Bücher veröffentlicht von Humana Press Inc.

This book presents techniques for modeling and assessing motor function in experimental animals from lower orders through vertebrate species to mammals. Volume I offers methods for assessing movement disorder and an extensive section on dopamine systems.

Here are techniques for modeling and assessing motor function in experimental animals from lower orders through vertebrates to mammals. Vol. II covers basal ganglia, neo- and allo-cortical systems, cerebellar and brain stem systems and spinal cord systems.

This book describes the basic mechanisms that allow tissue cells to attach to each other and to the extracellular matrix. Includes comprehensive data on structural, mechanistic and signaling aspects of adhesive interactions in both normal and cancer cells.

In this book, experts present a broad range of available and developing techniques for the analysis of gene expression at the DNA, RNA, and protein levels. A collection of clearly described and illustrated chapters includes tips and implementation advice.

This timely and authoritative book aims to provide a comprehensive toolkit to study gene regulatory networks from the point of data generation to processing, visualization, and modeling. The book is intended for novices and experienced researchers alike.

In Protein Microarrays: Methods and Protocols, expert researchers in the field present an up-to-date collection of robust strategies in the field of protein microarrays and summarize recent advantages in the field of printing technologies, the development of suitable surface materials, as well as detection and quantification technologies.

This book provides an overview of single-molecule approaches applied to biomolecules, including a solid introduction to the most widely used single-molecule techniques. It features readily reproducible laboratory protocols and notes on troubleshooting.

This volume will provide a contemporary account of advances in chemical carcinogenesis. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens.

Avian Influenza Virus, Second Edition aims to provide the essential methods used in working with animal influenza viruses, and to compile more advanced information that will guide the user in designing influenza studies.

This volume provides brief introductions and clear instructions for the applications of many common and useful in silico tools. It features a variety of tools with easy to follow methodologies and includes key tips and vital implementation advice.

This book presents the latest methods and technology used to characterize and discover novel mechanisms of G protein-coupled receptors (GPCRs) which, in many cases, can be used directly to design experiments for the reader's particular GPCR of interest.

This Methods in Molecular Biology(TM) volume offers detailed protocols, with theoretical background, and step-by-step instructions on implementing synchronization, as well as current techniques for the enhanced study of regulatory mechanisms in cell cycle events.

Recent years have seen significant advances in technologies that enable us to analyze transcription factors, a pivotal cell regulatory process in plants. This comprehensive survey covers the basic concepts as well as detailed protocols of tools to study TFs.

This Methods in Molecular Biology(TM) volume covers basic protocols for the study of integrin and related cell adhesion molecule functionality, and showcases the most promising methods and technologies for the development of novel therapeutics and diagnostics.

In Vitro Neurotoxicology: Methods and Protocols presents a series of cellular, biochemical, and molecular methodological protocols in the area of in vitro neurotoxicology. Features key tips and advice, there is emphasis on mammalian cell culture systems.

This book presents an up-to-date view of yeast as a model eukaryote for systems biology studies. It provides practical, easy to use methodologies and includes key tips and vital implementation advice from the experts.

In this succinct and practical guide, expert contributors cover standard and novel techniques that facilitate the study of stem cell migration. The book emphasizes in vivo technologies and includes protocols on germ, neuronal, and hematopoietic stem cells.

In this book, researchers update the classic methods and introduce new approaches that go beyond basic conjugation techniques. There is emphasis on the interplay of organic synthesis, molecular biology, surface biotechnology and biomaterials engineering.

This Methods in Molecular Biology(TM) series book outlines processes in nanoscale technology-enabled biocatalysis, including preparation of dynamic protein structures, and methodologies with potential for scale-up preparation of nano-structured biocatalysts.

Using the Methods in Molecular Biology(TM) format, this book covers key areas in food safety: detection of low level chemical residues, pesticide analysis using chromatographic techniques, and the revealing of mycotoxins and chemical contaminants in packaging.

Despite the many milestones in cystic fibrosis (CF) research, progress toward curing the disease has been slow, and it is increasingly difficult to grasp and use the already wide and still growing range of diverse methods currently employed to study CF so as to understand it in its multidisciplinary nature.

RNAi and Plant Gene Function Analysis: Methods and Protocols will provide both professionals and novices of plant biotechnology and breeding research with essential tips for designing experiments meant to explore plant gene function.

Homologous recombination is important in various aspects of DNA metabolism, including damage repair, replication, telomere maintenance, and meiosis, and yeast genetics has successfully provided a framework for the mechanism of homologous recombination.

Interest in the field of microbial toxins is ever growing and spreading across a broad spectrum of scientific disciplines. In an effort to supplement the available reference texts on toxins, Microbial Toxins: Methods and Protocols includes protocols on mold fungus toxins, with some focus on aflatoxins.

Whether the question is one of basic cell survival, or whether it is being used to correlate cell number to some other factor such as matrix synthesis, an estimate of cell viability is universally required.

This book offers detailed protocols in the growing area of neuroproteomics, with step-by-step, easy to follow instructions, practical tips and key implementation advice, along with established methods that play supporting roles in the workflow.

Despite the many milestones in cystic fibrosis (CF) research, progress towards curing the disease has been slow, and it is increasingly difficult to grasp and use the already wide and still growing range of diverse methods currently employed to study CF so as to understand it in its multidisciplinary nature.

The huge potential for gene therapy to cure a wide range of diseases has led to high expectations and a great increase in research efforts in this area, particularly in the study of delivery via viral vectors, widely considered to be more efficient than DNA transfection.

The rapid progression of genetics and molecular biology has turned chromosomal engineering from science fiction to reality, with the successful production of transgenic animals with engineered chromosomes and chromosomes developed for pharmaceutical protein production which are now ready for the medical industry.

Cytogenetic studies of malignancy have become a central tool in the clinical management of cancer patients. Now in a second, revised edition, this book presents practical cytogenetic and FISH techniques for every stage of the diagnostic process.