Bücher veröffentlicht von Humana Press Inc.

Due to the rapid and steady growth of available low-cost computer power, the use of computers for discovering and designing new drugs is becoming a central topic in modern molecular biology and medicinal chemistry.

In Liver Stem Cells: Methods and Protocols, expert researchers focus on several hepatic progenitor cells, hepatic differentiation form stem cells, bile ductal cell formation from stem cells, liver stem cells and hepatocarcinogenesi, and application of liver stem cells for cell therapy.

The aim of Two Hybrid Technologies: Methods and Protocols is to provide a compendium of state-of-the art protocols for the investigation of binary PPIs with the classical yeast two-hybrid (Y2H) approach, Y2H variants and other in vivo methods for PPI mapping.

Amino Acid Analysis: Methods and Protocols presents a broad spectrum of all available methods allowing for readers to choose the method that most suits their particular laboratory set-up and analytical needs.

This Methods in Molecular Biology(TM) book is a comprehensive guide to techniques for astrocyte cell culture, and more specialized approaches for studying astrocyte functions, both in vitro and in vivo. Offers step-by-step protocols, troubleshooting tips and more.

Divided into five convenient sections, Rho GTPase: Methods and Protocols provides an historical overview of the field and an account of the phylogenetics of the Rho family, general biochemical methods, and functional assays that allow monitoring the consequences of manipulating Rho GTPases in a variety of contexts.

"Recent studies have discovered new known and characterized cytokines, allowing for advancement in miniaturization of micro-analytical methods as well as the extensive development of bio-informatics and nanotechnology.

This Methods in Molecular Biology(TM) book collects techniques applicable to the study of both the male and female germline. Includes lists of necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting.

In mTOR: Methods and Protocols expert researchers in the field detail many of the methods which are now commonly used to study mTOR. These include methods and techniques used for the study of the mTOR pathway and potential therapeutic applications of mTOR inhibitors such as, immunosuppressive and anticancer agents.

Recombinant gene expression research has brought new advances such as the birth of the 'omics' technologies. Here, expert researchers detail many RGE methods now used, including those for bacteria, fungi, plants and plant cells, and animals and animal cells.

The rapid pace of microRNA (miRNA) research continues to drive the advances of techniques for miRNA expression profiling, and innovative technologies that are more sensitive, specific, quantitative, and that are compatible with a wide range of biospecimens have been developed during the past few years.

In the last decade the life sciences have evolved at a startling rate, culminating in today's high-throughput methods in biochemistry laboratories. In this book, expert researchers focus on dynamic aspects of the transcriptome, proteome and metabolome.

Coupling features of chromatography and mass spectrometry, SELDI is a popular method of biomarker discovery. This volume reviews its current applications, emphasizing study and experimental design, data analysis and interpretation, and assay development.

Evaluating potential mutagenic activity is a critical step in assessing the safety of both new and pre-existing chemical types. In this book, expert contributors help to satisfy the demand for education in this vitally important field of research.

New pathways have been discovered and expanded our knowledge of the ways in which genes and gene products affect bone cells and thereby bone mass and bone strength.

The rapid expansion of synthetic biology is due to the design and construction of synthetic gene networks that have opened many new avenues in fundamental and applied research.

These methods and techniques include resources for microarray bioinformatics, microarray data analysis, microarray bioinformatics in systems biology, next generation sequencing data analysis, and emerging applications of microarray and next generation sequencing.

Although the cause of most malignant melanomas - over-exposure to ultraviolet light - is well known, effective treatment has remained challenging. The past several years have been marked by extraordinary developments in melanoma treatment in the arena of targeted therapeutics.

During the last 30 years it has become clearly evident that oxidative stress and free radical biology play key roles in carcinogenesis, cancer progression, cancer therapy, and normal tissue damage that limits treatment efficacy during cancer therapy.

This book offers a comprehensive presentation of histological diagnosis and differential diagnoses of Gestational Trophoblastic Disease (GTD). It provides in-depth reviews of the molecular genetic background of GTD, epidemiology and risk factors.

This Methods in Molecular Biology(TM) volume offers methods for applying the principles of nanotechnology to tissue regeneration. Covers delivery systems and biosensors, and techniques for studying interaction between cells, biomolecules and surfaces at nanoscale.

In Diabetes & C-Peptide: Scientific and Clinical Aspects, a renowned group of leading researchers and physicians offers a comprehensive overview of the role of C-Peptide in type 1 diabetes.

A concise summary of the most important medical and scientific topics concerning cardiovascular medicine in the primary care environment, this new edition of Cardiology in Family Practice has been updated with cutting-edge information and useful tips.

Display technologies are a powerful biological tool, yet the complexity of ribosome display methods has inhibited their use. This volume provides detailed and easily followed protocols with the aim of facilitating a greater uptake of these methods.

Mounting evidence stemming from more than 10 years of experimental, epidemiological and clinical studies has transformed the once generally discounted subject of endocrine disruptors into an issue of tremendous concern not only within the scientific community but among society as a whole.

Provides health professionals in areas of research and practice the importance of iron as a nutrient and its role in health and disease. This volume is the benchmark in the complex area of interrelationships between the essentiality of iron, and its functions throughout the body.

In the best case, genetic analysis in the 'biocrime' sector can exclude sources, narrow the population of possible sources and support associations with potential sources.

Molecular profiling technology has advanced dramatically, particularly in the field of cancer tissue biomarkers. This title focuses on the entire process from discovery to commercialization. It helps scientists in understanding the advancements in genomics, proteomics, imagining, and bioinformatics.

The authors provide pertinent basic, clinical, diagnostic, and management guidelines for all the conditions commonly encountered in the neurocritical care unit, including the management of autonomic disorders that require critical care, postoperative management, and endovascular treatment.

The second edition of this volume reflects the recent advances in the FCM analysis of hematopoietic disorders. The chapters have been revised to incorporate new text and figures.