Bücher der Reihe Methods & Principles in Medicinal Chemistry

A guide to the lastest industry principles for optimizing the production of solid state active pharmaceutical ingredients Solid State Development and Processing of Pharmaceutical Molecules is an authoritative guide that covers the entire pharmaceutical value chain. The authors?noted experts on the topic?examine the importance of the solid state form of chemical and biological drugs and review the development, production, quality control, formulation, and stability of medicines. The book explores the most recent trends in the digitization and automation of the pharmaceutical production processes that reflect the need for consistent high quality. It also includes information on relevant regulatory and intellectual property considerations. This resource is aimed at professionals in the pharmaceutical industry and offers an in-depth examination of the commercially relevant issues facing developers, producers and distributors of drug substances. This important book: * Provides a guide for the effective development of solid drug forms *' Compares different characterization methods for solid state APIs * Offers a resource for understanding efficient production methods for solid state forms of chemical and biological drugs * Includes information on automation, process control, and machine learning as an integral part of the development and production workflows * Covers in detail the regulatory and quality control aspects of drug development Written for medicinal chemists, pharmaceutical industry professionals, pharma engineers, solid state chemists, chemical engineers, Solid State Development and Processing of Pharmaceutical Molecules reviews information on the solid state of active pharmaceutical ingredients for their efficient development and production.

Discusses how to fight Ebola, SARS Corona, and other known or emerging human viruses by building on the successes in antiviral therapy of the past decades Written by leading medicinal chemists and virologists from academia and industry, this book discusses the entire field of antiviral drug discovery and development from a medicinal chemistry perspective, focusing on antiviral drugs, targets, and viral disease mechanisms. It provides an outlook on emerging pathogens such as Ebola, Zika, West Nile, Lassa, and includes a chapter on SARS Coronavirus-2 causing the present pandemic. 'New Drug Development for Known and Emerging Viruses' describes the discovery and development process of antiviral agents for different species of viruses and their targets based on the experiences from seven human viruses for which approved drugs are on the market (HIV, HCV, Influenza, RSV, HBV, HCMV, and HSV). It covers the properties and potential of currently approved antivirals, including combination drugs, and looks at novel antiviral strategies against emerging viruses. * Covers the entire field of antiviral drug discovery and development * Addresses the need for antiviral drugs to combat major health threats such as Ebola, Zika, West Nile, and SARS Coronavirus-2 * Summarizes the successes of the past years in developing ground-breaking medicines against 7 major human viruses, both from the medicinal chemistry and the pharmacological angle * Discusses practical and strategic challenges in the drug discovery and development process, including screening technologies, latency, and toxicity issues 'New Drug Development for Known and Emerging Viruses' is an important book for medicinal chemists, pharmaceutical chemists, virologists, and epidemiologists, and will be of great interest to those in the pharmaceutical industry and public health agencies.

Highlights the critical role of targeted drug delivery for unmet medical needs, by describing a wide range of different approaches for targeting small molecule as well as peptide and macromolecular drugs.

A comprehensive review of small and large open data sources relevant for rational drug design, covering small molecules, drug targets, ligand design, and many more drug-related aspects.