Bücher der Reihe Immunology and Medicine

Immunotherapy began in 1774 when the Dorset farmer Benjamin Jesty inoculated his wife and two sons with the pus from the teat of a cow suffering from cow pox, using his wife's knitting needle as a vaccinating implement.

The AIDS epidemic has popularized immune deficiency and has led to a rapid increase in the funding for research into the effect of viruses on immunity. AIDS is an important precedent, and it is likely that other less pathogenic retroviruses will eventually turn dut to cause some of the rarer immunodeficiency disorders in children and adults.

After Maureen Young's summary of fetal physiology, Matteo Adinolfi describes the development of the immune system in the fetus, including new information that allows more accurate speculation concerning the gestational age at which fetal immune responses of various kinds may begin.

Recent developments in the field of cellular pathology and molecular biology have had a major impact on our ability to diagnose lymphoreticular disease and on our understanding of many of the disease processes which contribute to lymphoreticular pathology.

Until recently, the contribution of immunological knowledge to the under standingand management ofENTdisorders was slight, being largely confined to the appreciation that many rhinitic patients were allergic.

The role of the immune response in both the pathology of liver disease and in the modulation ofliver injury has been the subject of intense research. Further chapters are devoted to the three major autoimmune liver diseases which are thought to be the result of loss of tolerance to autologous liver tissue.

New vaccines under development include vaccines against hepatitis B, hepatitis A, malaria, vaccines for typhoid, cholera, rota virus infection and other diarrhoeal diseases, leprosy, rabies, the acquired immune deficiency syndrome (AIDS), rubella, EB virus, schistosomiasis and other infections.

Of central importance in autoimmunity is the relationship between antigen pre senting cells (including B cells) expressing MHC class II molecules, autoan tigenic peptides, T helper lymphocytes, and various effector cells.

Our understanding of inflammation has increased rapidly in recent years, due in large part to the impact of molecular biology and gene identification and cloning.

In that relatively short period of time, study of the disease has moved from the level of early clinical description to exhaustive and extensive laboratory characterization of the human immunodeficiency virus (HIV), the immune responses directed towards it and reasons for their failure.

Gastrointestinal diseases present a considerable problem in human medicine in terms of both morbidity and mortality. the immunological features of idiopathic inflammatory gut diseases such as Crohn's disease and intractable diarrhoea; the iatrogenic diseases of the gut such as graft-versus-host disease and small bowel allografts;

Connective tissue diseases demand study because of their frequency, morbidity and mortality. The book presents up-to-date reviews of the immunological basis of connective tissue diseases as it impacts on diagnosis, pathogenetic concepts, disease monitoring and management.

Infection with the human immunodeficiency virus is characterized by the destruction of the host immune system as also reflected by a progressive loss of CD4-positive T-cells. It describes the clinical aspects of primary infection, the different clinical outcomes of HIV-1 infection, and strategies for anti-viral treatment.

These advances are now facilitating research into the structure of the complement proteins, the nature of the complement deficiency syndromes, the regulation of complement gene expression and the role of complement in different diseases.

Gastrointestinal diseases present a considerable problem in human medicine in terms of both morbidity and mortality. the immunological features of idiopathic inflammatory gut diseases such as Crohn's disease and intractable diarrhoea; the iatrogenic diseases of the gut such as graft-versus-host disease and small bowel allografts;

The role of the immune response in both the pathology of liver disease and in the modulation ofliver injury has been the subject of intense research. Further chapters are devoted to the three major autoimmune liver diseases which are thought to be the result of loss of tolerance to autologous liver tissue.

Connective tissue diseases demand study because of their frequency, morbidity and mortality. The book presents up-to-date reviews of the immunological basis of connective tissue diseases as it impacts on diagnosis, pathogenetic concepts, disease monitoring and management.

Diseases of the gastrointestinal tract are common. Specific disease covered include bacterial infections, human immunodeficiency virus (HIV) infection, coeliac disease, and inflammatory bowel disease.

Until recently, the contribution of immunological knowledge to the under standingand management ofENTdisorders was slight, being largely confined to the appreciation that many rhinitic patients were allergic.

Our understanding of inflammation has increased rapidly in recent years, due in large part to the impact of molecular biology and gene identification and cloning.

Immunotherapy began in 1774 when the Dorset farmer Benjamin Jesty inoculated his wife and two sons with the pus from the teat of a cow suffering from cow pox, using his wife's knitting needle as a vaccinating implement.

In that relatively short period of time, study of the disease has moved from the level of early clinical description to exhaustive and extensive laboratory characterization of the human immunodeficiency virus (HIV), the immune responses directed towards it and reasons for their failure.

Provides a comprehensive account of the known groups of human tumour antigens, and the immune effector cells involved in tumour rejection. This book includes chapters that deals with various major groups of human tumour antigens are included, covering differentiation antigens, testes-associated antigens, CEA, mucin, and viral antigens.

The eye can become involved in immune-mediated diseases that affect it alone or as part of a multi-organ disease process. Much immunological attention has been focused on other organs affected by these processes and the subject of the immunology of eye diseases is a relatively new one.

In 1879 Paul Ehrlich first described the mast cell as a tissue fixed cell contain ing many granules which, when stained with basic dyes, such as toluidine blue, changed the colour spectrum of the dye in a process called meta chromasia.