coronaviruses caused the SARS epidemic that infected more than 8000 people, killing about ten percent of them in 32 countries. This book provides essential information on these viruses and the development of vaccines to control coronavirus infections.

This book illustrates, that the fungal cell wall is critical for the biology and ecology of all fungi and especially for human fungal pathogens. Readers will learn, that the composition of the fungal cell wall is a unique structure, which cannot be found in the human host.

Negative-strand RNA viruses, so named because of the polarity of their genomic RNA to mRNA, include important human and non-human pathogens.

This special issue on Notch regulation of the immune system summarizes recent advances and covers multiple aspects of Notch signaling within the hematopoietic and the immune system.

it will be useful to basic and animal virologists, ecologists, epidemiologists, physicians, and others interested in emerging infectious viral diseases, as it showcases the multidisciplinary efforts required to understand the genesis, spread and hopefully, control, of a group of lethal emerging zoonotic pathogens.

Reviews the research on using genetically engineered plants and plant viruses to produce products for medicine and industry. This book contains some discussions on the potential benefits and risks involved in producing pharmaceuticals in plants and the challenges of bringing such products to market.

The B lymphocyte lineage represents an important paradigm for exploring the molecular mechanisms underlying cell fate specification, differentiation and cellular activation. Major advances have been achieved in our understanding of the transcriptional control of early B cell development and terminal plasma cell differentiation.

Moreover, several human diseases are caused by retroviruses, including AIDS, adult T-cell leukemia and the neurological disease HAM/TSP. The topic of this volume is a relatively unknown animal retrovirus, jaagsiekte sheep retrovirus, the causative agent of transmissible lung cancer in sheep -ovine pulmonary adenocarcinoma.

However, to the editor's knowledge, genuine human foamy viruses do not exist, but several trans-species transmissions of different simian foamy viruses from monkeys and apes to human hosts.

Antibodies are central to vaccines and it is becoming increasingly apparent that understanding how antibodies combat viruses could be crucial in a new era of vaccine development. This book describes the state of the art in explaining the anti-viral activity of antibodies at the molecular level, with chapters from many of the leaders in the field.

Clostridium difficile has been recognized as the cause of a broad spectrum of enteric disease ranging from mild antibiotic-associated diarrhea to pseudomembranous colitis.

Corepressors are newly discovered assemblies of proteins that play essential roles in eukaryotic gene regulation. Recent discoveries about corepressors have provided new insights into the molecular basis of gene regulation, and have established surprising connections between the mechanisms of action of a wide variety of transcriptional regulators.

It has been recognized that viruses can induce neuronal damage by a variety of mechanisms. The specific mechanisms of damage involved in retroviral infections and in prion diseases of the nervous system are reviewed, and finally how autoimmune diseases can lead to neuronal damage.

This volume should be informative for both experts as well as newcomers to the field of TLRs in the nervous system based on its coverage of basic TLR biology as well as specialization to discuss specific diseases of the nervous system where TLR function has been implicated.

Clearly, an in-depth study of bacterial infectious strategies, as well as the host cellular and immune responses, presented in each chapter of this book will provide further insight into the critical roles of the host innate and adaptive immune systems and their importance in determining the severity or completely preventing infectious diseases.

The study of viruses necessarily involves dissecting the intimate details of cellular pathways. Viruses have often been employed as tools in studying cellular pathways, as was done by early retrovirologists such as Peyton Rous in attempting to understand the mechanism of cellular transformation and oncogenesis.

Scientific research on dengue has a long and rich history. Dengue and dengue hemorrhagic fever, which assumed pandemic proportions during the latter half of the last century, have shown no indication of slowing their growth during this first decade of the twenty-first century.

The chemokine system is also important both for the crosstalk between malignant cells and their neighbouring nonmalignant stromal cells (including endothelial cells) as well as for immunoregulation in patients treated with allogeneic stem cell transplantation.

Although severe hypoxia is generally toxic for both normal tissue and tumors, neoplastic cells gradually adapt to prolonged hypoxia though additional genetic and genomic changes with a net result that hypoxia promotes tumor progression and therapeutic resistance.

The means by which non-enveloped viruses penetrate cellular membranes during cell entry remain poorly defined.

During the late 1970's the application of hybridoma technology led to an explosion in the discovery and characterization of proteins expressed at the surface of hematopoietic cells.