Bücher der Reihe Topics in Current Chemistry

Introduction to Fragment-Based Drug Discovery, by Daniel A. Erlanson Fragment Screening Using X-Ray Crystallography, by Thomas G. Davies and Ian J. TickleHsp90 Inhibitors and Drugs from Fragment and Virtual Screening, by Stephen Roughley, Lisa Wright, Paul Brough, Andrew Massey and Roderick E. HubbardCombining NMR and X-ray Crystallography in Fragment-Based Drug Discovery: Discovery of Highly Potent and Selective BACE-1 Inhibitors, by Daniel F. Wyss, Yu-Sen Wang, Hugh L. Eaton, Corey Strickland, Johannes H. Voigt, Zhaoning Zhu and Andrew W. StamfordCombining Biophysical Screening and X-Ray Crystallography for Fragment-Based Drug Discovery, by Michael Hennig, Armin Ruf and Walter HuberTargeting Protein¿Protein Interactions and Fragment-Based Drug Discovery, by Eugene Valkov, Tim Sharpe, May Marsh, Sandra Greive and Marko HyvönenFragment Screening and HIV Therapeutics, by Joseph D. Bauman, Disha Patel and Eddy ArnoldFragment-Based Approaches and Computer-Aided Drug Discovery, by Didier Rognan

Over the last forty years,good old-fashioned colloid chemistry has undergone something of a revolution,transforming itself from little more than a collection of qualitative observations of the macroscopic behaviour of some complex s- tems into a discipline with a solid theoretical foundation and a whole toolbox of new chemical techniques.It can now boast a set of concepts which go a long way towards providing an understanding of the many strange and interesting beh- iour patterns exhibited by natural and artificial systems on the mesoscale. In other words: colloid chemists have acquired a great deal of experience in the generation and control of matter with tools that are specific on a scale of some nanometers to micrometers.Modern concepts such as self-organisation,hier- chical set-up of materials,nanoparticles,functional surface engineering,int- facing and cross-talk of complex chemical objects,all of which are now in the toolbox of this 90-year old science. It is the aim of the present issue of¿Topics in Current Chemistry¿to highlight some of the most attractive recent developments in colloid chemistry which are expected to have broader relevance and to be interesting to a more general readership.The contributions focus both on tools and procedures as well as on potential applications.

With contributions by numerous experts

Strong non-ionic bases are highly advantageous as stoichiometric reagents and as catalysts in synthetic organic chemistry owing to side reactions that f- quently occur when ionic bases such as LDA or alkali metal alkoxides are employed. A second reason that non-ionic bases are frequently more useful in these applications is that such bases are often more soluble in less polar organic solvents,particularly at low temperatures. Thirdly,non-ionic bases can provide reactive naked or tightly associated deprotonated substrate anions that are s- bilized by the relatively large,poorly solvated cations formed by the protonated base. In such cations,extensive positive charge delocalization can occur. Prior to our work on pro-azaphosphatranes of type 1 (Scheme 1),the very strong n- ionic bases utilized for organic transformations were largely confined to the nitrogenous bases shown below (Scheme 2). Scheme 1 Scheme 2 4 J. G. Verkade 2 Uses of Strong Nonionic Nitrogen Bases 2. 1 Amines One of the earliest strong non-ionic bases to make its appearance was Proton Sponge and its derivatives [1] and these systems have been reviewed [2]. More recently Proton Sponge has been used in the palladium-catalyzed arylation of 2,3-dihydrofuran [3], and it also catalyzes Knoevenagel condensations of s- strates possessing activated methylene groups [4]. Recently the synthesis of the macrocyclic tetramine below (Scheme 3) was reported [5]. The encrypted nitrogens are very basic (pK ,24.

With contributions by numerous experts

With contributions by numerous experts

Rose, and M. Monsan, and M. Development of Agriculture Left-Overs: Fine Organic Chemicals from Wheat Hemicellulose-Derived Pentoses, By F. Cellulose and Derivatives from Wood and Fibers as Renewable Sources of Raw-Materials, By J.A. Olive Pomace, a Source for Valuable Arabinan-Rich Pectic Polysaccharides,By M.

Knoevenagel Reaction of Unprotected Sugars, By M.-C.Carbohydrate-Based Lactones: Synthesis and Applications, By N. De Oliveira Vigier and F. Palladium-Catalyzed Telomerization of Butadiene with Polyols: From Mono to Polysaccharides, By S. Natural Sources, By L. Synthesis and Applications of Ionic Liquids Derived from Natural Sugars;

Time-dependent density functional response theory for electronic chiroptical properties of chiral molecules; by Yunjie Xu *Magneto-electric properties of self-assembled monolayers of chiral molecules; by Zeev Vager and Ron Naaman*Theory of adsorption induced chirality and electron transfer through chiral systems;

Genetics of Prion Disease, by S. Atypical Prion Diseases in Humans and Animals, by M. Molecular Dynamics as an Approach to Study Prion Protein Misfolding and the Effect of Pathogenic Mutations, by M.W. Chemical Biology of Prion Protein: Tools to Bridge the In Vitro/Vivo Interface, by R.

Next Generation Sequencing: Chemistry, Technology and Applications, by P. Wong Clinical Applications of the Latest Molecular Diagnostics in Noninvasive Prenatal Diagnosis, by K.C.A. Borchers Advances in MALDI Mass Spectrometry in Clinical Diagnostic Applications, by E.W.Y.

This will be a must-have work for scientists and practitioners in any field related to modern chemical research. It will also be highly useful for many workers in industry who are required to keep up-to-date with the latest news in chemistry and applied chemistry.

With contributions by numerous experts

K.N. Houk, D.J. Tantillo, C. Stanton, Y. Hu: What Has Theory and Crystallography Revealed About the Mechanism of Catalysis by Orotidine Monophosphate Decarboxylase?N. Wu, E.F. Pai: Crystallographic Studies of Native and Mutant Orotidine 5'Phosphate Decarboxylases; B.G.

With contributions by numerous experts

With contributions by numerous experts

This book is the second of two volumes that deal with discovery of chemical pathways of biosynthesis of natural products (secondary metabolites).

With contributions by numerous experts

This book is the second of two volumes that deal with discovery of chemical pathways of biosynthesis of natural products (secondary metabolites).

Molecular Cages and Capsules with Functionalized Inner Surfaces, by Stefan Kubik. Reversibly Expanded Encapsulation Complexes, by Dariush Ajami und Julius Rebek. Carina Schulze und Iris M. Molecular Capsules Derived from Resorcin[4]arenes by Metal-Coordination, by Tobias Schroeder, Satya Narayan Sahu und Jochen Mattay.