Bücher veröffentlicht von Cold Spring Harbor Laboratory Press,U.S.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines our current understanding of all aspects of protein synthesis and its control. The contributors describe recent insights into the fundamental steps in translation (initiation, elongation, termination, and ribosome recycling) based on high-resolution structures of the translational machinery. The signaling pathways and targets of translational control (e.g., initiation factors, mRNAs, and ribosomes) are discussed, as are the roles of riboswitches, processing bodies (P-bodies), stress granules, and various classes of RNAs (e.g., circular RNAs). Methods to study translation dynamics, including ribosome profiling, kinetic assays, and single-molecule and single-cell fluorescence imaging, are also covered.

This is the third and completely revised edition of a now classic handbook that focuses specifically on management challenges faced by research scientists and technical professionals. In Lab Dynamics, Carl and Suzanne Cohen draw on their unparalleled professional experience (Carl as a scientist and Suzanne as a psychologist) and as workshop directors to provide invaluable, practical advice on how to succeed in science for working scientists and those in or preparing for management or leadership roles. The book is also required reading for anyone with an administrative role in the research enterprise who must understand that world and its complexities. Every chapter from the second edition has been revised, updated, and supplemented with new illustrations and graphics; many new case studies have been added to illustrate themes and techniques. Two new chapters have been added.

We learn and form memories by making changes to neurons and neuronal circuits in the brain. This book examines the molecular and cellular bases for these processes, as well as how memories are stored, maintained and retrieved.

Yeast genetics began with Winge's 1935 studies of S. cerevisiae in Copenhagen, and afterwards was pursued by Lindegren in the U.S. and Ephrussi in France. Genetic studies in S. pombe were pioneered by Leupold in the 1940s in Switzerland. Within four decades, not without controversies, both yeast species were recognized as essential models in eukaryotic molecular cell biology. In this remarkable volume, Hall and Linder have assembled the reminiscences of many early investigators whose pioneering studies in the years before 1975 brought yeast biology to its current maturity. These illustrated essays about the science, the events and the personalities involved capture a fascinating era, in the informal style made famous by Phage and the Origins of Molecular Biology. This is a book that all scientists interested in the development of modern genetics and molecular biology should have on their shelves.

Biology of Drosophila was first published by John Wiley and Sons in 1950. Until its appearance, no central, synthesized source of biological data on Drosophila melanogaster was available, despite the fly's importance to science for three decades. Ten years in the making, it was an immediate success and remained in print for two decades. However, original copies are now very hard to find. This facsimile edition makes available to the fly community once again its most enduring work of reference.

A collection of reprinted articles from the review journal Trends in Biochemical Sciences (TiBS) focusing on the central dogma of molecular biology?DNA makes RNA makes protein. The biographical and autobiographical articles graphically describe the great discoveries in the field from an insider's perspective.

Unavailable in the U.S. for many years, Horace Judson's remarkable lay history of molecular biology is now published in a new, expanded edition. The author has added new material on some of the principal figures involved, particularly Rosalind Franklin. Also included are a new Forward and an Afterword which sketches the further development of molecular biology into the era of recombinant DNA. No one active in current molecular genetics can fail to be informed and entertained by this extraordinary account of how it all began. Also highly recommended for students and interested lay people.