Bücher der Reihe Respiratory Pharmacology and Pharmacotherapy

Focussed specifically on children and pediatric respiratory diseases, "The Pediatric Lung+" reviews the current status of pharmacological therapy for asthma, viral pneumonia, cystic fibrosis, bronchopulmonary dysplasia and acute respiratory failure. A review of aerosol delivery systems in children and an up-to-date treatise on mucolytic agents is also included. The chapters are written by leading specialists in the field and summarize the latest developments in pediatric pulmonology, as well as covering a comprehensive range of respiratory diseases in children. Pediatric pulmonologists, allergologists, intensivists, neonatologists and general pediatricians will find "The Pediatric Lung" an invaluable source of reference. Clinicians will be particularly interested in the new information concerning aerosol delivery systems, gene therapy for cystic fibrosis, new modalities of therapy for asthma, the emerging role of nitric oxide and a treatise on modern mycolytic agents.

Conceptually unsavoury, airway mucus is vital to homeostasis in the respiratory tract. The volume concludes with a discussion of the therapeutic aspects of the topic, both in terms of the possible approaches to the treatment of mucus hypersecretion and the interaction of these drugs with airway mucus.

Conceptually unsavoury, airway mucus is vital to homeostasis in the respiratory tract. The volume concludes with a discussion of the therapeutic aspects of the topic, both in terms of the possible approaches to the treatment of mucus hypersecretion and the interaction of these drugs with airway mucus.

The biology of the family of endogenous autocrine peptides known as the endothelins (ETs) has been a source of intense study for researchers since 1988, following the identification of ET-l as the previously described endothelium-derived contractile factor.

Lung cancer is a disease with pandemic public health implications as it is now the leading cause of cancer mortality throughout the world. The hope is that enough progress will occur to permit lung cancer detection in advance of clinical cancer so that the disease can be addressed early on, while it is still confined to the site of origin.

Many factors may influence the release of neurotransmitters from airway nerves [1]. There are marked differences be tween species in airway innervation and in neuromodulatory effects and, wherever possible, studies in human airways have been emphasised, although information on neuromodulation in human airways is some what limited at present.

Most studies on autonomic innervation of smooth muscle have focused on the short-term mechanisms involved in neurotransmission in physiological and pathophysiological conditions.

Continuing the Respiratory Pharmacology and Pharmacotherapy series, this volume explores the pathophysiology and therapy of rhinitis. The various causes and the types of rhinitis - such as allergic, vasomotor, and infectious - are discussed as are the treatments available (pharmacotherapy, immunotherapy, surgery).

3. 1.

In the following sections, we will discuss the role of various non-invasive or relatively non-invasive methods to assess airway inflammation in asthma and concentrate on the only direct method of induced sputum examination. In his textbook The Principles and Practice of Medicine, in 1892, Sir William Osler described "bronchial asthma .

Nitric oxide is an endogenously produced gas with a wide range of biological effects and has been implicated in many physiological and pathophysiological processes. The authors identify key areas in the history, biochemistry, physiology, pathophysiology, immunology and clinical applications of nitric oxide in the lung.

Building on the existing titles in the "Airways Smooth Muscle" sub-series, the sixth volume explores physiological and pharmacological processes in the lung in vivo. The various animal models available for studying the bronchospasm and inflammation associated with human asthma are thoroughly reviewed by internationally recognised scientists. Specific chapters focus on the problems of administering drugs to animal airways, the mechanics of assessing lung function in the models, and describe in detail the species used, from rodents to primates. The use of genetically altered animals, an area of particular interest to molecular biologists, is also considered in depth. This up-to-date and extensively referenced work will prove invaluable to pharmacologists, physiologists and other biological scientists at all levels in academia and in the pharmaceutical industry.

Infection of the lower respiratory tract is a major determinant of the course of cystic fibrosis.

Building on the existing titles in the "Airways Smooth Muscle" sub-series, the sixth volume explores physiological and pharmacological processes in the lung in vivo.

Continuing the Respiratory Pharmacology and Pharmacotherapy series, this volume explores the pathophysiology and therapy of rhinitis. The various causes and the types of rhinitis - such as allergic, vasomotor, and infectious - are discussed as are the treatments available (pharmacotherapy, immunotherapy, surgery).