Bücher der Reihe Developments in Oncology

In creating this book, we aimed to cover a broad "bench to bedside" research spectrum ranging from: genetic, molecular and cellular analyses to epidemiological studies, refinements in local treatment strategies and new biologically based non-hormonal treatments for systemic disease.

Proceedings of the 1st International Conference, October 11-14, 1989, Detroit, Michigan, USA

Proceedings of the International Workshop on Monoclonal Antibodies and Breast Cancer, held in San Francisco, California, November 8-9, 1984

Proceedings of the Symposium on Biochemistry and Molecular Genetics of Cancer Metastasis, Bethesda, Maryland, March 18-20, 1985

Proceedings of the Seventeenth Annual Detroit Cancer Symposium, held in Detroit, Michigan, April 12-13, 1984

The observation in the 1950s that nitrogen mustard and other toxic chemicals could induce antitumor responses in patients with refractory lymphoma initiated a massive search for active chemotherapeutic agents.

Proceedings of the Biennial Conference for the International Association of Breast Cancer, Miami, Florida, March 1-5, 1987

KENNETH A. FOON and ALTON C. MORGAN, JR. Passive immunotherapy using heteroantisera for the treatment of cancer in animals and humans has been studied for over 50 years. Attempts have been made to treat animal tumors with sera from immunized syngeneic, allogeneic, or xenogeneic animals. A number of studies of passive immunotherapy using heterologous antisera in humans have also been performed. These studies have generally been attempted in patients with large tumor burdens, and as would be expected, results have been transient at best. A wide variety of solid tumors as well as leukemias and lym­ phomas have been treated with antisera raised in sheep, horses, rabbits, and goats. Problems such as anaphylaxis, serum sick­ ness, and severe cytopenias have been encountered with these antisera. There are a number of potential mechanisms by which unconju­ gated antibodies might be cytotoxic to tumor cells. Antibodies bound to the cell surface membrane of tumor cells may lead to cell lysis by complement-dependent or antibody-dependent cellu­ lar cytotoxicity. Circulating tumor cells bound by antibody may be more susceptible to phagocytosis by the reticuloendothelial system. Antibody bound to the cell surface membrane of tumor cells may enhance immunogenicity of the tumor cell leading to activation of the host's immune system.

This volume contains the proceedings of the latest in a series of international symposia on advances in neuro-oncology, held September 26-29, 1990, in San Remo, Italy and sponsored by the University of Pavia, I.R.C.C.S.

Recent research has discovered that for many of these `sporadic' (non-familial) cancer cases, defects or aberrations in certain metabolic genes not previously associated with genetic cancer risk may contribute to either causing the disease or at least increasing the chances of developing cancer.

Proceedings of the 8th Annual ECP Symposium

The hematopoietic system plays roles that are crucial for survival of the host: delivery of oxygen to tissues, arrest of accidental blood leaking from blood vessels, and fending off of invading microbes by humoral, cell-mediated, and phagocytic immunity.

Molecular Genetics of Colorectal Neoplasia A Primer for the Clinician provides the latest information on the genetics of colorectal cancer within a context of basic genetics, describing the subject in understandable language and making it clinically relevant.

Colorectal cancer is a collective term for a heterogeneous group of diseases. It has been stated that clinicians can contribute to the goal of reducing mortality from cancer by asking each patient about his or her family history of cancer.

Proceedings of the Second International Conference on Malignant Lymphomas, Lugano, Switzerland, June 13-16, 1984

Proceedings of the First International Symposium on the Organ Directed Toxicities of Anticancer Drugs convened at Burlington, VT, June 4-6, 1987.

Causes and Control of Colorectal Cancer: A Model for Cancer Prevention is a ground- breaking monograph which takes a global, multidisciplinary approach to the causes, carcinogenesis and control of colorectal cancer.

Proceedings of the International Symposium on Sarcomas, Tarpon Springs, FL, October 8-10, 1987

The assessment of tumour response after treatment is one of the most important challenges in Oncology and the picture is so often complicated by the effects of therapy itself.

Relapse of leukemia following successful remission-induction therapy remains a major obstacle in the treatment of patients with acute leukemia.

The digestive organs are the most frequent site of cancer in the world, accounting for approximately 30% of all malignant tumors. The most remarkable shift has been the decrease in gastric cancer rates occurring concomitantly with an increase in colon cancer rates in most 'western' industrialized societies.

In recent years much progress has been made in knowledge and understanding of the biology of cutaneous melanoma. A post-graduate Boerhaave course "Cutaneous Melanoma and Precursor Lesions" was held at Leiden University on 12 and 13 April,.

During the past four decades knowledge about biological effects of ionizing radiations on mammalian cells, normal tissues and tumours has increased enormously and has enabled radiotherapists to obtain a better insight into the advantages and disadvantages of cancer treatments with modified regimens of irradiations and combinations with chemotherapeutic agents. Even for the older scientists and clinicians who have wit­ nessed all these developments and have contributed to the vast amount of information, it is difficult to integrate this knowledge and to apply it in their daily work. For younger workers it is often difficult to select the important main concepts and results from the overwhelming number of publications. It is evident that a book which provides an integrated view of basic and applied radiation oncology can be of great value to students, scientists and, most importantly, to clinicians who can devote only part of their time to the task of understanding the radiobiological background of their application of radiation in cancer treatment. This book "Radiation Oncology" is written by a radiotherapist who has for a long time participated in the integration of basic knowledge and clinical experience. He has selected radiobiological information which is considered important to radiotherapy and in the description and interpretation of normal tissue tolerance and tumour eradication probability, he illustrates how basic knowledge can be applied clinically.

Proceedings of a symposium presented at the University of Southern California, Department of Pathology and the Kenneth J. Norris Cancer Hospital and Research Institute, Los Angeles, U.S.A., November 16-17, 1984

Proceedings of the 2nd International Conference, September 17-21, 1991, Berlin, Germany