Recent advances in molecular biology have shown GTPases and phosphoproteins to be the paramount molecular switches uti- lized intracellularly in biological systems. The origins of the GTPase switch appear to be almost as ancient as life it- self, and through evolution nature has adapted this switch to a variety of purposes. In this two-volume work a broad survey of the major classes of GTPases is presented. The role of GTPases in ensuring ac- curacy during protein translation, a new look at the trimeric G-protein cycle, the molecular function of ARF in vesicle coating, the emerging role of the dynamin family in vesicle transfer, GTPases which activate GTPases during nascent protein translocation, and the many roles of ras-related proteins in growth, cytoskeletal polymerization, and vesicle transfer, are all described in 80 chapters by the leading authorities in their fields. Both detailed knowledge of specific systems or proteins and general principles of structure and function are offered. Much of this information has never been published before. At the rate the extended family of GTPases is growing it becomes increasingly unlikely that we will again get it to sit for a group portrait such as this. Therefore, the volume has the chance to become t h e reference work for GTPases.
This book is an update of the treatment of hyperlipidemia, necessary due to the identification in recent years of molecular mechanisms of atherogenesis. Emphasis is on the disease etiology of arteriosclerosis, the treatment of associated or causing diseases and treatment by dietary means or hypolipidemic drugs.
This rapidly-evolving field has witnessed the PCR combinatorial cloning of vast immunological diversity, in vitro mutagenesis of MAbs, MAbs created by transgenic animals, novel expression systems in plants, animals and lower systems, as well as a rich variety of genetically modified MAbs as potential therapeutic agents.
Comprehensive in its scope, this book provides an up-to-date, in-depth treatment of the field, with particular emphasis on the integration of research findings from diverse approaches and how these findings might influence future investigations.
A comprehensive and systematic survey of the present knowledge of the structure and physiological functions of smooth muscle and its response to endogenous substances and pharmacological agents.
The book also has chapters on emerging conceptual problems including resistance to metal toxicity effects on gene expression, alongside principles regarding drug-chelation of metals, the potential use of prophyrins as indicators of metal exposure and toxicity.
It was found that such essential functions as the flow of pancreatic juice and emptying of bile into the intestine were regulated by two hormones, secretin and cholecystokinin, respectively. In spite of the difficulties in obtaining secretin American authors succeeded in keeping the interest in the secretin test alive.
This volume describes the present state of the art in carcinogenesis, possibilities for cancer prevention, and gives genetic background in cancer development. Attention is given to the host-environment interaction, considering how this interaction may lead to cancer formation and how it can be utilised in cancer prevention.
Sphingolipids are lipid components of the plasma membrane in eukaryotic cells. This book on sphingolipids provides insights into the basics of sphingolipid biology and drug development, with a particular emphasis on the sphingolipid derivative ceramide.
The degree to which man is malleable and perfectible by social forces is not known nor do we know the true desirability of socializing individuals to the extent that their behavior does not deviate from social norms.
Sphingolipids are lipid components of the plasma membrane of eukaryotic cells with an important function in signaling mechanisms in the cell. The function of Sphingolipids in cell signaling with regard to infectious and lung diseases, cancer, cardiovascular diseases and neuropsychiatric disorders are described and treated in distinct parts.
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Absorption from the Stomach . . . . . . . . . . . . . . . . . . Intestinal Absorption of Macromolecules . Active Transport across the Intestinal Epithelium . Effect of EDTA on Drug Absorption from the Intestine .
With contributions by numerous experts
A review of the current state of the clinical and basic science of the pharmacology of sleep. For the first time in one single volume, both the basic mechanisms of sleep, and the basic and clinical aspects of the pharmacology of sleep are dealt with in a thorough, comprehensive and authoritative manner.
with contributions by numerous experts
Antisense technology may result in dramatic changes in the therapy of many diseases and may provide tools to dissect pharmacological processes and to confirm the roles of various genes. In this volume, progress in the understanding of antisense technology and its use in creating new drugs is discussed.
Of all the parasitic diseases that beset man in the warmer parts of the world, malaria is still the major cause of morbidity and mortality.
The term "intestinal permeation" refers to the process of passage of various substances across the gut wall, either from the lumen into the blood or lymph, or in the opposite direction.
With contributions by numerous experts
It is fourteen years since insulin was last reviewed in The Handbook of Ex perimental Pharmacology, in volume 32. We therefore decided to limit the present volume to the following areas: insulin chemistry and structure, insulin biosynthesis and secretion, insulin receptor, and insulin action at the cellular level.
I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin Madison.
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