Bücher veröffentlicht von Humana Press Inc.

There are also comprehensive reviews on specific disease topics including chronic obstructive lung disease, lung cancer, atypical mycobacteria, interstitial lung disease, pulmonary hypertension, pulmonary embolism, obstructive sleep apnea, sleep disorders in older patients.

Cancer Stem Cells in Solid Tumors represents a detailed overview of cancer stem cells and their role in solid cancers. Comprised of 24 chapters, this volume provides readers with a comprehensive understanding of this important and evolving field.

and suitable animal models for non-human clinical trials.The chapters of this book are organized into six sections: Stem Cells, Biomaterials and the Extracellular Environment, Engineered Tissue, Synthetic Organs, Immune Response, and Animal Models.

Targeted Therapies highlights changes in the signaling network in response to inhibition of a signaling event. The text illustrates how a mechanistic understanding of the signaling network in cancer is important to developing targeted cancer therapies.

This volume will provide a contemporary account of advances in chemical carcinogenesis. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens.

Scientists investigating germ cells have, over the past 15 years, originated discoveries and innovations that give us valuable insights into the mechanisms that regulate not just stem cell function, but human development in its widest sense.

There are currently no reparative therapies for severe neurological injury, including brain injury, spinal cord injury and stroke. Progenitor Cell Therapy for Neurological Injury is a compilation of seminal essays that explore many unique aspects of neurological injury, focusing on the critical translational issues of cell delivery.

Part VIII probes psychosocial and cultural factors affecting judgment and decisions about translational stem cell research, and Part IX explores problems and procedures raised by an examination of the evaluation of stem cell research projects in research ethics committees.

The role of free radicals and oxidative stress in neurological disorders has only recently been recognized, leaving clinical neurologists to seek in vain for information on the subject even in major textbooks.

Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980's with its identification as an effector of phorbol esters, natural products with tumor promoting activity.

Features that characterize the aging process include the gradual accumulation of cell damage after prolonged exposure to oxidative and inflammatory events over a lifetime. Aging and Aging-Related Disorders examines the interface between normal and pathological aging, and illustrates how this border can sometimes be diffuse.

Stem Cell Therapy for Diabetes, one of the latest installments of the Stem Cell Biology and Regenerative Medicine series, reviews the three main approaches for generation of sufficient numbers of insulin-producing cells for restoration of an adequate beta-cell mass: beta-cell expansion, stem-cell differentiation, and nuclear reprogramming.

This book shows how a bioinformatics approach has been used to characterize various cancer-related processes. It provides a historical and technical perspective on the analytical techniques, methodologies, and platforms used in bioinformatics experiments.

This book reviews preparation of expression vectors, generation of high-yielding clones, scale-up, disruption of yeast cells to enable isolation of recombinant protein prior to purification and more, in the popular Methods in Molecular Biology(TM) format.

Studies on Men's Health and Fertility provides a comprehensive series of up-to-the-minute reviews addressing the role of oxidative stress in the aetiology of reproductive pathologies in the male.

This Methods in Molecular Biology(TM) volume offers detailed protocols for the preparation of plant genomic DNA, fingerprinting of plants for the detection of intra-species variations, use of DNA barcoding and methods for the bioinformatic analysis of data.

This book examines the role that oxidative and nitrosative stress plays in the physiology and pathophysiology of the retina and choroid. It serves as the ideal guide to understanding the retinal and choroidal cellular mechanisms involved in aging and disease.

This book examines developments in statistical methodology and the challenges that followed rapidly improving sequencing technologies. Includes articles encompassing theoretical works and hands-on tutorials, as well as many reviews with key biological insight.

This highly practical volume, with its step-by-step techniques, brings together recent developments in the statistical methodology of evolutionary genomics and the challenges that followed as a result of rapidly improving sequencing technologies.

This book introduces DIGE and its advantages in quantitative protein analysis, providing detailed protocols and important notes on the practical aspects of DIGE with both generic and specific applications in the various areas of Quantitative Proteomics.

This revised and updated third edition includes five new chapters and delivers a resource that will enhance clinical knowledge of the complex mechanisms, risks, and consequences of drug interactions associated with antimicrobials, infection, and inflammation.

Adverse drug reactions and interactions remain a major healthcare issue. This fully updated and revised new edition of the indispensible guide to drug interactions includes fresh research on pharmacogenomics as well as an expanded section on illicit drugs.

Additional chapters address the technology of handling biopsies, new methods for analyzing genes and gene expression, markers of clinical outcome and progress, analysis of tumor-derived proteins and antigens, validating targets, and investigating the biology of newly discovered genes.

Pancreatic Cancer: Methods and Protocols provides a broad range of protocols for molecular, cellular, pathological, and statistical analyses of s- radic and familial pancreatic cancer.

Developed for a range of tissues where the culture environment takes into account the spatial organization of the cells therein, 3D cell culture models serve to bridge the gap between in vivo studies at one extreme with that of simple cell monolayers at the other.

Embryonic stem cells (ESCs) offer an unlimited self-renewing capacity, as opposed to the limits of adult stem cells;

Prostate cancer is the most common noncutaneous prostate cancer. deprivation therapy [ADT]) has become widely drugs that target specifc pathways, including ang- accepted as the mainstay of therapy for the treat- genesis and tyrosine kinase inhibitors, endothelin ment of advanced prostate cancer.

Psychodynamic Psychotherapy Research: Evidence-Based Practice and Practice-Based Evidence continues the important work of the first book published in 2009 by Humana Press (Handbook of Evidence-Based Psychodynamic Psychotherapy: Bridging the Gap Between Science and Practice).

Targeted Therapies highlights changes in the signaling network in response to inhibition of a signaling event. The text illustrates how a mechanistic understanding of the signaling network in cancer is important to developing targeted cancer therapies.