Bücher der Reihe Springer Theses

This thesis describes the authors' pioneering efforts in the conceptualization and implementation of combined platinum-based immuno-chemotherapeutics, which represent a significant paradigm shift from the conventional approach of directly targeting cancer.

This thesis discusses the use of asymmetric organic catalysis for the direct enantioselective synthesis of complex chiral molecules, and by addressing the many aspects of both vinylogy and atropisomerism, it appeals to researchers and scholars interested in both areas.Organocatalysis is a relatively modern and ¿hot¿ topic in the chemical community; it is constantly expanding and its use has been extended to interesting areas like vinylogous reactivity and atropisomerism. Vinylogous systems are very important for their synthetic applications but also pose a number of challenges, the most notable of which are their reduced reactivity and the reduced stereocontrol at these positions. On the other hand, atropisomeric systems are even more important because of the huge potential they have as drugs, ligands and catalysts. Chemists have only recently ¿recognized¿ the importance of these two areas and are focusing their efforts on studying them and the challenges they pose. This thesis offers an extensive introduction on the general aspects of chirality and organocatalysis and an equally extensive experimental section that allow nonexperts to understand the discussion section and reproduce the experiments.

The book introduces novel Bayesian topic models for detection of events that are different from typical activities and a novel framework for change point detection for identifying sudden behavioural changes.Behaviour analysis and anomaly detection are key components of intelligent vision systems.

Combining experimental implementation with theoretical modelling, it investigates three classes of graphene nanostructure fabrication using particle beam irradiation: (i) doping of graphene using low energy nitrogen irradiation;

This thesis focuses on an unresolved problem in particle and nuclear physics: the relation between two important non-perturbative phenomena in quantum chromodynamics (QCD) - quark confinement and chiral symmetry breaking.

By optimizing the electrode materials, preparation process for the fuel cells, and nano-micro structure of the electrode, the resulting MS-SOFCs demonstrated (1) great output power densities at low temperatures, e.g., 1.02 W cm-2 at 600 DegreesC, when operating in humidified hydrogen fuels and air oxidants;

This thesis mainly describes the development of a screening process for a mirror-image library of chiral natural products. It demonstrates how, by using mirror-image proteins for the screening of available natural products, unavailable mirror-image isomers of natural products can be screened in a mirror process.

This book on space geodesy presents pioneering geometrical approaches in the modelling of satellite orbits and gravity field of the Earth, based on the gravity field missions CHAMP, GRACE and GOCE in the LEO orbit.

This thesis offers a unique guide to the development and application of ultrasensitive optical microscopy based on light scattering.

This thesis investigates the tribological viability of bio-based base stock to which different nanoparticles were incorporated for engine piston-ring-cylinder-liner interaction.

In particular, it investigates the unique effects of metal ions like Mg2+, Al3+ and Fe3+ that are inherent in clays (smectite) on the combustion and thermo-oxidative decomposition of polyamide 6.

This thesis examines electrode materials such as mesoporous carbons, manganese oxides, iron oxides and their nanohybrids with graphene.

This thesis provides an innovative strategy for rail crack monitoring using the acoustic emission (AE) technique.

This thesis proposes a reliable and repeatable method for implementing Spoof Surface Plasmon (SSP) modes in the design of various circuit components.

This book studies the dynamics of fundamental collective excitations in quantum materials, focusing on the use of state-of-the-art ultrafast broadband optical spectroscopy.

This thesis presents an important step towards a deeper understanding of naturally fractured carbonate reservoirs (NFCRs). It demonstrates the various kinds of discontinuities using geological evidence, mathematical kinematics model and computed tomography and uses this as a basis for proposing a new classification for NFCRs. Additionally, this study takes advantage of rock mechanics theory to illustrate how natural fractures can collapse due to fluid flow and pressure changes in the fractured media.The explanations and mathematical modeling developed in this dissertation can be used as diagnostic tools to predict fluid velocity, fluid flow, tectonic fracture collapse, pressure behavior during reservoir depleting, considering stress-sensitive and non-stress-sensitive, with nonlinear terms in the diffusivity equation applied to NFCRs. Furthermore, the book presents the description of real reservoirs with their field data as the principal goal in the mathematical description of the realistic phenomenology of NFCRs.

Due to the ubiquity of heterocycles in bioactive natural products and life-improving pharmaceutical treatments, a long-term goal for synthetic organic chemists has been to develop novel and creative heterocycle syntheses that illicit a high degree of product diversity and are characterized by mild reaction conditions and limited waste production.

This book offers a clearly written and highly accessible account of two different aspects of carbohydrate chemistry. Carbohydrates are an essential component of life and have many important biological functions, but the details of how carbohydrates interact with other biomolecules to mediate biological signalling remain unclear. Firstly, this thesis details innovative methods to mine protein structural data to uncover new features of carbohydrate-based interactions. It also explains these findings using physical chemistry, specifically CH-pi interactions associated with the properties of the interacting partners. Carbohydrates are also critical for tissue growth and development, yet are underexploited in the materials science that underpins much of regenerative medicine. As such, the second part of this thesis describes a diverse array of techniques ranging from synthetic chemistry and enzymatic synthesis to prepare a wide variety of carbohydrates, and materials chemistry to prepare glycosylated hydrogels, to cell biology to determine the effects on cellular development for tissue engineering applications.

This book focuses on the analytical modeling of fractional-slot concentrated-wound (FSCW) interior permanent magnet (IPM) machines and establishes a basis for their magnetic and electrical analysis.

In this book, the molecular recognition of DNA using small molecules is discussed, with a study of the photochemistry of BrU-labeled DNA.

This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery.

This thesis focuses on the growth of a new type of two-dimensional (2D) material known as hexagonal boron nitride (h-BN) using chemical vapor deposition (CVD). This came as a major surprise to many working in the 2D field, as it had been generally assumed that hexagonal-shaped h-BN was impossible due to energy dynamics.

This book describes the application of a novel technology for beam instrumentation and luminosity measurement and first results on a cutting edge technology potentially to be used after the upgrade of the Large Hadron Collider to higher luminosity.It presents a unique diamond-based luminometer with a detailed performance study.The online bunch-by-bunch luminosity measurements provide an invaluable feedback to the Collider for beam optimisation and for the understanding of beam dynamics.The precision of the luminosity measurement is crucial for all physics analyses. This book highlights the Van der Meer method, which is used for the calibration of the luminometers of the CMS (Compact Muon Solenoid) experiment, and describes the estimate of systematic uncertainties, e.g. due to radiation damage of sensors and electronics and uncertainties of beam parameters.For the future high-luminosity upgrade of the collider, sapphire sensors are investigated in a test beam. It is demonstrated for the first time that sapphire sensors can be used as single particle detectors. A model for the charge transport in sapphire is developed and successfully applied.

This book introduces a variety of statistical tools for characterising and designing the dynamical features of complex quantum systems. In dynamical quantum systems, complexity typically manifests itself via the interference of a rapidly growing number of paths that connect the initial and final states.

This thesis advances the long-standing challenge of measuring oxidative stress and deciphering its underlying mechanisms, and also outlines the advantages and limitations of existing design strategies. It presents a range of approaches for the chemical synthesis of fluorescent probes that detect reversible changes in cellular oxidative stress. The ability to visualise cellular processes in real-time is crucial to understanding disease development and streamline treatment, and this can be achieved using fluorescent tools that can sense reversible disturbances in cellular environments during pathogenesis. The perturbations in cellular redox state are of particular current interest in medical research, since oxidative stress is implicated in the pathogenesis of a number of diseases.The book investigates different strategies used to achieve ratiometric fluorescence output of the reversible redox probes, which nullify concentration effects associated with intensity-based probes. It also describes suitable approaches to target these probes to specific cellular organelles, thereby enabling medical researchers to visualise sub-cellular oxidative stress levels, and addressing the typically poor uptake of chemical tools into biological studies. In total it reports on four new probes that are now being used by over twenty research groups around the globe, and two of which have been commercialised. The final chapters of this thesis demonstrate successful applications of the sensors in a variety of biological systems ranging from prokaryotes to mammalian cells and whole organisms. The results described clearly indicate the immense value of collaborative, cross-disciplinary research.

The successes of the standard models of particle physics and cosmology are many, but have proven incapable of explaining all the phenomena that we observe.

This book details groundbreaking experiments for the sensing and imaging of terahertz-frequency electromagnetic radiation (THz) using Rydberg atoms. The major advances described include the development and implementation of a new technique for THz imaging using atomic fluorescence;

Starting from a broad overview of heat transport based on the Boltzmann Transport Equation, this book presents a comprehensive analysis of heat transport in bulk and nanomaterials based on a kinetic-collective model (KCM).

This book discusses searches for Dark Matter at the CERN's LHC, the world's most powerful accelerator. It introduces the relevant theoretical framework and includes an in-depth discussion of the Effective Field Theory approach to Dark Matter production and its validity, as well as an overview of the formalism of Simplified Dark Matter models. Despite overwhelming astrophysical evidence for Dark Matter and numerous experimental efforts to detect it, the nature of Dark Matter still remains a mystery and has become one of the hottest research topics in fundamental physics.Two searches for Dark Matter are presented, performed on data collected with the ATLAS experiment. They analyze missing-energy final states with a jet or with top quarks. The analyses are explained in detail, and the outcomes and their interpretations are discussed, also in view of the precedent analysis of theoretical approaches. Given its depth of coverage, the book represents an excellent reference guide for all physicists interested in understanding the theoretical and experimental considerations relevant to Dark Matter searches at the LHC.

This book investigates the common nature of granular and active systems, which is rooted in their intrinsic out-of-equilibrium behavior, with the aim of finding minimal models able to reproduce and predict the complex collective behavior observed in experiments and simulations.