Bücher der Reihe Molecular Biology, Biochemistry and Biophysics Molekularbiologie, Biochemie und Biophysik

A systematic study traced the cause of this absorption, showing that the covered frequency range and the intensity of the absorption were related in a predictable manner to the rate at which ions can interact and form structures differing in volume from the non interacting species.

This book deals primarily with the principal extracellular macromole cules of animal connective tissues. On the other hand, I have not hesitated to search for broad biological principles outside the prevailing conceptual boundaries of animal connective tissues and the lower molecular dimensional levels.

A dinner party at his apartment is among the warmest of my memories, and nothing could please me more than to have the opportunity to introduce him in per son to my colleagues in Western Europe, the Americas, Japan, and Australia.

Certain enzymes with a variety of regulatory and catalytic functions, for example, contain several sites which interact in a highly specific manner such that the affinity of a given site for the substrate is markedly influenced by the state of binding at the other sites.

In 1965 I was asked by Dr. Konrad Springer whether I would consider writing a monograph on "Lampbrush chromosomes and their physiological meaning", and although I accepted in principle I refused to write there and then, or to meet a deadline.

In 1966, a paper entitled "On the formation of a novel adenylylic compound by enzymatic extracts of liver nuclei" from Paul Mandel's laboratory in Strasbourg, France, planted the seed for a rapidly growing new field of biological research focusing on ADP-ribosylation reactions.

The main emphasis is put on the molecular aspect by relating the bioelectrical phenomena, such as the membrane diffusion potentials, pump potentials, or redox potentials, to the properties of the membrane concerned, and, as far as pOSSible, to specific steps of transport and metabolism of ions and nonelectrolytes.

With contributions by numerous experts

Special emphasis has been given to the analysis of the Hill coefficient and its meaning both in thermodynamic terms and in terms of the two allosteric models: the concerted model of Monod, Wyman and Changeux and the sequential model of Koshland, Nemethy and Filmer.

The authors belong to a group formed under the aegis of the Com mission of the European Communities some eight years ago with the object of facilitating the exchange of ideas and inforrration between European scientists working in this field.

The principles described in the latter discus sions are broadly applicable, for example to the promising tech niques of X-ray spectroscopy (utilizing synchrotron radiation) and lanthanide-perturbed, very high-resolution nuclear magnetic resonance spectroscopy.

With contributions by numerous experts

These reac tions, in accord with CZAPEK (1921) and PAECH (1950), are summed up under the term "secondary metabolism", and their products are called "secondary metabolites.

Enzyme kinetics has undergone very rapid growth and development during the past fifteen years and has been well received by the biochemical community.

In the few years since the first edition of this book made its appearance, under takings in the area of protein sequence determination have increased at an almost logarithmic pace.

The treatment is of a survey fashion, in part to pro vide a general over-view of N2 fixation and in part to provide context for the biochemistry and biophysics that follow in the second section.

Although the biochemistry of nucleic acid synthesis is known in general, the precise molecular mechanisms by which deoxyribonucleic acid is replicated or transcribed has still to be clarified.

The tissues and organs covered in six chapters constitute a selected group, representative of areas in which the author has worked and which are thus directly familiar to him, plus several other areas where illustrative and important discoveries have been made.

The alkaloids were of great importance to mankind for centuries, long before they were recognized . Since that time they have remained of great interest to chemists, and now in any month there appear dozens of publications dealing with the isolation of new alkaloids or the determination of the structures of previously known ones.

In the conviction that research into the nature of protamine would shed light on that of other typical proteins, a group of researchers in Germany followed MIESCHER and laid the foundations of protein chemistry.

In recent years bacteriocins, especially colicins, have become widely known to molecular biologists as proteins with peculiar ways of killing bacteria.

Though several recent reviews of the multifacetted problems related to immuno globulins are available, it was decided to publish this survey in the belief that know ledge of the genetic markers of immunoglobulins prqvides such information about immunoglobulin differentiation and its control as cannot be obtained from other sources.

Accordingly, most equations, though developed on the basis of a mobile carrier (ferryboat) model, should apply equally to a conformational model, with an appropriate reinterpretation of the symbols. The kinetic equations are kept to the minimum required to describe the model concerned and to relate it to the corresponding thermodynamic equations.

This monograph is neither a historical outline of the development of the concepts of protein biosynthesis and the structure and functions of the ribosomes, nor an exhaustive survey of the literature on these questions.