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Making sure that people are involved and central to their care is now recognised as a key component of developing high quality healthcare. Adopting person-centred care as "business as usual" requires fundamental changes to how services are delivered and to roles - not only those of health care professionals, but of patients too - and the relationships between patients, health care professionals and teams.Countless occasions over the last few years have reminded me again and again that there is much more to health than vital signs, laboratory tests, or medications. As physicians, we need to remove administrative obstacles and allow our patients' wish to take an active role in their own care. Navigating between an individual's need to fight a life-threatening illness and the desire to remain intellectually acute is one of medicine's greatest challenges. Bedridden as our patients may be, some reveal a zest for life. They are compelled by something much deeper than the pursuit of the perfect physical condition, which many of us erroneously equate with health. They operate out of courage and that indefatigable need to persevere to fulfil one's purpose no matter what the challenge.Truly, to grasp the deepest meaning of health, it is necessary to broaden its definition beyond the physical. Optimal health requires an integration of physical, mental, spiritual, social and environmental wellbeing.Consistent with the personalisation agenda, health and social care services give people control over, and responsibility for their own health and wellbeing working in partnership with health and social care professionals. They put people at the centre of the planning process, and recognise that they are best placed to understand their own needs and how to meet them.In recent years there has been a return to natural remedies, putting to the test the ancient curative traditions. Many have received the backing of science. Today, although there is evidence of the usefulness of natural remedies, people continue to search for confirmation, and we will share the most relevant of these findings.There is growing recognition about the linkages between working conditions, health, and productivity. At industry and institutional level, the importance of health is often played down. It is increasingly important to gain a critical understanding of the psychological, social and organisational aspects of the dynamic relationship between work and health.It is important for health policy to recognise the importance of self-care, especially where it intersects with health systems and health professionals. Given the potential to enhance health and wellbeing, self-care is an important component of people-centred care. A people-centred framing emphasises psychological, empowerment, and self-fulfilment needs, placing less emphasis on technical activities and instead looking at self-care in terms of capacities, building on a person's "health assets," both as a condition for and a product of the practice of self-care.Health needs to be recognised as an ongoing process of self-discovery, manifesting as positive influence on the world around us. It is a means to living a successful and satisfying life. Individual efforts are necessary but insufficient for optimal health. We need to create approaches and systems in economics, environment, politics, and in the delivery of medical care that elicit and sustain individual strategies.True quality of life is holistic. It is not possible to have a happy existence by only caring for one or two aspects of the human dimensions. All are part of the same fabric, and balanced health is only possible when all are cared for.

With the present emerging artificial intelligence (AI) technologies, computational "machine learning" techniques for training and generalisation from data, and cutting-edge statistical techniques, will play a significant role in analysing multidimensional datasets generated by the new technologies of systems medicine. This progressively but rapidly leads to a "new taxonomy," generating new approaches for disease diagnosis, therapy, and clinical decisions, promising more individualised treatments and improved outcomes for patients. Indeed, if this approach becomes efficient in clinical practice, it provides a real paradigm change in health care, from reactive to proactive medicine.Precision medicine will allow big data patterns to emerge and algorithms to be developed, which, in turn, will allow more predictive and precise decisions about one's health to be made. Considering the rapid scientific advances in genomics and the vast adaptation of wearable technology and other quantified self-applications, it is likely only a matter of time before this data will play a larger and more integrated role in public healthcare services.Precision medicine, sometimes called personalised medicine, is an emerging technological advancement which aims to personalise prevention and treatment according to the genetic, environmental, and lifestyle variability of individual persons or a specific group of people with commonalities, as opposed to the 'one-glove-fits-all' approach which has less consideration for the uniqueness of the individual person or specific group of people with commonalities such as similar genetic changes in a tumour. Perhaps, the clearest utility of precision medicine approaches thus far has emerged from efforts to improve disease diagnosis with the promise of better treatment. This perspective emerged as a critique of medical practices characterised as employing reductionist and oversimplified methods of disease categorisation.Treatment is not the only aim of precision medicine, but prevention is also important as genetic testing for people with a family history of a certain illness such as diabetes mellitus, could also receive tailored preventive measures before those people even get sick. As such, precision or personalised medicine is driven not only by individual health data, but also by the availability of reference medical knowledge and evidence, that is, precision or personalised medicine is linking knowledge with individual health data for decision support.The current evolution of personalised medicine is happening at a fast pace, whereby it goes beyond therapeutics selection for a patient but into the realm of drug discovery, planning and delivery of care, and engagement between consumers and companies focusing on the improvement of healthcare. Such rapid evolution of personalised medicine is largely driven by advances in diagnostics, digitalisation, data and analytics operating across a broad scope.Nonetheless, precision or personalised medicine can be considered as the cornerstone of modern medicine. With so many hospital admissions being attributed to a 'one-size-fits-all' prescribing approach and adverse drug reactions being among the leading causes of death globally, not to mention the huge economic implications this creates, a tailored approach for every patient is needed. At the centre of this should be pharmacogenomics with the goal to improve drug safety and efficacy. Furthermore, therapy for each patient should be designed according to their personal characteristics, health status, lifestyle and pharmacogenetic profile. Ultimately, the goal of precision or personalised medicine is to contribute towards preventive, predictive and participatory health systems.

"You are not here to make a living. You are here in order to enable the world to live more amply, with greater vision, with a finer spirit of hope and achievement. You are here to enrich the world, and you impoverish yourself if you forget that errand." - Woodrow WilsonFrom the core of our being, we need to develop the right attitude toward life. The simple fact that attitude "makes" some while "breaking" others is a significant enough reason for us to explore how it works and how it is cultivated. How a person defines life's events will do more than anything else to determine his or her potential for success in life. You do not have to be gifted or exceptionally bright to employ these truths in your life, but you must be willing.We have to retrain our eyes. The reason is this: whatever we are looking for is what we will see. If you are not looking for what is good, then even what good there is present will be difficult to recognise. One way to cultivate staying power is to change your definition of an event or circumstance. After all, the way in which you define your circumstances will determine, to a large degree, how you will respond to that event.Cultivate a spirit of gratefulness, regardless of your circumstances. Take the time to appreciate. Learn to enjoy the ride called life. There are going to be challenges and mountains to climb on this journey. That is a given. Once you know that mountains and trials will always be there, you will be able to expect them and no longer be surprised by them, which will free you up and enable you to enjoy the ride. You will be pleasantly surprised how a new perspective will help you to develop an attitude that attracts friends, laughter, joy and success!Realise that you can change your future and make a difference but only if you interrupt your present comfort zone. Mine your history for all experiences, not just career. You will see the hurdles you overcame and you will realise your own resilience, strength and gifts that will form your path.Look at your situation now. Are you working but bored? Are you unemployed? Are you depressed? Are you in pain? Be introspective to determine whether you are equipped to follow your dream. Do you need more knowledge, skills, or qualifications? You must have a crystal clear picture of where you want to be. If you can visualise your future, you can get there more easily. There will always be curveballs and you need contingency plans to prevail.The brain is a curious thing. The minute you write something down rather than just listen, the brain knows you are being serious. Write down your objectives, successes, and plan. You can have all the plans and strategies in the world, but if you do not act on them, they will remain a document that does not come to life. That is the magic of waking up, it is the action.Pay the price to build character. The deeper your character, the easier it will be for you to develop an attitude of excellence. In fact, if you wish to experience success and fruitfulness in life, character is a necessary foundation. Without it, you will never survive success. Character does not come cheap. It comes at a price - the price of digging your knees into the carpet, the price of studying, the price of suffering and the price of going through trials and discipline. We must be willing to pay the price.

By changing the way you think, you change the way you run your life.Very few people would turn down a chance to improve the way they think, if they knew how to go about it. When you have the ability to think more effectively, you can make better decisions and become a much more efficient thinker. You will learn new things faster and easier, achieve that potential that has been hiding inside you, and improve all aspects of your life.The only door locked is in your mind. The doors outside are unlocked and your potential is limitless. Yours is to walk through. So, you need to think out of the box. You can change your future by merely changing your attitude. When our mind talks, our attitude listens and responds. Because of this correlation, we have the power to literally "talk" ourselves into or out of success and satisfaction.That all sounds really good to everyone who hears about it, but their first question is always, "How can I improve my thinking ability so that I can take advantage of all of these benefits?" In this book, you will discover that there are many ways to train your brain to think more effectively. You can maximise your brain power and keep your brain agile as well. A more powerful mind can be yours, and you will be enlightened by the process!Our self-imposed belief barrier can affect the way we think because we are conditioned in a certain way. We build scotomas or blind spots to ideas or information that does not match our belief system. Blind spots can stop you from changing or growing. Be aware that what you see is not all there is to see.The main point to remember is once the subconscious mind accepts an idea, it begins to execute it. It is an interesting and subtle truth that the law of the subconscious mind works for good and bad ideas alike. This law, when applied in a negative way, is the cause of failure, frustration and unhappiness. However, when your habitual thinking is harmonious and constructive, you experience perfect health, success and prosperity.Research in neuroscience has shown evidence that the mind can be retrained to be more positive as the mind has the ability to determine how your brain thinks about what happens in your life. What does all this mean? This means that what we think, do or say matters. Be the best you can be and fulfil your life's purpose and potential through maximising your mind and brain power!

There is increasing recognition that efforts to improve global health cannot be achieved without stronger health systems.The myriad of opportunities and challenges that come with rapid technological innovations in the medical and health ecosystem, warrant an urgent need to apply systems engineering techniques and skills to solve issues pertaining to healthcare service quality, patient safety, and healthcare cost, as means to improve healthcare systems performance. Health systems engineering can solve healthcare problems that no one else can.Health systems engineering entails the application of engineering, science, management, and technological innovation to healthcare systems improvement. A successful systems engineering delivery process in healthcare should focus on defining stakeholder needs and required functionality early in the development cycle, documenting requirements, then proceeding with design synthesis and system validation while considering the complete problem. It focuses on understanding the interactions among people (patients, families, clinicians, and other stakeholders), processes (institutional, regulatory, professional ethics, etc.), and technology (medical devices and instrumentation) in the healthcare domain to formulate a systems approach to innovations that lead to improved patient outcomes.The proposed healthcare setting should have the environmental factors desired by patients and family members as expressed by them, suggesting a need for improvements in the healthcare environment. The patient and family must be kept at the centre of the systems approach. There are no technical barriers to enabling that capability, and the payoff in terms of patient and family experience may be substantial.Perhaps, health is too important to be left only to doctors; the healthcare consumer's well-being should be the primary consideration. The ultimate goal is to ensure that quality goals and objectives of the 21st century health system are achieved through accessible, safe, effective, patient-centred, timely, efficient, and equitable health care.There is no doubt that very few healthcare professionals or administrators are equipped to think analytically about health care delivery as a system or to appreciate the relevance of systems engineering tool. Even fewer are equipped to work to apply these tools. With the increasing global burden of disease, and the risk of pandemics such as we have already seen with the COVID-19, there is an urgent need to develop and enhance capacity for the design and application of health systems engineering, in order to build a better healthcare delivery system. A very important issue therefore is for the educators, students and practitioners to develop a sound understanding of what health systems engineering actually means. Accordingly, there is a need for multi-skilled professionals with qualifications in health systems engineering.This book aims to address that need. The book begins with an overview of a systems approach to healthcare. It then discusses health systems including health systems strengthening and the role of knowledge management and leadership, essential health packages, public-private partnerships, healthcare financing, and monitoring performance. Health systems engineering is discussed with a particular focus on engineering better health and care, and on how it can transform the medical and healthcare ecosystem. This book will appeal to professionals and students in medicine and healthcare, global health, public health, health economics, healthcare leadership and management, health systems strengthening and research, healthcare innovations, data analytics and health informatics, systems engineering, sustainable development, public policy, social sciences, and related fields.

Artificial intelligence (AI) is a simulation of the process of human intelligence through computers.AI has cemented its status as a powerful technology with the ability to propel a paradigm shift in healthcare and medicine of the 21st century and the future. The insights and values gained from AI and its subset, machine learning, are essential for predicting health outcomes and improving decision-making in healthcare and medicine.AI can offer revolutionary insights into medicine, through data from genetics, proteomics and other life sciences that advance the process of drug discovery and development. Discovering drugs is a crucial first step in the biopharmaceutical value chain. Drug discovery is a long, expensive and often unsuccessful process. The biopharmaceutical industry makes efforts to employ AI to improve drug discovery, reduce research and development costs, reduce the time and cost of early drug discovery, and support predicting potential risks/side effects in late clinical trials that can be useful in avoiding traumatic events in clinical trials.The rapid growth in life sciences and machine learning algorithms has led to enormous statistical access to the growth of AI-based start-ups focused on drug innovation in recent years. The growing need to curb drug discovery costs and reduce time involved in the drug development process, the rising adoption of cloud-based applications and services, and the impending patent expiry of blockbuster drugs are some of the key factors driving the growth of this market.However, shortage of AI workforce and ambiguous regulatory guidelines for medical software and lack of data sets in this field are some of the factors expected to restrain the growth of this market in the coming years.