Bücher der Reihe Studies in Mechanobiology, Tissue Engineering and Biomaterials

Pressure-related chronic wounds are an important health concern that affects millions of patients and accumulates billions in annual costs. The results allow a complete picture of the tolerance of human tissues to sustained loads, and an understanding of the risk for onset of chronic wounds.

This book provides an overview of various drug delivery systems at the cellular level including biological, chemical methods, and most importantly physical methods such as photoporation, electroporation, mechanoporation, and device-based techniques (e.g., microfluidics), as well as organism-level techniques including nanomaterials, biomaterials, and transdermal. Drug delivery (DD) can be defined as the method and route by which an active pharmaceutical ingredient (API) is administered to promote its desired pharmacological effect and/or convenience and/or to reduce adverse effects. Drug delivery systems are developed to maximize drug efficacy and minimize side effects. As drug delivery technologies improve, the drug becomes safer and more comfortable for patients to use. During the last seven decades, extraordinary progress has been made in drug delivery technologies, such as systems for long-term delivery for months and years, localized delivery, and targeted delivery. The advances, however, will face the next phase considering the future technologies that we need to overcome many physicochemical barriers for new formulation development and biological unknowns for treating various diseases. Thus, various technologies are built at a single-cell level as well as an organism level. This book is useful at the university level for graduate courses or research studies and biotechnology-based companies with research and development on cell-based analysis, diagnosis, or drug screening. This book is also very useful for researchers in drug delivery technologies, which came in frontier research for the past decade.

Seven well-known scientists working in that particular field discuss topics such as biomolecules, networks and cells as well as failure, multi-scale, agent-based, bio-chemo-mechanical and finite element models appropriate for computational analysis.

Thisbook provides a state-of-the-art update, as well as perspectives on futuredirections of research and clinical applications in the implementation ofbiomechanical and biophysical experimental, theoretical and computationalmodels which are relevant to military medicine. Such experimental and modelingefforts are helpful, on the one hand, in understanding the aetiology,pathophysiology and dynamics of injury development and on the other hand inguiding the development of better equipment and protective gear or devices thatshould ultimately reduce the prevalence and incidence of injuries or lessentheir hazardous effects. The book is useful for military-oriented biomedicalengineers and medical physicists, as well as for military physiologists andother medical specialists who are interested in the science and technologyimplemented in modern investigations of military related injuries.

This book is intended for graduate students and researchers active in the field of computational modeling of biomedical processes who seek to acquaint themselves with the different ways in which to study the parameter space of their model as well as its overall behavior.

This book reviews the state-of-the-art in multiscale computer modeling, examining both its accomplishments and its challenges. Helps connect traditional biomedical engineering at the organ and tissue scale with cellular and molecular bioengineering.

The focus of this book is on mechanical aspects of skeletal fragility related to aging and osteoporosis. Topics include: Age-related changes in trabecular structure and strength; age-related changes in cortical material properties; age-related changes in whole-bone structure; age-related changes in skeletal mechano responsiveness;

This volume describes the state-of-knowledge in the study of the relationships between mechanical loading states in tissues and common pathophysiologies related to increase in mass of adipose tissues and/or hyperglycemia which eventually lead to obesity, diabetes, insulin resistance, hyperlipidemia, metabolic inflammations, certain types of cancer and other related diseases.There appears to be an interaction between the loading states in tissues and cells and these chronic conditions, as well as with factors such as age, gender and genetics of the individual. Bioengineering has made key contributions to this research field in providing technologies for cell biomechanics experimentation, microscopy and image processing, tissue engineering and multi-scale, multi-physics computational modeling. Topics at the frontier of this field of study include: the continuous monitoring of cell growth, proliferation and differentiation in response to mechanical factors such as stiffness of the extracellular matrix (ECM) and mechanical loads transferred through the ECM; mechanically-activated signaling pathways and molecular mechanisms; effects of different loading regimes and mechanical environments on differentiation fates of mesenchymal stem cells (MSCs) into myogenic and osteogenic versus adipogenic lineages; the interactions between nutrition and mechanotransduction; cell morphology, focal adhesion patterns and cytoskeletal remodeling changes in adipogenesis; activation of receptors related to diabetes by mechanical forces; brown and white adipose plasticity and its regulation by mechanical factors.

Active implants are actually drug or protein-eluting implants that induce healing effects, in addition to their regular task, such as support. The drug-eluting implants will be described in terms of matrix formats and polymers, incorporated drugs and their release profiles from the implants, as well as implant functioning.

Active implants are actually drug or protein-eluting implants that induce healing effects, in addition to their regular task, such as support. The drug-eluting implants will be described in terms of matrix formats and polymers, incorporated drugs and their release profiles from the implants, as well as implant functioning.

This book reviews the frontier of research and clinical applications of Patient Specific Modeling, and provides a state-of-the-art update as well as perspectives on future directions in this exciting field.

This volume focuses on the biomechanical modeling of biological tissues in the context of Computer Assisted Surgery (CAS). This is particularly new since most of the soft tissues models already proposed concern Computer Assisted Planning, with a pre-operative use of the models.

In the area of vascular therapies, aspects covered relate to latest research in small-diameter tissue-regenerative vascular grafts, one of the greatest persisting challenges in cardiovascular therapies, stent grafts and endovascular stents for percutaneous arterial interventions.

Damage to the central nervous system resulting from pathological mechanical loading can occur as a result of trauma or disease.

Recent developments in stem cell biology have opened new directions in cell therapy.

This book reviews the state-of-the-art in multiscale computer modeling, examining both its accomplishments and its challenges. Helps connect traditional biomedical engineering at the organ and tissue scale with cellular and molecular bioengineering.

The contributors to this volume bring together a unique blend of expertise in experimental, computational and tissue biomechanics relating to aneurysm behavior and enable the reader to gain a fresh understanding of key factors influencing aneurysm behavior and treatment.

One of the major challenges in tissue engineering is the translation of biological knowledge on complex cell and tissue behavior into a predictive and robust engineering process.

This book reviews the frontier of research and clinical applications of Patient Specific Modeling, and provides a state-of-the-art update as well as perspectives on future directions in this exciting field.

The focus of this book is on mechanical aspects of skeletal fragility related to aging and osteoporosis. Topics include: Age-related changes in trabecular structure and strength; age-related changes in cortical material properties; age-related changes in whole-bone structure; age-related changes in skeletal mechano responsiveness;

One of the major challenges in tissue engineering is the translation of biological knowledge on complex cell and tissue behavior into a predictive and robust engineering process.

Damage to the central nervous system resulting from pathological mechanical loading can occur as a result of trauma or disease.

This volume focuses on the biomechanical modeling of biological tissues in the context of Computer Assisted Surgery (CAS). This is particularly new since most of the soft tissues models already proposed concern Computer Assisted Planning, with a pre-operative use of the models.

This book presents regenerative strategies for the treatment of knee joint disabilities. The book is composed of four main sections totaling 19 chapters which review the current knowledge on the clinical management and preclinical regenerative strategies.

This volume describes and discusses recent advances in angiogenesis research. Angiogenesis experts from diverse fields including engineering, cell and developmental biology, chemistry and physics will be invited to contribute chapters which focus on the mechanical and chemical signals which affect and promote angiogenesis.

The contributors to this volume bring together a unique blend of expertise in experimental, computational and tissue biomechanics relating to aneurysm behavior and enable the reader to gain a fresh understanding of key factors influencing aneurysm behavior and treatment.

Many different cell types have been suggested for cell therapy in the framework of MTE, including autologous bone marrow-derived or cardiac progenitors, as well as embryonic or induced pluripotent stem cells, each having their particular advantages and disadvantages.

This volume describes and discusses recent advances in angiogenesis research. Angiogenesis experts from diverse fields including engineering, cell and developmental biology, chemistry and physics will be invited to contribute chapters which focus on the mechanical and chemical signals which affect and promote angiogenesis.