The book, Nanosensors for Futuristic Smart and Intelligent Healthcare Systems, presents a treatise on nanosensors technology including wearables, implantable devices and wireless tools. The recent pandemic (COVID-19) has changed the behaviour of people towards diagnosis of infectious diseases and monitoring remote patient health status in real-time. The main focus of this book is the basic concepts of nanomaterials and sensing paradigms for medical devices based on nanosensor technology. The book will be valuable to researchers, engineers and scientists interested in the field of healthcare for monitoring health status in real-time.
Food technology has adopted new principles and practices that are rapidly changing the food sector. New foods are now available under more uniform standards and better quality control. Globalised food market offers opportunities for manufacturers to increase production and profit, and at the same time, consumers benefit from the choice of food products like never before. All this is possible only because of the innovations in the food sector. One of such innovations is encapsulation technology, which aims to preserve food quality, enhance the sensorial properties of food and increase the efficiency in food processing. This book discusses the uses of encapsulation technology in food practices and conventional processes and also highlights new directions in food processing. In the introductory chapters' review of encapsulation technologies, carrier materials and criteria for their selection, analytical methods for characterisation of encapsulated products and some aspects of product design and process optimisation. The most important achievements of encapsulation technology in the food sector are reviewed in the later chapters related to encapsulation of food ingredients, food biocatalysts and examples of usage of encapsulated active ingredients in the dairy and meat industry, beverage production, etc. In addition, the implementation of nanotechnology in the food sector is reviewed, emphasizing the most important materials and technologies for the production of nanoencapsulates. The book is a valuable source of information on encapsulation technology, for academia and industry, especially the food sector, with the aim of enhancing knowledge transfer.
This book, Extremophiles: General and Plant Biomass Based Biorefinery, explores the potential of extremophiles in industries and biomass based biorefinery. The book sheds light on diversity and various applications of thermophiles, psychrophiles, halophiles, alkaliphiles and acidophiles for the production of value-added products including biofuels, extremozymes, etc. The chapters comprehensively emphasize the utility of extremophiles in sustainable biorefinery bioprocesses. This book is an integrated source of literature for scientists, engineers, academicians, and students working in the area of extremophiles, microbial technology and biorefinery.
Methodologies for Biosimilar Product Development covers the practical and challenging issues that are commonly encountered during the development, review, and approval of a proposed biosimilar product. These practical and challenging issues include, but are not limited to the mix-up use of interval hypotheses testing (i.e., the use of TOST) and confidence interval approach, a risk/benefit assessment for non-inferiority/similarity margin, PK/PD bridging studies with multiple references, the detection of possible reference product change over time, design and analysis of biosimilar switching studies, the assessment of sensitivity index for assessment of extrapolation across indications without collecting data from those indications not under study, and the feasibility and validation of non-medical switch post-approval.Key Features:Reviews withdrawn draft guidance on analytical similarity assessment.Evaluates various methods for analytical similarity evaluation based on FDA's current guidelines.Provides a general approach for the use of n-of-1 trial design for assessment of interchangeability.Discusses the feasibility and validity of the non-medical switch studies.Provides innovative thinking for detection of possible reference product change over time.This book embraces innovative thinking of design and analysis for biosimilar studies, which are required for review and approval of biosimilar regulatory submissions.
Carbon membranes have great advantages of strong mechanical strength and high chemical stabilities, as well as high separation performance to reach the industrial attractive region. Further improvement on membrane performance can potentially offset the relatively high production cost compared to polymeric membranes. However, there are still some challenges related to fabrication of asymmetric carbon membranes, the controlling of structure and pore-size and module up-scaling for commercial application. The aim of this book is to provide the fundamentals on carbon membrane materials for the young researchers and engineers to develop frontier membrane materials for energy efficient separation process.This book describes the status and perspectives of both self-supported and supported carbon membranes from fundamentals to applications. The key steps on the development of high performance carbon membranes including precursor selection, tuning carbon membrane structure and regeneration are discussed. In the end, different potential applications both in gas and liquids separation are well described, and the future directions for carbon membrane development were pointed out. To this end, membrane science and engineering are set to play crucial roles as enabling technologies to provide energy efficient and cost-effective future solutions for energy and environment related processes. Based on this approach the research projects which are trying to find attractive carbon materials in our days are many. The published papers, per year, in the topic of carbon membranes, especially for biogas upgrading, natural gas sweetening and hydrogen purification, are numerous with very high impact. However, only few are the books which include relevant to the topic of carbon membrane technology. This book offers the condensed and interdisciplinary knowledge on carbon membranes, and provides the opportunity to the scientists who are working in the field of carbon membrane technology for gas and liquid separations to present, share, and discuss their contributions within the membrane community.
Urban Drainage and Storage Practices focuses on the latest developments in urban stormwater design methods using drainage and storage approaches for both water quality and quantity control. It covers both the conventional approaches to flood mitigation and low-impact methods for stormwater quality enhancement. Theory, practice, and modeling methods are presented to illustrate how to build a holistic stormwater drainage and storage system using urban open space and parks through multiple land use.Each chapter provides background theory, numerical experiments, illustrations, and Excel spreadsheets that outline design and calculation procedures. All urban watersheds are modeled as a series of cascading planes to drain stormwater from upstream roofs and parking lots onto downstream grass areas and vegetal beds. The drainage system is designed as a three-layer cascading system with various low-impact units for micro events, conveyance elements for minor events, and storage facilities for macro events. This book:presents the theory and practice of designing and building a stormwater systemexplains green approaches to designing and managing urban stormwater systems.This text is ideal for senior and graduate students studying urban hydrology, hydraulic engineering, and water resource management. It will also be useful for engineers requiring a technical book with hands-on practical examples.
Understanding Interaction explores the interaction between people and technology in the broader context of the relations between the human-made and the natural environments. It is not just about digital technologies - our computers, smartphones, the Internet - but all our technologies, such as mechanical, electrical, and electronic. Our ancestors started creating mechanical tools and shaping their environments millions of years ago, developing cultures and languages, which in turn influenced our evolution. Volume 1 looks into this deep history, starting from the tool-creating period (the longest and most influential on our physical and mental capacities) to the settlement period (agriculture, domestication, villages and cities, written language), the industrial period (science, engineering, reformation, and renaissance), and finally the communication period (mass media, digital technologies, and global networks). Volume 2 looks into humans in interaction - our physiology, anatomy, neurology, psychology, how we experience and influence the world, and how we (think we) think. From this transdisciplinary understanding, design approaches and frameworks are presented to potentially guide future developments and innovations. The aim of the book is to be a guide and inspiration for designers, artists, engineers, psychologists, media producers, social scientists, etc., and, as such, be useful for both novices and more experienced practitioners. a Image Credit: Still of interactive video pattern created with a range of motion sensors in the Facets kaleidoscopic algorithm (based underwater footage of seaweed movement) by the author on 4 February 2010, for a lecture at Hyperbody at the Faculty of Architecture, TU Delft, NL.
This fully updated second edition of The Physics of Phonons remains the most comprehensive theoretical discussion devoted to the study of phonons, a major area of condensed matter physics.It contains exciting new sections on phonon-related properties of solid surfaces, atomically thin materials (such as graphene and monolayer transition metal chalcogenides), in addition to nano- structures and nanocomposites, thermoelectric nanomaterials, and topological nanomaterials, with an entirely new chapter dedicated to topological nanophononics and chiralphononics. Although primarily theoretical in approach, the author refers to experimental results wherever possible, ensuring an ideal book for both experimental and theoretical researchers.The author begins with an introduction to crystal symmetry and continues with a discussion of lattice dynamics in the harmonic approximation, including the traditional phenomenological approach and the more recent ab initio approach, detailed for the first time in this book. A discussion of anharmonicity is followed by the theory of lattice thermal conductivity, presented at a level far beyond that available in any other book. The chapter on phonon interactions is likewise more comprehensive than any similar discussion elsewhere. The sections on phonons in superlattices, impure and mixed crystals, quasicrystals, phonon spectroscopy, Kapitza resistance, and quantum evaporation also contain material appearing in book form for the first time. The book is complemented by numerous diagrams that aid understanding and is comprehensively referenced for further study. With its unprecedented wide coverage of the field, The Physics of Phonons is an indispensable guide for advanced undergraduates, postgraduates, and researchers working in condensed matter physics and materials science.FeaturesFully updated throughout, with exciting new coverage on graphene, nanostructures and nanocomposites, thermoelectric nanomaterials, and topological nanomaterials.Authored by an authority on phonons.Interdisciplinary, with broad applications through condensed matter physics, nanoscience, and materials science.--
Volume 23, entitled Molecular Bio-Sensors and the Role of Metal Ions, of the series Metal Ions in Life Sciences (MILS) represents a milestone of contemporary progress and understanding of molecular bio-sensors for metal ions. It is bringing together the latest research in academia and industry, and it also emphasizes the spectrum of evolving regulations from regulatory bodies. This vibrant research area is covered by 31 internationally recognized experts. The impact of MILS-23 is manifested by more than 1300 references and close to 200 figures, more than 100 of them in color; further information is summarized in several tables. In conclusion, Volume 23 significantly advances our understanding of Molecular Bio-Sensors, it is therefore an essential resource for scientists working in the wide range from earth sciences, material sciences, physics, pharmacology, enzymology, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic.¿ It provides an understanding of the roles that metals play in living systems.¿ It offers an insight for the demands needed in the clinic.¿ It reveals the interplay between bio-sensors and therapies.¿The Series METAL IONS IN LIFE SCIENCES increases our understanding of the relationship between the chemistry of metals and life processes. The volumes reflect the interdisciplinary nature of Biological Inorganic Chemistry and coordinate the efforts of researchers in fields like biochemistry, inorganic chemistry, coordination chemistry, molecular and structural biology, enzymology, toxicology, environmental chemistry, biophysics, pharmacy, and medicine. The volumes deal with the formation, stability, structure, and reactivity of metal-containing biological compounds of low and high molecular weight. The metabolism and transport of metal ions and their complexes as well as new models of complicated natural structures and processes are in the focus. Consequently, the volumes are an essential source for researchers in the mentioned fields as well as for teachers preparing courses, e.g., in Bioinorganic Chemistry.
Handbook of Forensic Statistics is a collection of chapters by leading authorities in forensic statistics. Written for statisticians, scientists, and legal professionals having a broad range of statistical expertise, it summarizes and compares basic methods of statistical inference (frequentist, likelihoodist, and Bayesian) for trace and other evidence that links individuals to crimes, the modern history and key controversies in the field, and the psychological and legal aspects of such scientific evidence.Specific topics include uncertainty in measurements and conclusions; statistically valid statements of weight of evidence or source conclusions; admissibility and presentation of statistical findings; and the state of the art of methods (including problems and pitfalls) for collecting, analyzing, and interpreting data in such areas as forensic biology, chemistry, and pattern and impression evidence. The particular types of evidence that are discussed include DNA, latent fingerprints, firearms and toolmarks, glass, handwriting, shoeprints, and voice exemplars.
Nine years have passed since the second edition of the Handbook of Aseptic Processing and Packaging was published. Significant changes have taken place in several aseptic processing and packaging areas. These include aseptic filling of plant-based beverages for non-refrigerated shelf-stable formats for longer shelf life and sustainable packaging along with cost of environmental benefits to leverage savings on energy and carbon footprint. In addition, insight into safe processing of particulates using two- and three-dimensional thermal processing followed by prompt cooling is provided.In the third edition, the editors have compiled contemporary topics with information synthesized from internationally recognized authorities in their fields. In addition to updated information, 12 new chapters have been added in this latest release with content onDesign of the aseptic processing system and thermal processingThermal process equipment and technology for heating and coolingFlow and residence time distribution (RTD) for homogeneous and heterogeneous fluidsThermal process and optimization of aseptic processing containing solid particulatesAseptic filling and packaging equipment for retail products and food serviceDesign of facility, infrastructure, and utilitiesCleaning and sanitization for aseptic processing and packaging operationsMicrobiology of aseptically processed and packaged productsRisk-based analyses and methodologiesEstablishment of "validated state" for aseptic processing and packaging systemsQuality and food safety management systems for aseptic and extended shelf life (ESL) manufacturingComputational and numerical models and simulations for aseptic processingAlso, there are seven new appendices on original patents, examples of typical thermal process calculations, and particulate studies-single particle and multiple-type particles, and Food and Drug Administration (FDA) filingThe three editors and 22 contributors to this volume have more than 250 years of combined experience encompassing manufacturing, innovation in processing and packaging, R&D, quality assurance, and compliance. Their insight provides a comprehensive update on this rapidly developing leading-edge technology for the food processing industry.The future of aseptic processing and packaging of foods and beverages will be driven by customer-facing convenience and taste, use of current and new premium clean label natural ingredients, use of multifactorial preservation or hurdle technology for maximizing product quality, and sustainable packaging with claims and messaging.
This book aims to present an alternative based on natural processes and an environmental approach to post-excavation site management, e.g., post-coal mining heaps. These sites are places where various mineral excavation by-products are collected. Nevertheless, some post-mineral excavation sites are oligotrophic, terrestrial, wetland, and water habitat islands, providing unique biodiversity enrichment in the landscape. These oligotrophic mineral habitats are essential in over-fertilized, eutrophic, agricultural and urban-industry surroundings. Some post-mineral excavation sites are places where the wildlife can develop and support the functional processes of novel ecosystems. Implementing the newest biogeochemical and comprehensive knowledge into urban-industry landscape management will help to establish the ecosystem's processes and environmental functioning.There are several post-industrial sites in Europe where the wildlife areas developed due to natural processes, are becoming wildlife hotspots in densely populated urban-industry areas. In this respect, many of the oligotrophic mineral terrestrial, wetland, and water habitats of anthropogenic origin should not be categorized as environmentally dangerous and undergo economic utility-focused reclamation.Facing the actual environmental constraints of the Anthropocene Epoch, the book's chapters presenting the natural basics and perquisites of the environmental ecosystem mosaics, will be interesting for a broad range of environmentalists (scientists and students), miners, economists, and sociologists.
Genomic selection (GS) is a promising tool in the field of breeding especially in the era where genomic data is becoming cheaper. The potential of this tool has not been realized due to its limited adaptation in various crops. Marker Assisted Selection (MAS) has been the method of choice for plant breeders while using the genomic information in the breeding pipeline. MAS, however, fails to capture vital minor gene effects while focusing only on the major genes, which is not ideal for breeding advancement especially for quantitative traits such as yield. The main aim of statistical methodologies coming under the umbrella of GS on using the whole genome information is to predict potential candidates for breeding advancement while optimizing the use of resources such as land, manpower, and most importantly time. Lack of proper understanding of the methods and their applications is one of the reasons why breeders shy away from this tool. The book is meant for biologists, especially breeders, and provides a comprehensive idea of the statistical methodologies used in GS, guidance on the choice of models, and design of datasets. The book also encourages the readers to adopt GS by demonstrating the current scenarios of these models in some of the important crops among oilseeds, vegetables, legumes, tuber crops, and cereals. For ease of implementation of GS, the book also provides hands-on scripts on GS data design and modeling in a popular open-source statistical program. Additionally, prospective in GS model development and thereby enhancement in crop improvement programs is discussed.
Traditional studies in mycology mainly deal with damage caused by fungi, for instance, diseases of plants, animal ailments, air-borne pathogens, decomposition of wood and production of mycotoxins in food. Applied mycology focuses on the fermentation of foods (flours, bakery products, cheese and others) and production of fermented products (wine, beer and spirit). Further value-added approaches show the significance of fungi in the production of bioactive metabolites and pharmaceuticals used in the treatment of human diseases, including cancer, and plant diseases (e.g. pest control). Due to a dependence on fossil resources, production of bio-renewable merchandise gained importance and fungi serve as potential biological agents in sustaining global economy. Recent developments in mycology revealed their significance in the fields of advanced research, in particular building materials, packaging resources, electronic devises and leather-like goods. In addition, fungi possess several qualities to degrade non-biodegradable compounds in the ecosystem and assist in sustainable waste bioremediation.This book covers the current biotechnological advances and bio-prospect potential of fungi. Fungal biopolymers possess various applications, including prebiotics, therapeutics, immunoceuticals, drug-discovery and drug-delivery. Fungal bioactive metabolites have several implications beyond antibiotics, such as volatiles, biofuels, nematicides and pigments. They also serve as prospective tools in the production of nanoparticles of medicinal, nutritional and industrial significance. In view of environmental protection, fungal activity and products aid in bioremediation via degradation of xenobiotics and solid wastes. Fungi can produce agriculturally compatible metabolites to enhance plant production. Knowledge on fungal genomics facilitates the gene manipulation towards biotechnological applications (disease diagnosis, pathogen detection, gene expression and mutualistic interactions). This book addresses the application of fungi in different areas and serves as a potential knowledge bank for graduates, post-graduates and researchers contemplating fungal applications.
The Open Access version of this book, available at http://www.taylorfrancis.com, has been made available under a Creative Commons [Attribution-Non Commercial-No Derivatives (CC-BY-NC-ND)] 4.0 license. Funded by Linneaus University.It provides guidance on the design of timber buildings for fire safety, developed within the global network Fire Safe Use of Wood (FSUW) and with reference to Eurocode 5 and other international codes. It introduces the behaviour of fires in timber buildings and describes strategies for providing safety if unwanted fires occur. It provides guidance on building design to prevent any fires from spreading while maintaining the load-bearing capacity of structural timber elements, connections and compartmentation. Also included is information on the reaction-to-fire of wood products according to different classification systems, as well as active measures of fire protection, and quality of workmanship and inspection as means of fulfilling fire safety objectives.Presents global guidance on fire safety in timber buildingsProvides a wide perspective, covering the whole field of fire safety designUses the latest scientific knowledge, based on recent analytical and experimental research resultsGives practical examples illustrating the importance of good detailing in building designFire Safe Use of Wood in Buildings is ideal for all involved in the fire safety of buildings, including architects, engineers, firefighters, educators, regulatory authorities, insurance companies and professionals in the building industry.Feedback on this design guide is welcomed. A website for comments is available at www.fsuw.com.
Plants are autotrophs and sessile, while animals are heterotrophs and motile. Sessility has imposed on plants 94% hermaphroditism, 23% selfing, 3% polyploidization and 39% clonality, in comparison to < 5% herma-phroditism, < 1% selfing and 2% clonality in motile animals. Whereas plants consist of 374,000 species but 1,664 variety/species, animals comprise 1,543,196 species and 210 variety/species. Hence, plants have undergone variety diversity, while animals have species diversity. In animals and plants, the species ratio is reduced from 4.1 animals : 1.0 plant to 1.4 for pollinating animals : 1.0 pollinated plants. In pollination, animals are benefited dietarily but plants are cross pollinated, generating new gene combinations - the raw material for evolution and speciation. For the reduced species diversity in plants, reasons are traced to 90% hermaphroditism, ~ 23% selfing and 39% clonality. Clonality decreases from 100% in 6-7 tissue typed sponges and 3 tissue typed algae drastically to 0.7% in 60 tissue typed worms but gradually to ~ 23% in 60 tissued typed angiosperms. About 12-15, 5-8 and 77-80% of all animal and plant species are distributed in marine, freshwater and terrestrial habitats, respectively. Animals have conserved the 'right' sequence of gametogenesis but plants have gone through a 'wrong' sequence prior to settling with right one albeit with double fertilization in angiosperms. Both animals and plants are 80% male heterogametics. Only 0.5% of them can afford semelparity. While 20 and 57% angiosperms are perennial trees and herbs, annual herbs make up 23% only. In all of them, 85, > 19 and < 1% are pollinated by fast flying animals, wind and water, respectively. Increasing pollen load enhances fruit- and seed-set. In contrast to animals, the life cycle of plants is direct but complicated. Unlike animals, plants have greatly contributed to weathering of rocks and the atmospheric gas composition during the geological past. From dormant spores and seeds of plants, life can be restored after thousands of years.
Organizations need to stay competitive and transition from a linear make-use-dispose supply chain model to a sustainable one. This book covers techniques and basic principles, historical developments and recent issues facing the adoption of a circular supply chain model.The Circular Supply Chain: Basic Principles and Techniques presents the key principles and techniques for the effective integration of a circular economy into supply chains. It discusses sustainability, digitization and the application of blockchain to enhance operations within the realm of Industry 4.0. Principles to assist managers in effectively adopting circularity business models for sustainability improvements are provided, along with the historical background, so the reader can have a better understanding for implementation. Case studies and reading comprehension questions are also offered to help with the effective integration of a circular economy into supply chains.This book is written to assist students, practicing engineers and business professionals that work in the industrial and manufacturing sectors, supply chain management, and with advanced technologies associated with Industry 4.0, sustainability, blockchain and digitalization integration techniques of circular supply chains.
Soft computing techniques are no longer limited to the arena of computer science. The discipline has an exponentially growing demand in other branches of science and engineering and even into health and social science. This book contains theory and applications of soft computing in engineering, health, and social and applied sciences. Different soft computing techniques such as artificial neural networks, fuzzy systems, evolutionary algorithms and hybrid systems are discussed. It also contains important chapters in machine learning and clustering. This book presents a survey of the existing knowledge and also the current state of art development through original new contributions from the researchers. This book may be used as a one-stop reference book for a broad range of readers worldwide interested in soft computing. In each chapter, the preliminaries have been presented first and then the advanced discussion takes place. Learners and researchers from a wide variety of backgrounds will find several useful tools and techniques to develop their soft computing skills. This book is meant for graduate students, faculty and researchers willing to expand their knowledge in any branch of soft computing. The readers of this book will require minimum prerequisites of undergraduate studies in computation and mathematics.
This book focuses on latent heat storage, which is one of the most efficient ways of storing thermal energy. Unlike the sensible heat storage method, the latent heat storage method provides much higher storage density with a smaller difference between storing and releasing temperatures.Thermal Energy Storage with Phase Change Materials is structured into four chapters that cover many aspects of thermal energy storage and their practical applications. Chapter 1 reviews selection, performance, and applications of phase change materials. Chapter 2 investigates mathematical analyses of phase change processes. Chapters 3 and 4 present passive and active applications for energy saving, peak load shifting, and price-based control heating using phase change materials.These chapters explore the hot topic of energy saving in an overarching way, and so they are relevant to all courses. This book is an ideal research reference for students at the postgraduate level. It also serves as a useful reference for electrical, mechanical, and chemical engineers and students throughout their work.FEATURESExplains the technical principles of thermal energy storage, including materials and applications in different classificationsProvides fundamental calculations of heat transfer with phase changeDiscusses the benefits and limitations of different types of phase change materials (PCM) in both micro- and macroencapsulationsReviews the mechanisms and applications of available thermal energy storage systemsIntroduces innovative solutions in hot and cold storage applications
As one of the most extensive and important protein post-translational modifications, glycosylation plays a vital role in regulating organisms and is associated with various physiological and pathological processes. Recently, researchers have focused on the need to characterize protein glycosylation sites, structures, and their degree of modification, to better understand their biological functions while also looking for potential biomarkers for diagnosis and treatment of disease.Mass spectrometry (MS) is one of the most powerful tools used to study biomolecules including glycoproteins and glycans. With the continuous development of glycoproteomics and glycomics based on MS analysis, more techniques have evolved and contribute to understanding the structure and function of glycoproteins and glycans. This book reviews advancements achieved in MS-based glycoproteomic analysis, including a wide range of analytical methodologies and strategies involved in selective enrichment; as well as qualitative, quantitative, and data analysis, together with their clinical applications. Significant examples are discussed to illustrate the principles, laboratory protocols, and advice for key implementation to ensure successful results.Mass Spectrometry-Based Glycoproteomics and Its Clinic Application will serve as a valuable resource to elucidate new techniques and their applications for students, postdocs, and researchers working in proteomics, glycoscience, analytical chemistry, biochemistry, and clinical medicine.Editor:Haojie Lu is a professor at Fudan University, specializing in proteomics based on mass spectrometry with particular emphasis on novel technologies for separation and identification of low-abundant proteins and post-translationally modified proteins (including glycosylation), as well as relative and absolute quantification methods for proteomics.
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