Bücher veröffentlicht von Humana Press Inc.

Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium and nutrients across the retinal pigment epithelium.

This book presents a multidisciplinary survey of biostatics methods, each illustrated with hands-on examples. It introduces advanced methods in statistics, including how to choose and work with statistical packages.

In 2003, the word "coronavirus" spread across the globe, somewhat further than the virus that sparked the panic. In this book, expert researchers examine these devastating viruses through 23 state-of-the-art, widely applicable protocols with minute detail.

Contributed by top experts and many original developers of the models, each chapter contains a step-by-step, proven procedure and visual aids covering the most commonly used animal models of neurological injury in order to highlight the practical applications of animal models rather than the theoretical issues.

In Plant Pathology: Techniques and Protocols, expert researchers provide methods which are vital to the diagnosis of plant diseases across the globe, addressing all three categories of plant pathology techniques: traditional, serological, and nucleic acid.

Now in its second edition, Modern Hematology: Biology and Clinical Management reflects the major advances in the understanding, diagnosis, and treatment of blood disorders. In 23 chapters, all major blood diseases are covered, as well as rare diseases that are of scientific interest.

This second edition addresses the complex, multifaceted relationships between nutrition and oral health, explores proposed relationships between oral, systemic and nutritional well-being and provides insights into interprofessional, comprehensive care for individuals.

An integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product.

Applied Neurogenomics

Organism Models of Autism Spectrum Disorders

The 2nd edition of this Methods in Molecular Biology(TM) book offers methods for investigating production and analysis of transgenic plants, focused on selection and detection methods, transformation technology, targeting, silencing and directed mutation and more.

A state-of-the art collection of readily reproducible laboratory methods for assessing chemosensitivity in vitro and in vivo, and for assessing the parameters that modulate chemosensitivity in individual tumors.

This volume focuses on cytological, biochemical, and molecular biological methods to identify and examine the function of each nuclear body, with an emphasis on the analysis of long non-coding RNAs.

Although the potential applications for such tests at the site of specimen collection, now called "on-site" or "point-of-care" testing, range far beyond hospital emergency rooms and law enforcement needs, it was catalyzed by the requirements of workplace drug testing and other drugs-of-abuse testing programs.

A panel of recognized authorities comprehensively review the medical, surgical, and pathophysiologic issues relevant to lung volume reduction surgery for emphysema. The experts also detail the selection of candidates for LVRS, the clinical results and clinical trials in LVRS, and the effects of LVRS on survival rates.

Its growth in recent years can be related, in part, to increased interest in and concern with the fact that a growing number of anthropogenic agents with neurotoxic potential, including pesticides, lead, mercury, and the polytypic bypro ducts of combustion and industrial production, continue to be spewed into and accumulate in the environment.

Insightful and evidenced-based, Bladder Cancer: Current Diagnosis and Treatment provides active clinicians and clinical investigators with not only a critical survey of the rapidly expanding research in the area, but also a state-of-the-art tutorial on today's optimal assessment and treatment of bladder cancer.

During the past five to ten years, a variety of tools has been developed in the disciplines of both gene engineering, and molecular and structural biology. Some of these advances have permitted scientists not only to identify and characterize genes, but also to target these genes by disruption, thus eliminating their function in living animals, and to det- mine the biological responses to altered gene products. This has particular significance in endocrine systems, in which feedback mechanisms between the hypothalamus, pi- itary, and end organs are critical in normal physiology. Interpretation of the physiological significance, or the site of action of specific molecules in this context, has been difficult prior to transgenic technology. Major advances have occurred specifically in the areas of growth and development, and of reproduction. Coupled with analysis of naturally occurring mutations in humans, the use of transgenic animals and in vitro systems has recently allowed endocrinologists to understand the importance of specific thyroid hormone receptor isoforms in vivo, the molecular basis for generalized resistance to thyroid hormones via mutations in the nuclear receptor, and mechanisms for suppressing gene transcription. Previously designated "orphan rec- tors," such as steroidogenic factor-1, were demonstrated to have critical roles in dev- opment and reproduction. Other nuclear receptors-including those for thyroid hormone, estrogens, androgens, and progesterone-were shown to bind to coactivator and co- pressor proteins that modified their transcriptional activity, and contributed to the ce- specific effects of the hormones.

Expert physicians and clinical researchers summarize and explain all the recent advances in the biology and treatment of bone marrow-based malignancy.

Leading clinical and experimental investigators comprehensively review the chemistry, biochemistry, molecular biology, physiology, and pathophysiology of nitric oxide in the cardiovascular systems.

The field of movement disorders is relatively broad, encompassing disorders of increased movement, such as tremors, dystonia, and tics, to disorders characterized by a paucity of movement, such as Parkinson's disease.

A distinguished panel of internationally recognized neuroscientists comprehensively review the involvement of and changes in glial cells both during the normal aging process and in the major disorders of old age.

With this seventh edition, Noback's Human Nervous System: Structure and Function continues to combine clear prose with exceptional original illustrations that provide a concise lucid depiction of the human nervous system.

Our emerging understanding of the molecular and cellular events that drive cytoskeletal mediated diseases including cancer, heart disease, myopathies and skin disorders, are also helping shape targeted therapeutic approaches to treating these diseases.

Vital to academic researchers, the medical field, and especially to biotech and pharmaceutical scientists, metabolomics is a rapidly expanding field that will provide a key link between functional biology (phenotypes) and the inner workings of cells in tissues or whole organisms.

Leading academic and biomedical researchers comprehensively review the status of essential fatty acids (EFA) in nutrition, medicine, psychology, and pharmacology.

An extraordinary compendium of information on herbal medicine, Medicinal Plants of the World, Volume 2 comprehensively documents the medicinal value of twenty-four major plants species widely used around the world in medical formulations.

In its revised 2nd Edition, this Methods in Molecular Biology(TM) book provides a complete introduction to common and emerging procedures for characterizing the interactions of individual proteins. Offers materials lists, reproducible protocols, notes and more.

Interventional Bronchoscopy: A Clinical Guide provides a state-of-the art description of interventional bronchoscopy procedures, addressing the scientific basis, indications, techniques, results, complications, and cost issues.