Bücher der Reihe Neuromethods

World-renowned researchers outline behavioral approaches used in characterizing mood and anxiety-related behaviors in mice as well as commonly used behavioral assays to assess the potential antidepressant and anxiolytic efficacy of novel compounds.

This book provides readers with up-to-date information on the basic principles of molecular imaging and its major applications in clinical neuroscience. It includes key tips and expert guidance to ensure successful research results.

This exploration of topics from immunohistochemistry for multiple neurochemicals covers a range of vital techniques from detecting expression levels of neurochemicals, to identifying polysynaptic pathways and recognizing functional changes in vivo.

Organized in sections on Physiology and Behavior, this Neuromethods series volume explores ideas and concepts behind the methods, tools, and tricks currently being utilized to decode the secrets of the brain of the small fruit fly, drosophila melanogaster.

Divided into two convenient sections, Protein Kinase Technologies collects contributions from experts in the field examining recent methodologies and techniques generally applicable to protein kinase research as well as to individual protein kinases which require special attention in neuroscience.

Zebrafish (Danio rerio) play an integral role in biomedical research, enabling researchers to examine physiological mechanisms and pathways relevant to human pathogenesis and its therapy.

This volume highlights proteomics studies of quantitative PTM changes in both peripheral and central nervous system proteomes utilizing the most recent advances in mass spectrometry. Chapters include practical information pertaining to the fundamentals of sample preparation, liquid chromatography, and tandem mass spectrometry instrumental analysis and will elucidate best practices in the interpretation of data using modern bioinformatics approaches. Written for the popular Neuromethods series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory.Authoritative and practical, Analysis of Post-Translational Modifications and Proteolysis in Neuroscience aims to ensure successful results in the further study of this vital field.

This volume details methods for the analyses of specific lipid classes and lipidomics analyses of cells such as lymphocytes and oocytes.

Neurovascular Coupling Methods brings the reader up to date with the current state-of-the-art techniques in measuring blood flow in the brain, with chapters describing different techniques or combinations of techniques, applied to specific species in either healthy or abnormal brains.

Synapses underlie rapid and flexible neural communication in the brain and they hold the key to understanding higher brain functions in health and disease. The proposed volume brings together leading researchers to review these exciting new techniques and their application in neurobiological research.

Neurovascular Coupling Methods brings the reader up to date with the current state-of-the-art techniques in measuring blood flow in the brain, with chapters describing different techniques or combinations of techniques, applied to specific species in either healthy or abnormal brains.

Synapses underlie rapid and flexible neural communication in the brain and they hold the key to understanding higher brain functions in health and disease. The proposed volume brings together leading researchers to review these exciting new techniques and their application in neurobiological research.

Written for the popular Neuromethods series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory. Authoritative and practical, Neurotransmitter Transporters: Investigative Methods aims to ensure successful results in thefurther study of this vital field.

Calcium Measurement Methods provides a comprehensive overview of calcium imaging techniques for the nervous system. A detailed account of calcium indicators are presented, in addition to a wide array of methods aimed at real-time calcium imaging.

Transcranial Magnetic Stimulation seeks to enable new and existing practitioners to learn and follow established TMS protocols.

This Neuromethods series book reviews methods for generating lesions and for stimulating and inhibiting neural pathways, covering new techniques such as optogenetics and the use of the in situ perfused preparation and reassessing well-known approaches.

Societal, ethical, and cost-related issues, not to mention the need for sound scientific methods, have led to new and refined methods for the evaluation of health risks associated with neurotoxic compounds, relevant and predictive of exposure, relatively inexpensive, and ideally amenable to high throughput analysis and a reduction in animal use.

Calcium Measurement Methods provides a comprehensive overview of calcium imaging techniques for the nervous system. A detailed account of calcium indicators are presented, in addition to a wide array of methods aimed at real-time calcium imaging.

Applying neurophysiological methods to the study of brain-behavior relationships proved to be a major advance in the early days of neuroscience research.

Epigenetic Methods in Neuroscience Research guides readers through methods for the analyses of chromatin remodeling, transposable elements, non-coding RNAs, such as miRNAs, and circadian oscillations, including: analysis of DNA methylation in neuronal and glial cells or small tissue samples;

Retinal diseases are among the leading causes of irreversible visual impairment and blindness. This vital book provides an easily accessible and authoritative reference for animal models of the most common and important retinal diseases.

World-renowned researchers outline behavioral approaches used in characterizing mood and anxiety-related behaviors in mice as well as commonly used behavioral assays to assess the potential antidepressant and anxiolytic efficacy of novel compounds.

The two Animal Models in Psychiatry volumes are loosely organized by subject. The second volume deals with affective and anxiety disorders, but also includes chapters on subjects not easily classified as either psychotic, or affective, or an- ety-related, such as aggression, mental retardation, and memory disorders.

Zebrafish (Danio rerio) play an integral role in biomedical research, enabling researchers to examine physiological mechanisms and pathways relevant to human pathogenesis and its therapy.

Preclinical research related to mood and anxiety disorders relies extensively upon mouse behavioral tests and models, the use of which continues to increase as a greater number of underlying susceptibility genes are discovered, new targets for medications are identified, and clinical studies reveal novel neurobiological risk factors.

Receptor and Ion Channel Detection in the Brain provides state-of-the-art and up-to-date methodological information on molecular, neuroanatomical and functional techniques that are currently used to study neurotransmitter receptors and ion channels in the brain.

This volume provides in-depth descriptions and discussion of clinical trial designs based on novel data analysis of high-quality trials for 11 different neurological conditions in order to ultimately improve the quality of care in neurology.

This arrangement is based on what are ostensibly increasing levels of integrated activity of the nervous system and, therefore, increasing levels of behavioral integration.