Bücher der Reihe Recent Results in Cancer Research

Data have been presented on 261 cases in which multiple carcinomas of the colon were seen at the Mayo Clinic from January 1, 1944, through December 31, 1953. When the diagnosis of a malignant lesion of the colon or rectum has been made, the entire large bowel must be considered a potential source of malignant disease.

The main topics discussed are: changes of metabolism and microcirculation under heat conditions, the biological interaction of heat with X-rays and several chemotherapeutic agents, and the most recent clinical data from different institutions on the combined application in the treatment of cancer.

Seventeen years ago Mr. HAYWARD came to work in the Breast Clinic at Guy's Hospital.

Symposium on Malignant Transformation by Viruses, the University of Chicago School of Medicine, February 26th and 27th, 1966

Gastrointestinal lymphomas have attracted increasing interest over the past few years and are a topic characterized by intensive and ongoing activity. Experts from all over the world came together to exchange their experiences and to discuss new concepts at an international symposium in Wurzburg, Germany, in 1998.

The second international symposium on "Supportive Care in Cancer Patients" took place March 1-3, 1990-again in St. Gallen in eastern Switzerland.

Yet infection remains the leading cause of death in cancer patients and is a major cause of morbidity and hospitaliza tion, making it a major aspect of the supportive care of cancer patients.

In 1971, a breakthrough was achieved with the isolation, structural analysis, and synthesis of the luteinizing hormone releasing hormone (LH-RH), or GnRH as it is now more appropriately termed, since it provokes the secretion of both gonadotropins, LH and FSH, and since then the progress made in this area of research has been remarkable.

This important book provides up-to-date information on a series of topical issues relating to the approach to minimal residual disease in breast cancer patients. It first explains how the study of minimal residual disease and circulating and disseminated tumor cells (CTCs/DTCs) can assist in the understanding of breast cancer metastasis.

Prostate cancer is by far the most common cancer in men and the second leading cause of death due to cancer. Prevention of prostate cancer and discrimination between aggressive and indolent forms are important clinical goals and the acquisition of significant new evidence on means of achieving these aims makes this book particularly timely.

The 1969 Proceedings of the Plenary Session of the European Organization for Research on Treatment of Cancer have been divided between two volumes of a com pletely different nature.

Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors.

Symposium, University of Chicago Pritzker School of Medicine, March 1972

Die ersten erfolgreichen Versuche zur Züchtung tierischer Zellen außerhalb des Organismus reichen zurück in den Beginn unseres Jahrhunderts. 1907 gelang HARRI­ SON durch Explantation von Gewebsstücken aus Froschembryonen der Nachweis, daß in der Embryonalentwicklung die Neuriten als Fortsätze der Nervenzelle ohne Be­ teiligung anderer Zellen gebildet werden, und daß damit eine spezifische celluläre Funktion auch außerhalb des Gesamtorganismus zu beobachten ist [310,311]. Außer­ dem konnte CARREL 1912 zeigen, daß es bei Verwendung einer geeigneten Nährlö­ sung und deren regelmäßiger Erneuerung möglich ist, Kulturen tierischer Gewebe beliebig lange im Zustand aktiver Proliferation und Zellvermehrung zu erhalten [76]. Die Methodik CARRELS war derjenigen von HARRISON recht ähnlich: in bei den Fällen wurden die Kulturen durch Einbettung eines kleinen Gewebsstückes in ein Gel - im einen Fall bestehend aus einer Mischung von Blutplasma und Embryo­ extrakt, im anderen aus Froschlymphe - hergestellt. In der Zielsetzung jedoch unter­ scheiden sich die beschriebenen Versuche voneinander in grundsätzlicher Weise. HARRISON ging es um die Untersuchung einer spezifischen Funktion unter Bedingun­ gen in vitro, während CARRELS Bemühungen auf die unbeschränkte Fortsetzung der Zellvermehrung außerhalb des Gesamtorganismus ausgerichtet waren. Es zeigte sich schon bald, daß im allgemeinen Zellfunktion und Zell vermehrung in vitro gewissermaßen antagonistische Prozesse darstellen. Nach Explantation eines Gewebsstückes in einem Plasma-Gel läßt sich nämlich nach kurzer Zeit eine zuneh­ mende Desorganisation, vor allem an den Rändern des Gewebsstückes, durch Zell­ auswanderung und Zellteilung beobachten [520]. Mit dem Verlust der spezifischen Strukturgeht dann meist auch ein Verlust der typischen Zellfunktionen einher.

It should give the reader up to date information on the indications for clinical lymphography and its interpretation, thereby de monstrating the limits of its diagnostic accuracy and stressing the great impor tance of the method for the evaluation of cancer patients.

Symposium on Normal and Malignant Cell Growth, The University of Chicago School of Medicine, February 24th and 25th, 1968

Over the past 50 years many in vitro and in vivo drug response assay systems have been developed to determine the potential - tivity of chemotherapy agents.

Although pancreatic cancer is one of the most serious forms of cancers, the lack of clinical symptoms often limits curative treatment options. This book gives insight into the current understanding of the management of pancreatic cancer and considers recent findings in cancer research.

The identification of novel mediators and targeting molecules has led to significant progress in our understanding of tumor angiogenesis and tumor vessel targeting. Important advances in cancer treatment have already emerged, and in the future, blood vessel targeting will play a significant role within individualized therapeutic strategies.

This textbook, written by acknowledged experts, provides a broad overview of the small molecules currently used for the treatment of malignant diseases and discusses interesting novel compounds that are in the process of clinical development to combat cancer.

Detailed attention is also paid to other important recent developments, including molecular response prediction, early metabolic response evaluation by PET and PET-CT, the diagnosis of micrometastases, and the use of sentinel node technology.

This book explores in depth the relation between physical activity and cancer control, including primary prevention, coping with treatments, recovery after treatments, long-term survivorship, secondary prevention, and survival.

Malignant mesothelioma is an aggressive and fatal neoplasm of serous membranes that still shows a rising incidence worldwide. This book covers all the important aspects of the disease by bringing together contributions from selected experts in the fields of epidemiology, imaging, pathological diagnosis, therapy, genetics, and screening.

The principal focus, however, is on therapy, with detailed information on the various promising treatment options which give hope that this cancer will be transformed into a chronic disease or even become curable.

The surgical resection of a major portion of the liver for cancer of this viscus has long been neglected.

In fact, the same product was discovered in the same year, though quite independently, by a group of French workers [184] who described it under the name of rubidomycin, and by a group of Italian workers [87] who studied it under the name of daunomycin.