Bücher der Reihe Oxidative Stress and Disease

Covers antioxidants in beverages and herbal products, nitric oxide and selenium. This book highlights research on food-derived antioxidants and biomarkers; vitamins E and C; coenzyme Q; carotenoids, flavoroids and other polyphenols; antioxidants in beverages and herbal products; and, the thiol antioxidants glutathione and lipoic acid.

Responding to the increased popularity of herbal medicines and other forms of complementary or alternative medicine world-wide, this reference reviews and evaluates various safety, toxicity, and quality-control issues related to the use of traditional and herbal products for health maintenance and disease prevention and treatment. With over 3,550 references, the book highlights the role of herbal medicine in national healthcare and provides case studies of widely used herbal remedies, their effects on human health and wellness, and the need for methodologically sound clinical trials for herbal medicines.

Flavonoids exert a multiplicity of biological effects on humans and can have beneficial implications for numerous disease states. This volume examines current knowledge regarding the absorption, metabolism, and bioavailability of individual flavonoids and related phenolic compounds. Edited by internationally recognized leaders in the field, the book presents contributions by a panel of experts who demonstrate the potential of flavonoids in ameliorating a range of disease states, including cardiovascular disease, Alzheimer¿s and Parkinson¿s disease and other neurodegenerative disorders, and cancer. This research provides a reliable starting point for further inquiry and experimentation.

Vitamin C holds a unique place in scientific and cultural history. This book surveys this history also provides updates on recent uses of Vitamin C in cancer therapy, the treatment of infectious disease, and the potential for stem cell transplantation, as well as other health implications.

Obesity leads to a host of pathologies, including cardiovascular disease, insulin resistance, and metabolic syndrome. This book focuses on the effects of obesity on systemic inflammation. It addresses the epidemiology of obesity-induced inflammation and the adipokine mediators that link adipose tissue to inflammation.

Flavonoids exert a multiplicity of biological effects on humans and can have beneficial implications for numerous disease states. This volume examines current knowledge regarding the absorption, metabolism, and bioavailability of individual flavonoids and related phenolic compounds. Edited by internationally recognized leaders in the field, the book presents contributions by a panel of experts who demonstrate the potential of flavonoids in ameliorating a range of disease states, including cardiovascular disease, Alzheimer¿s and Parkinson¿s disease and other neurodegenerative disorders, and cancer. This research provides a reliable starting point for further inquiry and experimentation.

Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. This volume examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis. Topics include electron transport and energy production, mitochondrial biogenesis and dynamics, mitochondrial signaling, and apoptosis and autophagy. The book also explores pharmacology signaling and epigenetic signaling, with discussions on mitochondrial methylation and acetylation reactions. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.

There is now a large amount of data available for human beings, showing health beneficial hormetic effects of mild stresses from physical, chemical, nutritional, and mental sources. However, these data are dispersed in the literature and not always interpreted as hormetic effects, thus restricting their full apprehension and application. A comprehensive discussion of the research, this book is composed of four sections: (I) History and Terminology, (II) Evidence for Hormesis in Human Beings, (III) Molecular Mechanisms of Hormesis, and (IV) Hormesis in Risk Assessment.

An essential resource for scientists and researchers of nutrition, aging, and metabolic diseases, this book highlights the interactions among nutrients, epigenetics, and health. It presents new information on the action of diet and nutritional determinants in regulating the epigenetic control of gene expression in health and disease. Each chapter gives a unique perspective on a different nutritional or dietary component or group of components, and reveals novel mechanisms by which dietary factors modulate the epigenome and affect development processes, chronic disease, and the aging process.

Even before oxygen appeared in our athmosphere, redox reactions provided the energy for metabolic steps in the evolution of life. Redox modifications are now important in cellular functions including differentiation/development. This book compiles current knowledge regarding the roles of redox regulation in differentiation and de-differentiation.

The brain is crucial for the regulation of whole-body metabolism and behavior. The pancreas-derived hormone insulin modulates brain function and affects energy metabolism as well as cognition. This is partially achieved by modulating several types of brain cell populations including those relevant to satiety and reward. Importantly, brains of Alzheimer's disease patients exhibit a signature of brain insulin resistance with perturbed brain metabolism. This book will cover the basics of insulin signaling in the brain and will describe concepts of insulin resistance, a feature of type 2 diabetes. Moreover insulin's effect on cognitive function will be pointed out and the association between brain insulin resistance and neurodegenerative diseases discussed. Additionally, potential behavioral and pharmacological concepts which can affect brain insulin signaling will be summarized.Key Features:Summarizes insulin and the closely related IGF-1 receptor signaling Depicts concepts of insulin resistance Highlights the importance of conserved brain insulin signaling for brain function, metabolism, and behaviorDescribes potential behavioral and pharmacological approaches to support brain insulin signaling