Bücher der Reihe Endocrine Updates

Pituitary Disease brings together an international panel of experts who summarize the most recent and exciting advances in the diagnosis and treatment of pituitary disease. clinical scenarios underpinning each type of pituitary tumor as well as their diagnosis and treatment.

Sex Hormone Replacement Therapy addresses important issues in contemporary endocrinology. Its major emphasis is on the consequences of the menopause and on androgen deficiency in the absence of overt disease of the hypothalamus and/or pituitary in men. The use of hormone therapy for the primary prevention of cardiovascular disease in post-menopausal women has become an area of major debate, and the pros and cons are examined in detail. Secondary prevention also remains controversial and is addressed in this volume. An issue of particular concern is the treatment of estrogen deficiency symptoms in women with the diagnosis of breast cancer. Whether older men with some androgen deficiency symptoms and equivocally low plasma testosterone concentrations should be treated with androgens is also a matter of great debate, as is the efficacy and safety of plant estrogens in the treatment of menopause-related complaints. Sex Hormone Replacement Therapy will be of interest to students and non-specialists, as well as a wide range of medical practitioners including endocrinologists, gynecologists, rheumatologists and cardiologists.

The exponential growth in our knowledge on the pathophysiology of hypothalamic-pituitary-thyroid axis and, in particular, of thyroid hormone action, largely stems from the studies on the various syndromes of resistance to the hormones involved in the function of the axis. These syndromes essentially encompass two forms, i. e. the resistance to thyroid hormones and that to TSH action. The contribution of molecular biology has been fundamental in understanding the etiology of these different thyroid disorders and led to the discovery of new pathogenetic mechanisms, e. g. the dominant negative effects of a mutant protein on the normal one. In this book, I have assembled an internationally renewed group of experts devoted to the studies of both basic and clinical thyroidology. Taking the syndromes of resistance as a template, the novelties on the mechanisms of action of the various hormones, the etiopathogenesis of the syndromes, the instruments for the diagnosis, as well as the pitfalls in managing these diseases, are deeply revisited. The insights from different animal models are discussed, with particular focus on tissue specific action of thyroid hormones, as well as on the still enigmatic mechanism of negative feedback control of thyroid hormones on TSH secretion and the different etiologic mechanisms causing thyroid hormone resistance in patients without mutations in the thyroid hormone receptor ~. The role of the structure of thyroid hormone and TSH receptors in designing agonist or antagonist molecules is extensively debated. Moreover, new forms of congenital or acquired resistance to thyroid hormones are presented.

Also to be decided is whether orbital lymphocytes from GO patients specifically recognize this receptor, and what factor or factors unique to Graves' dIsease might stimulate TSHr expression in orbital cells.

RNA binding proteins are an exciting area of research in gene regulation. Unlike DNA, the structure of RNA is highly variable and conformationally flexible, thus creating a number of unique binding sites and the potential for complex regulation by RNA binding proteins.

Pituitary adenomas account for 10-15% of all intracranial tumors and they frequently impair fertility. This book intends to update knowledge on this topic, mainly regarding fertility restoration as well as gestational and post gestational management of patients with pituitary tumors.

The student of Cushing's Disease and the HPA axis will find elucidation of the latest basic scientific advances, coupled with patient friendly guidelines for clinical diagnosis and management of an extremely challenging neuroendocrine disorder.

Calcium-Sensing Receptor provides an overview of various aspects of the calcium receptor's biochemistry, physiology and pathophysiology that is suitable both for those who have been working in the field of Ca2+0-sensing as well as those who are new to this discipline.

Covers the scientific findings of the syndromes of hormone resistance in the HPT axis - thyroid hormone resistance and resistance to TSH action. This book covers the mechanisms of action of the various hormones, etiopathology of the syndromes, instruments for diagnosis, as well as the difficulties in managing these diseases.

RNA binding proteins are an exciting area of research in gene regulation. Unlike DNA, the structure of RNA is highly variable and conformationally flexible, thus creating a number of unique binding sites and the potential for complex regulation by RNA binding proteins.

Because of its relative rarity and favorable outcome, it has not been feasible to assess medical interventions for thyroid cancer using randomized prospective trials.

Rapid progress is now being made in (i) understanding the molecular interaction between autoantibodies and the TSH receptor, (ii) identifying the genes that contribute to the predisposition to disease, (iii) developing an animal model of Graves' disease, and (iv) identifying the long-sought orbital antigen in ophthalmopathy.

Be cause of the historical and practical importance of knowledge regarding the hypothala mus-Iactotroph axis, the first chapters of this volume are dedicated to reviewing the physiology, development, and cell biology of lactotroph regulation.

Diabetes mellitus is rapidly increasing in prevalence throughout both developed and developing countries. This comparatively small group of patients (-10% of diabetes) presents relative early in life "30 years of age) compared to the more common late onset type 2 diabetes.

Presenting detailed information on treatment of the obese patient, this handy, concise title is designed not only to educate practitioners about obesity but, most importantly, to provide practical strategies in the comprehensive approach to treating this disease.

The American Cancer Society recently estimated that about 45,000 new cases of thyroid cancer will be diagnosed in the United States, with three-quarters occurring in women.

This timely book provides an overview of topics related to obesity. These include associated health risks, childhood obesity, genetics, evaluation, treatment, behavioral strategies, and successes and failures in preventing obesity.

This reality is unlikely to change and mandates that we develop strategies to prevent aging-related diseases like osteoporosis before they become manifest. Osteoporosis: Genetics, Prevention and Treatment places emphasis on the (1) genetic predisposition, (2) early recognition and (3) prevention of osteoporosis.

Polycystic ovary syndrome (PCOS) is a classic female infertility condition affecting an estimated 6-10% of all women, many of whom are unaware of the problem. A disease that affects women from adolescence to menopause, PCOS is the single most common endrocrinologic abnormality affecting women.

This reality is unlikely to change and mandates that we develop strategies to prevent aging-related diseases like osteoporosis before they become manifest. Osteoporosis: Genetics, Prevention and Treatment places emphasis on the (1) genetic predisposition, (2) early recognition and (3) prevention of osteoporosis.

This book is an edited collection of the literature on leptin beginning with the discovery of leptin and a study of its affect on animals and in humans. Chapters will focus on the discovery, history, roles and regulation of leptin in all the major areas of physiology, as well as on assay methods, phylogeny and genetics.

This book is an edited collection of the literature on leptin beginning with the discovery of leptin and a study of its affect on animals and in humans. Chapters will focus on the discovery, history, roles and regulation of leptin in all the major areas of physiology, as well as on assay methods, phylogeny and genetics.

Diabetes mellitus is rapidly increasing in prevalence throughout both developed and developing countries. This comparatively small group of patients (-10% of diabetes) presents relative early in life "30 years of age) compared to the more common late onset type 2 diabetes.

Calcium-Sensing Receptor provides an overview of various aspects of the calcium receptor's biochemistry, physiology and pathophysiology that is suitable both for those who have been working in the field of Ca2+0-sensing as well as those who are new to this discipline.

The student of Cushing's Disease and the HPA axis will find elucidation of the latest basic scientific advances, coupled with patient friendly guidelines for clinical diagnosis and management of an extremely challenging neuroendocrine disorder.

This volume includes the latest information on the abuse by athletes of exogenous hormones. It gives sports medicine practitioners and endocrinologists a comprehensive overview of the complex interactions between physical activity and the endocrine system.

Thyroid function tests are performed by essentially all medical practitioners across every clinical setting. In this book, leading experts in the field provide clinically practical information from the most recent scientific advances.