Bücher der Reihe Virology Monographs Die Virusforschung in Einzeldarstellungen

Since the clinical aspects of the diseases caused by herpes simplex virus and pseudorabies virus have been well described, greater emphasis will be placed, therefore, on the basic biological and biochemical properties of these viruses;

Introduction Of the ever increasing number of viruses known to affect man and higher animals, the virus of lymphocytic choriomeningitis (LCM) was one of the first to be discovered. Indeed, this virus has been known and maintained in the laboratory by passages in a relatively simple host, the mouse, for 35 years.

Immunological Response . . . . Thymectomy in LDV Infection . Ecology . Blood Samples from Mice for LDH Estimation . Estimation of Plasma LDH Activity . 101 a) Determination of Plasma LDH by Spectrophotometric Method (Backward Reaction) . 101 b) Determination of Plasma LDH by Spectrophotometric Method (Forward Reaction) . Units of LDH Activity .

, 1954) and in the same year the discovery of the double helical structure of DNA (WATSON and CRICK, 1953) and the plaque assay for one animal virus (DULBECCO and VOGT, 1953) was announced.

It was the experimental analysis of the multiplica tion behaviour which then revealed that the association between parvoviruses and tumors or parvoviruses and adenoviruses originates from the basis of a cer tain genetic defectiveness.

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Anamnestic Immune Responses in Sequential Infections With Dengue and Other Group B Togaviruses . . . . . . . . . . . . . . . . . . Along with other members of that group as well as group A, the dengue viruses have been investigated intensively during recent years.

Furthermore the 2 genomes of retroviruses originated from normal cell genes, genes called virogenes * The nucleic acid and protein probes isolated from these viruses are therefore useful for studying the nature and expression of this normal cell gene and in elucidating the physiological role of its products.

This volume, Biology of Poxviruses, marks our debut as editors of this well known series. But the pace of discovery is accelerating so rapidly that we feel the need to offer an additional format: volumes that contain collections of shorter, topical reviews on a group of related subjects.

Bluetongue may be described as an acute insect borne disease of ruminants, manifested clinically in sheep by a catarrhal inflammation of the mucous mem branes of the digestive and respiratory systems and associated with degenerative changes in the skeletal musculature.