Bücher der Reihe Topics in Bone Biology

The science of bone replacement has greatly advanced in recent decades, but replacing bone with bone tissue rather than with metallic components remains in early development. The current volume, third in the series Topics in Bone Biology, deals with problems inherent in inducing the body cells to accomplish bone tissue repair, to degrade devices introduced to provide initial mechanical support, and to attract and stimulate bone f- mation. It is therefore logical that Chapter 1, by Hicok and Hedrick, deals with stem cells, i. e. , pluripotential cells that may differentiate into cartilage and bone cells. The chapter begins with a description of how stem cells may be harvested; the limitations of autologous, embryonic, and adult stem cells; and the need to expand the harvested cells in culture. The authors then discuss the in? uences of the body environment on implanted cells and on the scaffolds that need to be introduced. They emphasize the need for adequate oxygenation and for rapid integration with the vascular system of the host/patient. Stem-cell-engineered cartilage is discussed at some length, along with the need for stem-cell-engineered ligaments and tendons. The chapter concludes with an analysis of what needs to be learned to make stem-cell-engineered bone tissue a reality. In Chapter 2, Gerstenfeld and colleagues review osteogenic growth factors and cytokines, soluble proteins that regulate postnatal bone repair. These molecules are of importance because many are targets of efforts to promote therapeutic bone healing and repair.

Recent research, which Bone- Metabolic Function and Modulators expands on, has added new support to the idea that bone not only serves as a support system, but also functions as an integrating organ, with a significant regulatory role for lipid and energy metabolism. Links between physical activity and the skeleton are also becoming increasingly clear. This fully illustrated volume contains up-to-date information on the metabolic role of the skeleton and what this can mean for the treatment of metabolic as well as skeletal and auditory diseases. Bone- Metabolic Function and Modulators is of particular interest to clinician scientists, clinical and basic bone researchers, orthopedists, endocrinologists, internists, dentists, nurse practitioners, medical and dental residents and physiotherapists as well as students of the musculoskeletal system.Bone- Metabolic Function and Modulators is the seventh volume in the series Topics in Bone Biology, edited by Felix Bronner and Mary C. Farach-Carson.Other titles in this series:-Bone FormationBone Resorption Engineering of Functional Skeletal TissuesBone and OsteoarthritisBone and CancerBone and DevelopmentBone- Metabolic Function and Modulators is of particular interest to clinician scientists, clinical and basic bone researchers, orthopedists, endocrinologists, internists, dentists, nurse practitioners, medical and dental residents and physiotherapists as well as students of the musculoskeletal system.Bone- Metabolic Function and Modulators is the seventh volume in the series Topics in Bone Biology, edited by Felix Bronner and Mary C. Farach-Carson.Other titles in this series:-Bone FormationBone Resorption Engineering of Functional Skeletal TissuesBone and OsteoarthritisBone and CancerBone and DevelopmentBone- Metabolic Function andModulators is of particular interest to clinician scientists, clinical and basic bone researchers, orthopedists, endocrinologists, internists, dentists, nurse practitioners, medical and dental residents and physiotherapists as well as students of the musculoskeletal system.Bone- Metabolic Function and Modulators is the seventh volume in the series Topics in Bone Biology, edited by Felix Bronner and Mary C. Farach-Carson.Other titles in this series:-Bone FormationBone Resorption Engineering of Functional Skeletal TissuesBone and OsteoarthritisBone and CancerBone and Development

This is the 3rd volume in a series of reviews centered on the single major topic of bone replacement, discussing the biology of stem cells and cell signals, the knowledge needed to make stem cell-engineered bone tissue a reality, and how to prevent bone allograft infection.

Bone research in recent years has generated much new knowledge, in large measure because of the broad public health implications of osteoporosis and related bone disorders.

The molecular and cellular approaches to the relationship of joint and bone problems distinguish this from other books on the topic.

There is currently no single book with up to date information on osteoclast function and bone resorption. A useful collection of information, not readily available in a concentrated and convenient form on the market. Provides a comprehensive overview of the field.

The molecular and cellular approaches to the relationship of joint and bone problems distinguish this from other books on the topic.

This detailed treatment of the endocrine regulation of the skeleton and the disorders stemming from its dysfunction bridges the gap between research and practice. The authoritative coverage provides an overview of the topic as well as the latest knowledge.