Bücher der Reihe Serono Symposia USA

Furthermore, recent focus on a novel family of GH secretagogues that complement the action of GHRH has shown that in animal models, these compounds have the potential to restore GH secretion in deficient or insufficient states, including growth retardation, obesity, and aging.

The young investigator with an idea has to negotiate many institutional, federal, and industrial challenges in order to get a product to market. Nowhere is described the steps in the development of new drugs, diagnos- tics, or devices; the person with an idea has nowhere to turn for information and details. The young investigator may understand the elements of basic and clinical research, but ordinarily has no insight into novel ways of finding research funding or how to explore to find the funding opportunities that are available. The young investigator has little knowledge of the mecha- nisms to bring an idea through the developmental phases to the market. There are other players in this complex endeavor with whom he or she has no contact, including those from industry, the Food and Drug Administration, and the legal community. Exposure to the philosophy of product develop- ment and to procedural information would be useful to the scientific com- munity, as would contact with those who have successfully taken an idea to a finished product. A first attempt to do this was the symposium on Idea to Product: The Process, sponsored by Serono Symposia USA and held No- vember 17 to 20, 1994, in Washington, D.C. This book comprises the pro- ceedings of that meeting. The editors are indebted to the many contributors to this volume, and we are especially grateful to Serono Symposia USA and to Leslie Nies and her staff for their expertise in organizing the symposium.

Arguing against an essential role for GH in the reproductive process is the observation that individuals who have GH resistance of the Laron variety are fertile arid that isolated GH deficiency does not constitute an absolute barrier to the attainment of sexual maturation and fertility.

The work of Dr. Guillemin, who was awarded the 1977 Nobel Prize in Physiology and Medicine, supported the view that quantita tive change in GH secretion was the net result of pituitary stimulation and inhibition by the hypothalamic neurohormones, GH releasing hormone (GHRH), and somatostatin (somatotropin release inhibiting factor;

Proceedings of the XIIIth Testis Workshop on Cellular and Molecular Regulation of Testicular Cells sponsored by Serono Symposia USA, Inc., held March 30 to April 1, 1995, in Raleigh, North Carolina.

Proceedings of the International Symposium on Perimenopause, sponsored by Serono Symposia USA, Inc., held November 17 to 20. 1995, in Palm Beach Gardens, Florida.

Major nutrition-al factors, such as calcium and vitamin D, were reexamined, with special attention on the ef fects of calcium, given either as a supplement or in dairy products in chil dren and adolescents, and to vitamin D supplementation in the elderly.

This volume contains the proceedings of the XVth North American Testis Workshop, held in Louisville, Kentucky, April 7 to 10, 1999, to describe current advances in testis biology.

Proceedings of the Symposium on the Regulation and Actions of Follicle Stimulating Hormone, sponsored by Serono Symposia, USA, held October 25 to 28, 1990, in Evanston, Illinois

This volume contains the Proceedings of the Serono Symposium on Pre implantation Embryo Development, held in Newton, Massachusetts, in 1991. The idea for the symposium grew out of the 1989 Serono Symposium on Fertilization in Mammals* at which preimplantation development was the predominant suggestion for a follow-up topic.

Recent advances in molecular biology have provided new dimensions in the study of the reproductive system. Studies on the functional relevance of gonadotropin releasing hormone and LH and FSH gene expression were presented, together with research on the molecular biology of ovarian and testicular steroidogenic enzymes and protein hormones.

The term polycystic ovary syndrome (peOS) is meant to describe a clinical endocrinopathy characterized by menstrual irregularity and evidence of hyperandrogenism.

Over the last several decades, many biologists have been intrigued with the "immunological paradox" of pregnancy, where maternal and fetal tissues peaceably coexist despite their genetic differences.

Advances in the field of glycoprotein hormones necessitated a second international symposium on this topic, held March 11 to 14, 1993, in Santa Barbara, California, and again sponsored by Serono Symposia, USA.

Quality of the Body Cell Mass presents proceedings of the International Symposium on Quality of the Body Cell Mass held in Fort Lauderdale , Florida.

Sex-Steroid Interactions with Growth Hormone presents the proceedings of an international symposium held from October 22-25 in Naples, Florida. Chapters include discussions of the impact of sex steroids on growth hormone secretion in both children and adults; how sex steroids modulate growth hormone action on target issues;

Recent research suggests that adult growth hormone (GH) deficiency, whether of pathological or physiological origin, is associated with a dis tinct syndrome that includes alterations in body composition, endocrine metabolic function, immune competence, and physical and psychosocial well-being.

The regulation of cell death in various reproductive tissues, as in other ma jor organ systems of the body, has become a focal point of research activity in many laboratories over the past few years.

They discussed the mechanism and regulation of motility, the metabolic strategy of human spermatozoa, the effects of exogenous fac tors such as antibodies, infections, and toxins, and finally the role of intracel lular calcium on sperm motility.

The young investigator with an idea has to negotiate many institutional, federal, and industrial challenges in order to get a product to market.

The First Ovarian Workshop was held in June 1976; The Ovarian Workshops quickly became a major biennial event for the community of reproduc tive biologists and their students studying ovarian function. The Seventh Ovarian Workshop was held on the campus of the University of Puget Sound in Tacoma, Washington on July 31 and August 1, 1988.

During the last two decades, progress in steroid hormone research has resulted in the development of new approaches to contraception as well as diagnosis and treatment of endocrine disorders and cancers.

This 1987 ORPRC Symposium on Primate Reproductive Biology, the third in a series, marked the twenty-fifth anniversary of the Oregon Regional Primate Research Center (ORPRC).

In this era of proliferation of synthetic growth hormone in the marketplace, there is a parallel and accentuated interest in growth hormone in the scientific arena.

The aim of this symposium was to provide basic and clinical investigators with the latest information on the biology of wound healing and tissue repair. endogenous growth factors; clinical applications of growth hormone and IGF-1 therapy; and clinical applications of peptide growth factors.

Proceedings of the Ninth Ovarian Workshop on Ovarian Cell Interactions: Genes to Physiology, sponsored by Serono Symposia, USA, held July 9 to 11, 1992, in Chapel Hill, North Carolina

This volume contains the proceedings of the Symposium on Molecular and Cellular Aspects of Periimplantation Processes, held July 15 - 18, 1994, in Boston, Massachusetts.