Bücher der Reihe Developments in Cardiovascular Medicine

Because the constant flow of information makes it nearly impossible to construct a timely book on advances in cardiology, the chapters in this volume describe the current concepts in cardiology and their underlying rationale, rather than attempting a comprehensive review of the most recent papers in each discipline.

In recent years methods have been developed to study cardiac function, myocardial blood flow and myocardial metabolism with radionuclides.

Dutch Society of Ultrasound in Medicine and Biology Dutch Heart Foundation, The Hague, the Netherlands European Society of Cardiology Financial support was given by Interuniversity Institute of Cardiology, Amsterdam, the Netherlands University-fund Rotterdam Foundation, Rotterdam, the Netherlands Dutch Heart Foundation, The Hague, the Netherlands.

This time, we decided to broaden the basis of the meeting and have a three-day program of parallel sessions, combining invited papers, free com munications and posters. We decided, however, to maintain one of the most striking features of the last meeting- having the complete proceedings available at the time of the meeting.

Proceedings of a Satellite Symposium of the XXX International Physiological Congress, July 8-11, 1986, Winnipeg, Canada

In Advanced Imaging in Coronary Artery Disease, the role of several imaging techniques in diagnosing atherosclerosis, assessment of myocardial ischemia, myocardial viability, and heart failure are broadly discussed.

Cardiac Positron Emission Tomography: Viability, Perfusion, Receptors and Cardiomyopathy describes the most recent developments in cardiac PET as these are related to myocardial viability and myocardial perfusion studies of syndrome X.

In open heart surgery, protection of the myocardium against injury by ischemia-reperfusion is an issue of utmost clinical interest.

This book of 35 chapters contains an up-to-date discussion of various arterial and venous illnesses presenting major clinical applications ranging from basic pathology, haemodynamics and haemorheology to clinical features and management.

In the past, coronary arteriography was the only modality available to provide high quality images of the coronary anatomy.

This atlas presents over 160 illustrations, with 116 in color, and illustrates the capacity of multidetector CT for the analysis of the anatomy of the coronary arteries. The multidetector CT scanner speeds diagnosis and treatment of patients. Multidetector CT provides clear pictures and takes less time than other non-invasive techniques.

An important and recent technical advancement in SPECT has been ECG-gated myocardial perfusion SPECT to generate simultaneous myocardial perfusion and function information from a single study.

a process brought about by the insertion of a gene coding for a foreign protein into target cells resulting in the synthesis of the foreign protein For gene therapy, a tmnsferred therapeutic gene must be expressed at a level beneficial for the patient.

All physicians practicing medicine encounter patients suffering from cardiovascular disease. In other families the search for a disease causing gene is ongoing and the possibilities to find genes and to unravel the pathophysiology of the disease is limited by the lack of patients.

Comprises an account of existing knowledge on the subject of cardiomyopathy and heart failure. This volume covers various major investigational and clinical aspects of the topic. It provides syntheses as well as reviews, offering a multidisciplinary and international perspective. It is targeted towards practicing physicians and basic researchers.

Valve Surgery at the Turn of the Millennium covers valvular heart disease in the aortic and mitral valves in the adult patient. Special attention is given to the important issue of optimal timing, the role of echocardiography in the peri-operative period and assessment of adequate prosthetic valve function and dysfunction. New developments in valvular surgery are discussed and the surgical view on choice of valve replacement devices and of the approach of endocarditis is reviewed.

This book contains the manuscripts of the majority of the papers given during the symposium 'Improvement of Myocardial Perfusion' which was held from Sep tember 27-29,1984 in Mainz/Germany.

Although clinicians have recognized the importance of inflammatory mediators in the pathogenesis of heart disease for well over 200 years, it has taken nearly as many years for clinicians and scientists to focus on the basic biological mechanisms by which inflammatory mediators contribute to the pathogenesis of cardiac disease states.

He is currently a research scientist in the Department of Physiology and Cellular Biophysics at the College of Physicians and Surgeons of Columbia University. Dr. Andrew R.

Because the constant flow of information makes it nearly impossible to construct a timely book on advances in cardiology, the chapters in this volume describe the current concepts in cardiology and their underlying rationale, rather than attempting a comprehensive review of the most recent papers in each discipline.

This atlas presents over 160 illustrations, with 116 in color, and illustrates the capacity of multidetector CT for the analysis of the anatomy of the coronary arteries. The multidetector CT scanner speeds diagnosis and treatment of patients. Multidetector CT provides clear pictures and takes less time than other non-invasive techniques.

Autopsy derives from the greek word autopsia, which means act of seeing with one's own eyes. It remains the most objective and accurate method to understand human. disease. Unfortunately, the volume of autopsies in teaching hospitals has decreased dramatically over the past years. The crucial factors that account for this are the recent progress and development of new technologies, especially in diagnostic imaging, immunology, cell biology and genetics. Additionally, the perpetual fear of legal liability by physicians accounts for its further decline. Consequently, physicians and medical students are engaged in fewer autopsies and are not reaping the rich educational rewards that accompany these examinations. The purpose of the autopsy is not only to establish the cause of death, but also to determine the nature and course of the disease process. Our goal with this book is to emphasize the importance of the post-mortem exam and the correlation between pathologic material and clinical data by analyzing actual cases with problem-based methodology. The focus of this handbook is on cardiovascular disease, and when appropriate, other disease categories are included if they have an impact on cardiovascular function. The approach is more than the usual clinico-pathological correlation. Rather, we attempt to present the material from the perspective of the autopsy table. We use the clinical data as the initial framework and the autopsy findings to develop a true understanding of the disease and the associated pathophysiology of the condition.

Catheter-delivered therapeutic ultrasound angioplasty is a new technique for use in the treatment of obstructive vascular disease. The treatment differs from balloon angioplasty in that it has been shown experimentally to cause disintegration of calcific and fibrotic atherosclerotic plaques, thrombus dissolution and arterial vasodilation. In contrast to laser technology, ultrasound systems are relatively inexpensive and simple to use and maintain. In the clinical trials detailed in this text, ultrasound angioplasty has been shown to be feasible and safe. Ultrasound Angioplasty is a comprehensive text, addressing the theoretical, experimental and clinical issues. The international contributions reflect the excitement, interest, spirit and cooperation in the research and development of therapeutic ultrasound.

From the Proceedings of the Meeting of the American Section of the International Society for Heart Research (ISHR) at Hilton Head, South Carolina, September 21-24, 1983

Although there are many books on angina, few are devoted to the important problem of how to evaluate drug efficacy in angina pectoris. Drug Evaluation in Angina Pectoris has two fundamental aims: the first is to review the methodological aspects of drug evaluation in stable and unstable angina pectoris; the second is to provide a logical and methodological background for future studies aimed at assessing the ability of medical treatment to improve prognosis. Part I updates the pathophysiology, clinical presentation and prognosis of angina pectoris. Part II aims to `put in numbers' the symptoms and signs of myocardial ischemia, starting from a revision of the currently used parameters. It is extremely important to quantify the variability of the disease for the correct design of clinical trial, a subject dealt with in Part III, which also discusses some clinico-pharmacological aspects of therapy. Part IV is a critical review of the drugs currently used for the treatment of stable and unstable angina, and particularly considers some important unresolved issues concerning their use. The current FDA and EC guidelines for the evaluation of antianginal drugs are briefly discussed in Part V, giving clinical investigators insight into how antianginal drugs are evaluated by regulatory agencies and what is considered as proof of a valid efficacy/tolerability ratio. Drug Evaluation in Angina Pectoris will assist discerning cardiologists, pharmacologists, and advanced students of cardiology as well as innovative pharmaceutical companies, all of whom need to understand what angina is, how to evaluate treatment, and how to judge the agents used in its treatment.

This book is based on papers presented at a Symposium held in Seoul, Korea in 1992. The idea for the symposium developed naturally from work in which Professor Yung E Earm, at Seoul National University, had been involved both in my laboratory in Oxford and in his own laboratory in Seoul concerning the possible role of certain amino acids, like taurine that are strongly concentrated by the cells of the heart, and the relationship between such acids and membrane ionic currents. The first obvious question was whether it is possible to identify the transport mechanisms involved for taurine and whether they are electrogenic. The second question is what function could be served by such processes: does taurine play an essential role in cardiac tissue and is this important in protecting the heart from disease? With his colleagues in the Korean Physiological Society, Professor Earm set about the task of fmancing and organizing a meeting at which some of the world's leading cardiac electrophysiologists and taurine specialists could discuss these questions. The fmance was generously provided by the Dong-A Pharmaceutical Company, one of the leading scientific companies in Korea.